children and adolescents

article i nfo Objective:The validity of currentultra-high risk(UHR) criteriaisunder-examined inhelp-seeking minors, partic- ularly, inchildren below theage of 12years.Thus, thepresent study investigatedpredictors of one-year outcome in children and adolescents (CAD) with UHR status. Method: Thirty-five children and adolescents (age 9-17 years) meeting UHR criteria according to the Structured Interviewfor Psychosis-Risk Syndromeswere followed-upfor 12 months.Regressionanalyseswere employedto detect baseline predictors of conversion to psychosis and of outcome of non-converters (remission and persis- tence of UHR versus conversion). Results: At one-year follow-up, 20% of patients had developed schizophrenia, 25.7% had remitted from their UHR status that, consequently, had persisted in 54.3%. No patient had fully remitted from mental disorders, even if UHR status was not maintained. Conversion was best predicted by any transient psychotic symptom and a disor- ganized communication score. No prediction model for outcome beyond conversion was identified. Conclusions: Our findings provide the first evidence for the predictive utility of UHR criteria in CAD in terms of brief intermittent psychotic symptoms (BIPS) when accompanied by signs of cognitive impairment, i.e. disorga- nized communication. However, because attenuated psychotic symptoms (APS) related to thought content and perceptionwereindicativeofnon-conversionat1-yearfollow-up,theiruseinearlydetectionofpsychosisinCAD needs furtherstudy. Overall, the need for more in-depth studies into developmental peculiarities in the early de- tection and treatment of psychoses with an onset of illness in childhood and early adolescence was further highlighted.

[1]  F. Schultze-Lutter,et al.  Age matters in the prevalence and clinical significance of ultra‐high‐risk for psychosis symptoms and criteria in the general population: Findings from the BEAR and BEARS‐kid studies , 2015, World psychiatry : official journal of the World Psychiatric Association.

[2]  S. Wood,et al.  Outcomes of nontransitioned cases in a sample at ultra-high risk for psychosis. , 2015, The American journal of psychiatry.

[3]  M. Nordentoft,et al.  EPA guidance on the early intervention in clinical high risk states of psychoses , 2015, European Psychiatry.

[4]  P. Girardi,et al.  Self-reported attenuated psychotic-like experiences in help-seeking adolescents and their association with age, functioning and psychopathology , 2014, Schizophrenia Research.

[5]  D. Malaspina,et al.  Symptom trajectories and psychosis onset in a clinical high-risk cohort: The relevance of subthreshold thought disorder , 2014, Schizophrenia Research.

[6]  Tyrone D. Cannon,et al.  Current status specifiers for patients at clinical high risk for psychosis , 2014, Schizophrenia Research.

[7]  Tyrone D. Cannon,et al.  Predicting psychosis in a general adolescent psychiatric sample , 2014, Schizophrenia Research.

[8]  Kazunori Matsumoto,et al.  A naturalistic longitudinal study of at-risk mental state with a 2.4year follow-up at a specialized clinic setting in Japan , 2014, Schizophrenia Research.

[9]  Tae Young Lee,et al.  Symptomatic and functional remission of subjects at clinical high risk for psychosis: A 2-year naturalistic observational study , 2014, Schizophrenia Research.

[10]  R. Kahn,et al.  Adolescents at ultra-high risk for psychosis: Long-term outcome of individuals who recover from their at-risk state , 2014, European Neuropsychopharmacology.

[11]  H. van Engeland,et al.  Neurocognitive and Clinical Predictors of Long-Term Outcome in Adolescents at Ultra-High Risk for Psychosis: A 6-Year Follow-Up , 2014, PloS one.

[12]  P. Tiffin,et al.  The ‘At-Risk Mental State’ for Psychosis in Adolescents: Clinical Presentation, Transition and Remission , 2014, Child psychiatry and human development.

[13]  P. Girardi,et al.  Prevalence of Psychotic-like Experiences in Young Adults With Social Anxiety Disorder and Correlation With Affective Dysregulation , 2013, The Journal of nervous and mental disease.

[14]  Barbara A Cornblatt,et al.  Prediction of functional outcome in individuals at clinical high risk for psychosis. , 2013, JAMA psychiatry.

[15]  P. Tiffin,et al.  Practitioner review: schizophrenia spectrum disorders and the at-risk mental state for psychosis in children and adolescents--evidence-based management approaches. , 2013, Journal of child psychology and psychiatry, and allied disciplines.

[16]  S. Borgwardt,et al.  Moving beyond transition outcomes: Meta-analysis of remission rates in individuals at high clinical risk for psychosis , 2013, Psychiatry Research.

[17]  P. Cuijpers,et al.  Preventing a first episode of psychosis: Meta-analysis of randomized controlled prevention trials of 12month and longer-term follow-ups , 2013, Schizophrenia Research.

[18]  Janet B W Williams.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[19]  F. Schultze-Lutter,et al.  The Schizophrenia Proneness Instrument, Child and Youth version (SPI-CY): Practicability and discriminative validity , 2013, Schizophrenia Research.

[20]  C. Correll,et al.  Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a rational, evidence-informed approach , 2013, Current opinion in psychiatry.

[21]  S. Wood,et al.  Transition to first episode psychosis in ultra high risk populations: Does baseline functioning hold the key? , 2013, Schizophrenia Research.

[22]  F. Schultze-Lutter,et al.  The Significance of At-Risk Symptoms for Psychosis in Children and Adolescents , 2013, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[23]  P. Girardi,et al.  Psychotic experience subtypes, poor mental health status and help‐seeking behaviour in a community sample of young adults , 2012, Early intervention in psychiatry.

[24]  F. Schultze-Lutter,et al.  Early detection and intervention of psychosis in children and adolescents: urgent need for studies , 2012, European Child & Adolescent Psychiatry.

[25]  J. Klosterkötter,et al.  Basic symptoms and the prediction of first-episode psychosis. , 2012, Current pharmaceutical design.

[26]  M. Cannon,et al.  Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies , 2012, Psychological Medicine.

[27]  J. Jenner,et al.  Course of auditory vocal hallucinations in childhood: 5-year follow-up study. , 2011, The British journal of psychiatry : the journal of mental science.

[28]  Tyrone D. Cannon,et al.  At clinical high risk for psychosis: outcome for nonconverters. , 2011, The American journal of psychiatry.

[29]  Tyrone D. Cannon,et al.  Thought disorder and communication deviance as predictors of outcome in youth at clinical high risk for psychosis. , 2011, Journal of the American Academy of Child and Adolescent Psychiatry.

[30]  J. Rapoport,et al.  Childhood-Onset Schizophrenia: The Challenge of Diagnosis , 2011, Current psychiatry reports.

[31]  C. Mathers,et al.  Global burden of disease in young people aged 10–24 years: a systematic analysis , 2011, The Lancet.

[32]  H. Engeland,et al.  Transition and remission in adolescents at ultra-high risk for psychosis , 2011, Schizophrenia Research.

[33]  D. Nieman,et al.  Three‐year course of clinical symptomatology in young people at ultra high risk for transition to psychosis , 2011, Acta psychiatrica Scandinavica.

[34]  P. Girardi,et al.  Psychotic-like experiences and correlation with distress and depressive symptoms in a community sample of adolescents and young adults , 2010, Schizophrenia Research.

[35]  A. Mackinnon,et al.  Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. , 2010, Archives of general psychiatry.

[36]  E. Fonseca-Pedrero,et al.  Symptomatic and functional outcome in youth at ultra-high risk for psychosis: A longitudinal study , 2009, Schizophrenia Research.

[37]  M. Lambert,et al.  Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort. , 2008, Journal of psychiatric research.

[38]  M. Lambert,et al.  Pre-treatment, baseline, and outcome differences between early-onset and adult-onset psychosis in an epidemiological cohort of 636 first-episode patients , 2007, Schizophrenia Research.

[39]  A. Yung,et al.  Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk? , 2007, Schizophrenia bulletin.

[40]  C. Correll,et al.  Can antidepressants be used to treat the schizophrenia prodrome? Results of a prospective, naturalistic treatment study of adolescents. , 2007, The Journal of clinical psychiatry.

[41]  Charles E McCulloch,et al.  Relaxing the rule of ten events per variable in logistic and Cox regression. , 2007, American journal of epidemiology.

[42]  J. Rabinowitz,et al.  A population based elaboration of the role of age of onset on the course of schizophrenia , 2006, Schizophrenia Research.

[43]  A. Yung,et al.  Psychotic-like experiences in nonpsychotic help-seekers: associations with distress, depression, and disability. , 2006, Schizophrenia bulletin.

[44]  K. Cadenhead,et al.  Risk and protection in prodromal schizophrenia: ethical implications for clinical practice and future research. , 2005, Schizophrenia bulletin.

[45]  Peter B. Jones,et al.  Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. , 2005, Archives of general psychiatry.

[46]  J. McClellan,et al.  Phenomenology and diagnostic stability of youths with atypical psychotic symptoms. , 2005, Journal of child and adolescent psychopharmacology.

[47]  Tyrone D. Cannon,et al.  The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV. , 2005, Journal of child and adolescent psychopharmacology.

[48]  T. McGlashan.  Psychosis treatment prior to psychosis onset: ethical issues , 2001, Schizophrenia Research.

[49]  A. Caspi,et al.  Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. , 2000, Archives of general psychiatry.

[50]  G. Patton,et al.  Prediction of psychosis , 1998, British Journal of Psychiatry.

[51]  N. Ryan,et al.  Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[52]  James Robert Brašić,et al.  A children's global assessment scale (CGAS). , 1983, Archives of general psychiatry.

[53]  Frauke Schultze-Lutter,et al.  Subjective symptoms of schizophrenia in research and the clinic: the basic symptom concept. , 2009, Schizophrenia bulletin.