Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials

[1]  R. Reiter,et al.  Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation , 2020, Medicinal research reviews.

[2]  J. Higgins,et al.  Cochrane Handbook for Systematic Reviews of Interventions , 2010, International Coaching Psychology Review.

[3]  B. Yeğen,et al.  The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats , 2019, British Journal of Nutrition.

[4]  A. Zare Javid,et al.  The effects of melatonin supplementation in adjunct with non-surgical periodontal therapy on periodontal status, serum melatonin and inflammatory markers in type 2 diabetes mellitus patients with chronic periodontitis: a double-blind, placebo-controlled trial , 2018, Inflammopharmacology.

[5]  R. Reiter,et al.  The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double‐blinded, placebo‐controlled trial , 2018, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[6]  Seungyeon Kim,et al.  Use of melatonin as adjunctive therapy in neonatal sepsis: A systematic review and meta-analysis. , 2018, Complementary therapies in medicine.

[7]  G. Ortiz,et al.  Efficacy of Melatonin on Serum Pro-inflammatory Cytokines and Oxidative Stress Markers in Relapsing Remitting Multiple Sclerosis. , 2018, Archives of medical research.

[8]  M. Mansournia,et al.  The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment , 2018, Addiction biology.

[9]  R. Reiter,et al.  The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: a systematic review and meta-analysis of randomized controlled trials , 2018, Inflammopharmacology.

[10]  R. An,et al.  Global warming and obesity: a systematic review , 2018, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[11]  M. Bloch,et al.  Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders. , 2018, Focus.

[12]  M. Delgado-Rodríguez,et al.  Systematic review and meta-analysis. , 2017, Medicina intensiva.

[13]  T. Dinan,et al.  The microbiota-gut-brain axis in obesity. , 2017, The lancet. Gastroenterology & hepatology.

[14]  M. Kubo,et al.  The intestinal microbiota regulates body composition through NFIL3 and the circadian clock , 2017, Science.

[15]  R. Reiter,et al.  Mechanism of melatonin protection against copper‐ascorbate‐induced oxidative damage in vitro through isothermal titration calorimetry , 2017, Life sciences.

[16]  Z. Ruan,et al.  Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials , 2017, PloS one.

[17]  M. Ahmadian,et al.  The Effects of Melatonin in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial , 2017, Advanced biomedical research.

[18]  I. Amit,et al.  Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations , 2016, Cell.

[19]  Shaghayegh Haghjooy Javanmard,et al.  The effect of melatonin on endothelial dysfunction in patient undergoing coronary artery bypass grafting surgery , 2016, Advanced biomedical research.

[20]  R. Reiter,et al.  Melatonin as an antioxidant: under promises but over delivers , 2016, Journal of pineal research.

[21]  A. Doroszko,et al.  Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders , 2016, Mediators of inflammation.

[22]  J. Nicholson,et al.  Impact of the gut microbiota on inflammation, obesity, and metabolic disease , 2016, Genome Medicine.

[23]  A. Ostadrahimi,et al.  A Double-Blind, Placebo-Controlled Trial Related to the Effects of Melatonin on Oxidative Stress and Inflammatory Parameters of Obese Women , 2014, Hormone and Metabolic Research.

[24]  S. Legrand-Poels,et al.  Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. , 2014, Diabetes research and clinical practice.

[25]  M. Slomka,et al.  Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease--14 months follow up. , 2014, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[26]  M. Bloch,et al.  Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders , 2013, PloS one.

[27]  R. Reiter,et al.  A review of the molecular aspects of melatonin’s anti‐inflammatory actions: recent insights and new perspectives , 2013, Journal of pineal research.

[28]  J. Fichna,et al.  Distribution, function and physiological role of melatonin in the lower gut. , 2011, World journal of gastroenterology.

[29]  R. Reiter,et al.  Melatonin as a natural ally against oxidative stress: a physicochemical examination , 2011, Journal of pineal research.

[30]  J. Chojnacki,et al.  Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. , 2011, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[31]  Sohye Kim,et al.  Relationship between inflammation biomarkers, antioxidant vitamins, and bone mineral density in patients with metabolic syndrome , 2011, Nutrition research and practice.

[32]  L. Fuentes-Broto,et al.  Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity , 2011, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[33]  D. Cardinali,et al.  Melatonin—A pleiotropic, orchestrating regulator molecule , 2011, Progress in Neurobiology.

[34]  M. Slomka,et al.  The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis. , 2010, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[35]  D. Moher,et al.  Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement , 2009, BMJ : British Medical Journal.

[36]  U. Singh,et al.  Human C-reactive protein and the metabolic syndrome , 2009, Current opinion in lipidology.

[37]  S. Leonard,et al.  Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. , 2008, Free radical biology & medicine.

[38]  T. Stone,et al.  Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. , 2007, British journal of clinical pharmacology.

[39]  K. Wellen,et al.  Inflammation, stress, and diabetes. , 2005, The Journal of clinical investigation.

[40]  A. Greenberg,et al.  Adipocytokines and insulin resistance. , 2004, The Journal of clinical endocrinology and metabolism.

[41]  Mark B Pepys,et al.  C-reactive protein: a critical update. , 2003, The Journal of clinical investigation.

[42]  S. Cuzzocrea,et al.  Pharmacological actions of melatonin in acute and chronic inflammation. , 2002, Current topics in medicinal chemistry.

[43]  S. Tufik,et al.  Randomized, double‐blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment , 2000, Journal of pineal research.

[44]  E. Mazzon,et al.  Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion , 2000 .

[45]  Josep M. Guerrero,et al.  Serum cholesterol and lipid peroxidation are decreased by melatonin in diet‐induced hypercholesterolemic rats , 2000, Journal of pineal research.

[46]  R. Reiter,et al.  Melatonin and Its Relation to the Immune System and Inflammation , 2000, Annals of the New York Academy of Sciences.

[47]  G. Smith,et al.  Bias in meta-analysis detected by a simple, graphical test , 1997, BMJ.

[48]  S. Barni,et al.  Is there a role for melatonin in the treatment of neoplastic cachexia? , 1996, European journal of cancer.

[49]  P. Marchiafava,et al.  Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation. , 1996, Cardiovascular research.

[50]  M. Roselli,et al.  Modulation of cytokine production from TH2-lymphocytes and monocytes by the pineal neurohormone melatonin. , 1996, Oncology reports.

[51]  A R Jadad,et al.  Assessing the quality of reports of randomized clinical trials: is blinding necessary? , 1996, Controlled clinical trials.

[52]  C. Begg,et al.  Operating characteristics of a rank correlation test for publication bias. , 1994, Biometrics.

[53]  J. Lloyd The Importance of Vitamin E in Human Nutrition , 1990, Acta paediatrica Scandinavica.

[54]  R. Reiter,et al.  Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial. , 2019, Clinical nutrition.

[55]  R. Reiter,et al.  Melatonin in relation to the antioxidative defense and immune systems: possible implications for cell and organ transplantation , 1999, Journal of Molecular Medicine.