Just how safe is assisted reproductive technology for treating male factor infertility

Assisted reproductive technology (ART)has been responsible for the birth ofover 3 million babies since the deliveryof Louise Brown in the UK 28 yearsago. Currently, one in 80–100 childrenborn in the USA, one in 50 born inSweden, one in 40 born in Australia andone in 24 born in Denmark are theproduct of this form of treatment. In2003, more than 100,000

[1]  T. K. Jensen,et al.  Declining trends in conception rates in recent birth cohorts of native Danish women: a possible role of deteriorating male reproductive health , 2008, International journal of andrology.

[2]  R. Aitken,et al.  Seeds of concern , 2004, Nature.

[3]  C. Ong,et al.  The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma. , 2003, Mutation research.

[4]  B. V. Voorhis In vitro fertilization. , 2007, BMJ.

[5]  Anders Nyboe Andersen,et al.  Register data on Assisted Reproductive Technology (ART) in Europe including a detailed description of ART in Denmark. , 2006, International journal of andrology.

[6]  He-feng Huang,et al.  Assisted reproductive technology may increase clinical mutation detection in male offspring. , 2008, Fertility and sterility.

[7]  Diana Anderson,et al.  The effects of male age on sperm DNA damage in healthy non-smokers. , 2007, Human reproduction.

[8]  A. Sharov,et al.  Age-associated alteration of gene expression patterns in mouse oocytes. , 2004, Human molecular genetics.

[9]  Narendra Singh,et al.  Effects of age on DNA double-strand breaks and apoptosis in human sperm. , 2003, Fertility and sterility.

[10]  Michael K. Skinner,et al.  Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility , 2005, Science.

[11]  P. Laird,et al.  Widespread Epigenetic Abnormalities Suggest a Broad DNA Methylation Erasure Defect in Abnormal Human Sperm , 2007, PloS one.

[12]  R. Aitken,et al.  Oxidative stress, DNA damage and the Y chromosome. , 2001, Reproduction.

[13]  A. Lenzi,et al.  Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage. , 2004, Human reproduction.

[14]  R John Aitken,et al.  Origins and consequences of DNA damage in male germ cells. , 2007, Reproductive biomedicine online.

[15]  J. Shaman,et al.  Sperm DNA fragmentation: awakening the sleeping genome. , 2007, Biochemical Society transactions.

[16]  D. Carrell Paternal genetic and epigenetic influences on IVF outcome , 2008 .

[17]  L. Rienzi,et al.  Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. , 2005, Journal of andrology.

[18]  H. Baker,et al.  Andrology: Seminal leukocytes: passengers, terrorists or good Samaritans? , 1995 .

[19]  George R. Douglas,et al.  Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location , 2008, Proceedings of the National Academy of Sciences.

[20]  R. Jansen,et al.  First recorded pregnancy and normal birth after ICSI using electrophoretically isolated spermatozoa. , 2007, Human reproduction.

[21]  A. Agarwal,et al.  Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility. , 2003, Fertility and sterility.

[22]  P. Saunders,et al.  Impact of a mild scrotal heat stress on DNA integrity in murine spermatozoa. , 2005, Reproduction.

[23]  S. Perreault,et al.  Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality. , 2005, Human reproduction.

[24]  R. Aitken,et al.  DNA integrity in human spermatozoa: relationships with semen quality. , 2000, Journal of andrology.

[25]  R. Sram,et al.  GSTM1 genotype influences the susceptibility of men to sperm DNA damage associated with exposure to air pollution. , 2007, Mutation research.

[26]  A. Raziel,et al.  A randomized clinical trial comparing recombinant hyaluronan/recombinant albumin versus human tubal fluid for cleavage stage embryo transfer in patients with multiple IVF-embryo transfer failure. , 2007, Human reproduction.

[27]  J. Crow The origins, patterns and implications of human spontaneous mutation , 2000, Nature Reviews Genetics.

[28]  Diana Anderson,et al.  Oestrogenic compounds and oxidative stress (in human sperm and lymphocytes in the Comet assay). , 2003, Mutation research.

[29]  Muralidhara,et al.  Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences. , 2007, Reproductive toxicology.

[30]  P. Patrizio,et al.  Molecular methods for selection of the ideal oocyte. , 2007, Reproductive biomedicine online.

[31]  Niels Jørgensen,et al.  East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. , 2002, Human reproduction.

[32]  L. Hagmar,et al.  Exposure to PCBs and p,p′-DDE and Human Sperm Chromatin Integrity , 2004, Environmental health perspectives.

[33]  Elizabeth Milne,et al.  Assisted reproductive technologies and the risk of birth defects--a systematic review. , 2005, Human reproduction.

[34]  J. Meeker,et al.  Urinary levels of insecticide metabolites and DNA damage in human sperm. , 2004, Human reproduction.

[35]  A. Atkinson,et al.  Insulin dependant diabetes mellitus: implications for male reproductive function. , 2007, Human reproduction.

[36]  A. Gutiérrez-Adán,et al.  Long-Term Effects of Mouse Intracytoplasmic Sperm Injection with DNA-Fragmented Sperm on Health and Behavior of Adult Offspring1 , 2008, Biology of reproduction.

[37]  D. Kretser,et al.  Male infertility: the case for continued research , 2001, The Medical journal of Australia.