Role of Glutamatergic System and its Level of Glutamate in Rat Migraine Model

Glutamate is a major mediator of excitatory signals in the nervous system and is involved in many physiologic and pathologic processes. The understanding of glutamatergic transmission in the nervous system has been greatly expanded and the family of ionotropic and metatropic glutamate receptors. The glutamate receptors are localized at nerve terminals postsynaptic sites and glial cells and thus, they can influence and modulate the action of glutamate at different levels in the synapse. Moreover, there is substantial evidence of glial participation in glutamate nociceptive processes and neuropathic pain. Present study explains the glutamate transporters are responsible for the level of glutamate in the synaptic cleft is principally dependent on neuronal glutamate transporters in rat model.