Polypharmacy among Disabled Taiwanese Elderly

Background and objectiveIt is not known whether the correlates of polypharmacy among disabled elderly are similar to those for older adults in general. Furthermore, data on polypharmacy in the Taiwanese population are limited. Therefore, this study was conducted to determine the prevalence and correlates of polypharmacy among disabled Taiwanese elderly (aged ≥65 years).MethodsThis was a longitudinal observational study conducted on information obtained between July 2001 and June 2002. Study participants consisted of nationally representative samples of 11 788 disabled Taiwanese elderly from the ANLTCNT (Assessment of National Long-Term Care Need in Taiwan) study. Polypharmacy and major polypharmacy were defined as prescription of ≥5 and ≥10 medications, respectively, on the day of maximum numbers of prescriptions of the study year. Subject characteristics were derived from the ANLTCNT study survey data. Healthcare-related characteristics, including medication prescriptions, were obtained from the National Health Insurance (NHI) claims data. Multivariate logistic regression was performed for statistical analysis.ResultsOne-fifth (21.5%) of the sample were aged ≥85 years, and 58% were female. The prevalence of polypharmacy and major polypharmacy among disabled Taiwanese elderly was 81% and 38%, respectively. Nearly one-third (32.5%) of disabled Taiwanese elderly were exposed to polypharmacy for ≥181 days in 1 year. Compared with those with a low tendency for visiting multiple providers, those with intermediate tendency (odds ratio [OR] 3.61; 95% CI 3.11, 4.18) and those with high tendency (OR 10.24; 95% CI 8.56, 12.24) were more likely to be exposed to polypharmacy. Other significant correlates of polypharmacy in the multivariate logistic regression model included age <85 years, living in urban areas, higher number of chronic conditions, poorer physical functioning, preference for visiting independent clinics and not being institutionalized.ConclusionThe prevalence of polypharmacy was extremely high among disabled Taiwanese elderly. Visiting multiple healthcare providers was one of the strongest correlates. Policies that encourage the disabled elderly to establish primary care relationships and that promote geriatric care models may decrease the prevalence of polypharmacy and associated adverse outcomes in this group.

[1]  S. Fukuhara,et al.  Use of Prescribed Drugs Among Older People in Japan: Association with Not Having a Regular Physician , 1999, Journal of the American Geriatrics Society.

[2]  F. Haaijer-Ruskamp,et al.  The development of polypharmacy. A longitudinal study. , 2000, Family practice.

[3]  Morris Weinberger,et al.  Suboptimal Prescribing in Older Inpatients and Outpatients , 2001, Journal of the American Geriatrics Society.

[4]  A. W. Lenderink,et al.  Risk factors for the development of adverse drug events in hospitalized patients , 2000, Pharmacy World and Science.

[5]  C. Sherbourne,et al.  The MOS 36-Item Short-Form Health Survey (SF-36) , 1992 .

[6]  J. Sharkey,et al.  Patterns of therapeutic prescription medication category use among community‐dwelling homebound older adults , 2005, Pharmacoepidemiology and drug safety.

[7]  Sirpa Hartikainen,et al.  Use of medications and polypharmacy are increasing among the elderly. , 2002, Journal of clinical epidemiology.

[8]  P. Sweetnam,et al.  Polypharmacy among older men in South Wales , 1999, European Journal of Clinical Pharmacology.

[9]  A. Mitchell,et al.  Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. , 2002, JAMA.

[10]  M. Lawton,et al.  Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living , 1969 .

[11]  S. Katz,et al.  STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION. , 1963, JAMA.

[12]  L. Berkman,et al.  Two Shorter Forms of the CES-D Depression Symptoms Index , 1993 .

[13]  E. Pfeiffer A Short Portable Mental Status Questionnaire for the Assessment of Organic Brain Deficit in Elderly Patients † , 1975, Journal of the American Geriatrics Society.

[14]  J. Erikssen,et al.  Drug-related deaths in a department of internal medicine. , 2001, Archives of internal medicine.

[15]  M. Wallander,et al.  Prescription Drug Use, Diagnoses, and Healthcare Utilization among the Elderly , 2001, The Annals of pharmacotherapy.

[16]  G. Anderson,et al.  Distribution of prescription drug exposures in the elderly: description and implications. , 1996, Journal of clinical epidemiology.

[17]  S. Ogle,et al.  The Epidemiology of Serious Adverse Drug Reactions Among the Elderly , 1999, Drugs & aging.

[18]  J. Hallas,et al.  Polypharmacy: correlations with sex, age and drug regimen A prescription database study , 1998, European Journal of Clinical Pharmacology.

[19]  B. Y. Lin Integration in primary community care networks (PCCNs): examination of governance, clinical, marketing, financial, and information infrastructures in a national demonstration project in Taiwan , 2007, BMC Health Services Research.

[20]  S. Frazier Health outcomes and polypharmacy in elderly individuals: an integrated literature review. , 2005, Journal of gerontological nursing.

[21]  X. Cheng,et al.  Underuse of Medications for Chronic Diseases in the Oldest of Community‐Dwelling Older Frail Japanese , 2006, Journal of the American Geriatrics Society.

[22]  E. Damsgaard,et al.  The consumption of drugs by 75-year-old individuals living in their own homes , 2000, European Journal of Clinical Pharmacology.

[23]  J. Hanlon,et al.  Use of medications by persons 65 and over: data from the established populations for epidemiologic studies of the elderly. , 1992, Journal of gerontology.

[24]  H. Sørensen,et al.  Drug prescription for adult frequent attenders in Danish general practice: a population‐based study , 2004, Pharmacoepidemiology and drug safety.

[25]  M. Abrahamowicz,et al.  Do too many cooks spoil the broth? Multiple physician involvement in medical management of elderly patients and potentially inappropriate drug combinations. , 1996, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[26]  Cordula Wagner,et al.  Potentially inappropriate medication use among elderly home care patients in Europe. , 2005, JAMA.

[27]  H. Cohen,et al.  Factors predicting change in prescription and nonprescription drug use in a community-residing black and white elderly population. , 1996, Journal of clinical epidemiology.

[28]  Julia K. Nguyen,et al.  Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. , 2006, The American journal of geriatric pharmacotherapy.

[29]  D. Hosmer,et al.  Applied Logistic Regression , 1991 .

[30]  K. Manton,et al.  Changes in health, mortality, and disability and their impact on long-term care needs. , 1996, Journal of aging & social policy.

[31]  C. Lien,et al.  Polypharmacy and inappropriate medication use in Singapore nursing homes. , 2004, Annals of the Academy of Medicine, Singapore.

[32]  T. Klaukka,et al.  Multiuse of Medicines in Finland , 1993, Medical care.

[33]  S. Preskorn,et al.  Complexity of Medication Use in the Veterans Affairs Healthcare System: Part I: Outpatient Use in Relation to Age and Number of Prescribers , 2005, Journal of psychiatric practice.

[34]  Maryann M Fulton,et al.  Polypharmacy in the elderly: A literature review , 2005, Journal of the American Academy of Nurse Practitioners.