The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms

Most mechanisms that are considered for ion channels (as for any other sort of chemical reaction) involve reversible transitions among the various possible discrete chemical states in which the system can exist. Other sorts of mechanisms may, of course, exist; for example, there may be an irreversible reaction step, a problem that is considered in Section 7. Our primary aim is to gain insight about the nature of the reaction mechanism from experimental observations. In this process, we may also obtain estimates of numerical values for the rate constants in the mechanism.

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