Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs

[1]  P. Storici,et al.  Fourier transform infrared microspectroscopy reveals biochemical changes associated with glioma stem cell differentiation. , 2015, Biophysical chemistry.

[2]  G. Fròsina.  Limited advances in therapy of glioblastoma trigger re-consideration of research policy. , 2015, Critical reviews in oncology/hematology.

[3]  K. Gruden,et al.  Heterogeneous glioblastoma cell cross-talk promotes phenotype alterations and enhanced drug resistance , 2015, Oncotarget.

[4]  Monica Stanciu,et al.  Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. , 2015, Cancer research.

[5]  Marissa Friedman,et al.  Glioblastoma: Molecular Pathways, Stem Cells and Therapeutic Targets , 2015, Cancers.

[6]  Su-Jae Lee,et al.  Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients , 2014, Stem cells international.

[7]  M. E. Ruaro,et al.  Glioma‐Associated Stem Cells: A Novel Class of Tumor‐Supporting Cells Able to Predict Prognosis of Human Low‐Grade Gliomas , 2014, Stem cells.

[8]  M. Rietbergen,et al.  Cancer stem cell enrichment marker CD98: a prognostic factor for survival in patients with human papillomavirus-positive oropharyngeal cancer. , 2014, European journal of cancer.

[9]  Yanming Zhang,et al.  The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1 , 2014, Genes, chromosomes & cancer.

[10]  A. Burdova,et al.  Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2β expression to TMPRSS2-ERG fusion status in prostate cancer. , 2014, Neoplasma.

[11]  Dawang Zhou,et al.  TOP2β is essential for ovarian follicles that are hypersensitive to chemotherapeutic drugs. , 2013, Molecular endocrinology.

[12]  Leroy F. Liu,et al.  Topoisomerase IIβ Deficiency Enhances Camptothecin-induced Apoptosis* , 2013, The Journal of Biological Chemistry.

[13]  K. Gupta,et al.  Topoisomerase IIβ regulates base excision repair capacity of neurons , 2012, Mechanisms of Ageing and Development.

[14]  Raquel Herrador,et al.  Topoisomerase I poisoning results in PARP-mediated replication fork reversal , 2012, Nature Structural &Molecular Biology.

[15]  I. Weissman,et al.  Frequency of cells expressing CD44, a Head and Neck cancer stem cell marker: Correlation with tumor aggressiveness , 2012, Head & neck.

[16]  B. Campos,et al.  CD133/prominin1 is prognostic for GBM patient’s survival, but inversely correlated with cysteine cathepsins’ expression in glioblastoma derived spheroids , 2011, Radiology and oncology.

[17]  P. Zhao,et al.  Clinicopathological significance and prognostic value of CD133 expression in triple‐negative breast carcinoma , 2011, Cancer science.

[18]  R. Mandraju,et al.  Cultured cerebellar granule neurons as an in vitro aging model: topoisomerase IIβ as an additional biomarker in DNA repair and aging. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.

[19]  B. Campos,et al.  The Utility and Limitations of Neurosphere Assay, CD133 Immunophenotyping and Side Population Assay in Glioma Stem Cell Research , 2010, Brain pathology.

[20]  P. Lichter,et al.  Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells , 2010, Clinical Cancer Research.

[21]  W. Miller,et al.  Targeting PKCδ-mediated topoisomerase IIβ overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line , 2010, Leukemia.

[22]  K. Tsutsui,et al.  Topoisomerase IIβ Activates a Subset of Neuronal Genes that Are Repressed in AT-Rich Genomic Environment , 2008, PloS one.

[23]  Thomas Helleday,et al.  DNA repair pathways as targets for cancer therapy , 2008, Nature Reviews Cancer.

[24]  P. Kannapiran,et al.  Distinct roles of Topoisomerase II isoforms: DNA damage accelerating α, double strand break repair promoting β , 2008 .

[25]  P. Lichter,et al.  Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients , 2008, Clinical Cancer Research.

[26]  P. Kannapiran,et al.  Distinct roles of Topoisomerase II isoforms: DNA damage accelerating alpha, double strand break repair promoting beta. , 2008, Archives of biochemistry and biophysics.

[27]  S. Dermime,et al.  Cancer stem cell immunotherapy: the right bullet for the right target. , 2008, Hematology/oncology and stem cell therapy.

[28]  R. Bjerkvig,et al.  Cancer initiation and progression: involvement of stem cells and the microenvironment. , 2007, Biochimica et biophysica acta.

[29]  G. Kouraklis,et al.  Replication protein A is an independent prognostic indicator with potential therapeutic implications in colon cancer , 2007, Modern Pathology.

[30]  Mark W. Dewhirst,et al.  Glioma stem cells promote radioresistance by preferential activation of the DNA damage response , 2006, Nature.

[31]  Chao-Po Lin,et al.  Role of Topoisomerase IIβ in the Expression of Developmentally RegulatedGenes , 2006, Molecular and Cellular Biology.

[32]  L. Ricci-Vitiani,et al.  Chemotherapy resistance of glioblastoma stem cells , 2006, Cell Death and Differentiation.

[33]  D. Boulware,et al.  Topoisomerase II beta levels are a determinant of melphalan-induced DNA crosslinks and sensitivity to cell death. , 2006, Biochemical pharmacology.

[34]  C. Glass,et al.  A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription , 2006, Science.

[35]  J. Schlegel,et al.  Mismatch repair protein hMSH2 in primary drug resistance in in vitro human malignant gliomas. , 2004, Journal of neurosurgery.

[36]  Ugo Orfanelli,et al.  Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma , 2004, Cancer Research.

[37]  C. Sarkar,et al.  Increased hMSH2 Protein Expression in Glioblastoma Multiforme , 2004, Journal of Neuro-Oncology.

[38]  Cynthia Hawkins,et al.  Identification of a cancer stem cell in human brain tumors. , 2003, Cancer research.

[39]  A. Tokunaga,et al.  Involvement of DNA Topoisomerase IIβ in Neuronal Differentiation* , 2001, The Journal of Biological Chemistry.

[40]  M. Sehested,et al.  Essential Mitotic Functions of DNA Topoisomerase IIα Are Not Adopted by Topoisomerase IIβ in Human H69 Cells* , 1998, The Journal of Biological Chemistry.

[41]  C. Austin,et al.  Eukaryotic DNA topoisomerase II beta. , 1998, BioEssays : news and reviews in molecular, cellular and developmental biology.

[42]  S. Perkins,et al.  Differential immunohistochemical staining for DNA topoisomerase II alpha and beta in human tissues and for DNA topoisomerase II beta in non-Hodgkin's lymphomas. , 1997, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[43]  T. Tsuruo,et al.  Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines. , 1990, Cancer research.