Energy metabolism in the liver.
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[1] P. Scherer,et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. , 2013, Cell metabolism.
[2] S. Bornstein,et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. , 2013, Cell metabolism.
[3] G. Hotamisligil,et al. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. , 2013, Cell metabolism.
[4] S. Woods,et al. Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions , 2013, Diabetes.
[5] A. Moschetta,et al. Hepatic‐specific activation of peroxisome proliferator‐activated receptor γ coactivator‐1β protects against steatohepatitis , 2013, Hepatology.
[6] F. Schütz,et al. Hepatic glucose sensing is required to preserve β cell glucose competence. , 2013, The Journal of clinical investigation.
[7] B. Staels,et al. Farnesoid X Receptor Inhibits the Transcriptional Activity of Carbohydrate Response Element Binding Protein in Human Hepatocytes , 2013, Molecular and Cellular Biology.
[8] G. Ning,et al. Yin Yang 1 Promotes Hepatic Gluconeogenesis Through Upregulation of Glucocorticoid Receptor , 2013, Diabetes.
[9] S. Young,et al. Biochemistry and pathophysiology of intravascular and intracellular lipolysis. , 2013, Genes & development.
[10] Kristopher J. Stanya,et al. Direct control of hepatic glucose production by interleukin-13 in mice. , 2013, The Journal of clinical investigation.
[11] A. Pfeiffer,et al. Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis? , 2013, Diabetologia.
[12] R. Matsumori,et al. Elovl6 promotes nonalcoholic steatohepatitis , 2012, Hepatology.
[13] G. Calamita,et al. Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes. , 2012, American journal of physiology. Gastrointestinal and liver physiology.
[14] G. Sumara,et al. Gut-derived serotonin is a multifunctional determinant to fasting adaptation. , 2012, Cell metabolism.
[15] L. Glimcher,et al. Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. , 2012, Cell metabolism.
[16] H. R. Payne,et al. Loss of intracellular lipid binding proteins differentially impacts saturated fatty acid uptake and nuclear targeting in mouse hepatocytes. , 2012, American journal of physiology. Gastrointestinal and liver physiology.
[17] In-kyu Lee,et al. Transcriptional Regulation of Pyruvate Dehydrogenase Kinase , 2012, Diabetes & metabolism journal.
[18] R. Moriggl,et al. Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development , 2012, Molecular and Cellular Endocrinology.
[19] In-kyu Lee,et al. Orphan Nuclear Receptor Small Heterodimer Partner Negatively Regulates Growth Hormone-mediated Induction of Hepatic Gluconeogenesis through Inhibition of Signal Transducer and Activator of Transcription 5 (STAT5) Transactivation* , 2012, The Journal of Biological Chemistry.
[20] J. Seong,et al. Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis , 2012, Proceedings of the National Academy of Sciences.
[21] J. Kirwan,et al. Role of ceramides in nonalcoholic fatty liver disease , 2012, Trends in Endocrinology & Metabolism.
[22] S. Mukhopadhyay,et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance , 2012, Nature Medicine.
[23] J. Auwerx,et al. LRH-1-dependent glucose sensing determines intermediary metabolism in liver. , 2012, The Journal of clinical investigation.
[24] K. Siminovitch,et al. Hepatocyte-Specific Ptpn6 Deletion Protects From Obesity-Linked Hepatic Insulin Resistance , 2012, Diabetes.
[25] H. Guillou,et al. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. , 2012, The Journal of clinical investigation.
[26] L. Rui,et al. NF-κB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action , 2012, Nature Medicine.
[27] J. Yates,et al. Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. , 2012, Cell metabolism.
[28] M. Hall,et al. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. , 2012, Cell metabolism.
[29] G. Shulman,et al. Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance. , 2012, Cell metabolism.
[30] Jiandie D. Lin,et al. Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1 , 2012, Diabetes.
[31] K. Murao,et al. Liver X Receptor α Is Involved in the Transcriptional Regulation of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Gene , 2012, Diabetes.
[32] Logan J Everett,et al. Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. , 2012, Genes & development.
[33] Z. Al-Oanzi,et al. Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes. , 2012, The Biochemical journal.
[34] Tomoshige Kino,et al. Liver X Receptors Regulate the Transcriptional Activity of the Glucocorticoid Receptor: Implications for the Carbohydrate Metabolism , 2012, PloS one.
[35] P. Tontonoz,et al. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR , 2012, Nature Reviews Molecular Cell Biology.
[36] Hongyu Zhao,et al. Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents , 2012, Hepatology.
[37] R. Coppari,et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. , 2012, The Journal of clinical investigation.
[38] G. Mitchell,et al. Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase. , 2012, Endocrinology.
[39] L. Rui,et al. Hepatic TRAF2 Regulates Glucose Metabolism Through Enhancing Glucagon Responses , 2012, Diabetes.
[40] V. Koteliansky,et al. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. , 2012, Cell metabolism.
[41] C. Kahn,et al. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1 , 2012, Nature Medicine.
[42] Jiansheng Huang,et al. Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[43] R. DePinho,et al. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. , 2012, Endocrinology.
[44] L. Cebotaru,et al. C1q/TNF-related Protein-12 (CTRP12), a Novel Adipokine That Improves Insulin Sensitivity and Glycemic Control in Mouse Models of Obesity and Diabetes* , 2012, The Journal of Biological Chemistry.
[45] Tim C. Roloff,et al. Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis , 2012, Diabetes.
[46] Richard A. Flavell,et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity , 2012, Nature.
[47] Y. Xiong,et al. Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. , 2012, Cell metabolism.
[48] A. Cherrington,et al. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. , 2012, The Journal of clinical investigation.
[49] E. Oetjen. Hepatic Glucagon Action Is Essential for Exercise-Induced Reversal of Mouse Fatty Liver , 2012 .
[50] J. Girard,et al. Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver. , 2012, Journal of hepatology.
[51] Robert A. Harris,et al. Metformin Inhibits Growth Hormone – Mediated Hepatic Pyruvate Dehydrogenase Kinase 4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner , 2012 .
[52] J. Bryan,et al. Hypothalamic Leucine Metabolism Regulates Liver Glucose Production , 2011, Diabetes.
[53] S. Burgess,et al. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. , 2011, Cell metabolism.
[54] F. Alemi,et al. Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. , 2011, Cell metabolism.
[55] T. Shioda,et al. A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans , 2011, Cell.
[56] R. Evans,et al. Cryptochromes mediate rhythmic repression of the glucocorticoid receptor , 2011, Nature.
[57] C. Palmeira,et al. Hepatic FXR: key regulator of whole-body energy metabolism , 2011, Trends in Endocrinology & Metabolism.
[58] C. Deng,et al. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. , 2011, The Journal of clinical investigation.
[59] S. Ringquist,et al. FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver , 2011, Diabetes.
[60] K. Kaestner,et al. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. , 2011, Cell metabolism.
[61] R. Zarnegar,et al. A Hepatocyte Growth Factor Receptor (Met)–Insulin Receptor hybrid governs hepatic glucose metabolism , 2011, Nature Medicine.
[62] Yong Liu,et al. PKA phosphorylation couples hepatic inositol-requiring enzyme 1α to glucagon signaling in glucose metabolism , 2011, Proceedings of the National Academy of Sciences.
[63] A. Mari,et al. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. , 2011, The Journal of clinical investigation.
[64] D. Green,et al. Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. , 2011, Cell metabolism.
[65] Y. Barak,et al. Role for PPARγ in obesity‐induced hepatic steatosis as determined by hepatocyte‐ and macrophage‐specific conditional knockouts , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[66] Anne E Carpenter,et al. mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway , 2011, Cell.
[67] Y. Xiong,et al. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. , 2011, Molecular cell.
[68] Derek W. Yecies,et al. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. , 2011, Cell metabolism.
[69] R. Hegele,et al. The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism , 2011, Nature Medicine.
[70] Scott A. Busby,et al. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects , 2011, Nature.
[71] B. Spiegelman,et al. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. , 2011, Genes & development.
[72] S. Kliewer,et al. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway. , 2011, Cell metabolism.
[73] R. Coleman,et al. The role of lipid droplets in metabolic disease in rodents and humans. , 2011, The Journal of clinical investigation.
[74] R. Evans,et al. Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis , 2011, Cell.
[75] Mengwei Zang,et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. , 2011, Cell metabolism.
[76] W. Wahli,et al. Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. , 2011, Cell metabolism.
[77] Xiaoyong Yang,et al. O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver , 2011, Diabetes.
[78] B. Sos,et al. Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. , 2011, The Journal of clinical investigation.
[79] Hui-yu Liu,et al. Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program. , 2011, Endocrinology.
[80] S. Kliewer,et al. FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis , 2011, Science.
[81] Tao Liu,et al. A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism , 2011, Science.
[82] M. White,et al. Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction , 2011, Nature Medicine.
[83] F. Pilleul,et al. Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas. , 2011, Journal of hepatology.
[84] O. Gavrilova,et al. Wnt Signaling Regulates Hepatic Metabolism , 2011, Science Signaling.
[85] M. White,et al. Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. , 2011, American journal of physiology. Endocrinology and metabolism.
[86] Lloyd M. Smith,et al. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. , 2011, Molecular cell.
[87] M. J. Charron,et al. Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice , 2011, Diabetes.
[88] A. Bookout,et al. LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. , 2011, The Journal of clinical investigation.
[89] K. Adeli,et al. C‐reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: Role of mitogen‐activated protein kinases , 2011, Hepatology.
[90] D. Sabatini,et al. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing , 2010, Nature.
[91] F. Alt,et al. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. , 2010, Cell metabolism.
[92] J. Girard,et al. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. , 2010, The Journal of clinical investigation.
[93] P. Saha,et al. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. , 2010, Cell metabolism.
[94] J. Balschi,et al. Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation* , 2010, The Journal of Biological Chemistry.
[95] D. Mashek,et al. Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways[S] , 2010, Journal of Lipid Research.
[96] Yaohui Nie,et al. MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice. , 2010, The Journal of clinical investigation.
[97] R. Kaufman,et al. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells , 2010, Diabetes, obesity & metabolism.
[98] K. Kaestner,et al. FoxOs Function Synergistically to Promote Glucose Production* , 2010, The Journal of Biological Chemistry.
[99] Xiaoling Xu,et al. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. , 2010, Cell metabolism.
[100] T. Veenstra,et al. SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism* , 2010, The Journal of Biological Chemistry.
[101] M. Kay,et al. FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase. , 2010, American journal of physiology. Endocrinology and metabolism.
[102] Dmitri A. Nusinow,et al. Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis , 2010, Nature Medicine.
[103] Min Jae Lee,et al. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. , 2010, Gastroenterology.
[104] Aidan S. Hancock,et al. Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice. , 2010, Molecular endocrinology.
[105] P. Puigserver,et al. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. , 2010, Genes & development.
[106] Young-sil Yoon,et al. Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. , 2010, Cell metabolism.
[107] A. Viale,et al. Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically , 2010, Proceedings of the National Academy of Sciences.
[108] Xin Lu,et al. The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. , 2010, Cell metabolism.
[109] Yixue Li,et al. Regulation of Cellular Metabolism by Protein Lysine Acetylation , 2010, Science.
[110] Shijie Li,et al. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis , 2010, Proceedings of the National Academy of Sciences.
[111] G. Gores,et al. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. , 2010, The Journal of clinical investigation.
[112] M. Montminy,et al. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity , 2010, Proceedings of the National Academy of Sciences.
[113] Robert V Farese,et al. SIRT 3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation , 2010 .
[114] S. Mohanty,et al. Nonalcoholic Fatty Liver Disease: A Review and Update , 2010, Digestive Diseases and Sciences.
[115] G. Shulman,et al. Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. , 2009, Cell metabolism.
[116] A. Mora,et al. Prevention of steatosis by hepatic JNK1. , 2009, Cell metabolism.
[117] L. Rui,et al. Recent advances in understanding leptin signaling and leptin resistance. , 2009, American journal of physiology. Endocrinology and metabolism.
[118] J. Dubé,et al. Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance , 2009, Diabetes.
[119] T. Veenstra,et al. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. , 2009, Cell metabolism.
[120] J. Granneman,et al. Perilipin Controls Lipolysis by Regulating the Interactions of AB-hydrolase Containing 5 (Abhd5) and Adipose Triglyceride Lipase (Atgl)* , 2009, The Journal of Biological Chemistry.
[121] L. Sanderson,et al. Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver , 2009, Molecular and Cellular Biology.
[122] S. Bischoff,et al. Toll‐like receptor 4 is involved in the development of fructose‐induced hepatic steatosis in mice , 2009, Hepatology.
[123] John Turk,et al. Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver , 2009, Cell.
[124] T. Lam,et al. Intestinal cholecystokinin controls glucose production through a neuronal network. , 2009, Cell metabolism.
[125] Shuli Wang,et al. Liver-specific Loss of Long Chain Acyl-CoA Synthetase-1 Decreases Triacylglycerol Synthesis and β-Oxidation and Alters Phospholipid Fatty Acid Composition* , 2009, The Journal of Biological Chemistry.
[126] Sunmin Park,et al. The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis , 2009, Molecular and Cellular Biology.
[127] G. Tuteja,et al. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. , 2009, Cell metabolism.
[128] M. Gillum,et al. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats , 2009, Proceedings of the National Academy of Sciences.
[129] G. Baffy. Kupffer cells in non-alcoholic fatty liver disease: the emerging view. , 2009, Journal of hepatology.
[130] S. Kliewer,et al. FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response , 2009, Proceedings of the National Academy of Sciences.
[131] L. Rui,et al. SH2B1 Enhances Insulin Sensitivity by Both Stimulating the Insulin Receptor and Inhibiting Tyrosine Dephosphorylation of Insulin Receptor Substrate Proteins , 2009, Diabetes.
[132] A. Hollenberg,et al. STAT3 targets the regulatory regions of gluconeogenic genes in vivo. , 2009, Molecular endocrinology.
[133] T. Clemens,et al. Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism*♦ , 2009, The Journal of Biological Chemistry.
[134] F. Wondisford,et al. Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein , 2009, Cell.
[135] M. Montminy,et al. The CREB Coactivator CRTC2 Links Hepatic ER Stress and Fasting Gluconeogenesis , 2009, Nature.
[136] S. Luquet,et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. , 2009, The Journal of clinical investigation.
[137] Takashi Nakagawa,et al. SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle , 2009, Cell.
[138] Sushant Bhatnagar,et al. Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis* , 2009, Journal of Biological Chemistry.
[139] Qing Xu,et al. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. , 2009, Cell metabolism.
[140] M. Dietrich,et al. STAT3 inhibition of gluconeogenesis is downregulated by SirT1 , 2009, Nature Cell Biology.
[141] Hei Sook Sul,et al. A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin , 2009, Cell.
[142] G. Shulman,et al. The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. , 2009, Cell metabolism.
[143] B. Neel,et al. Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress , 2009, Diabetes.
[144] R. Printz,et al. Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats , 2009, Diabetes.
[145] Masahito Watanabe,et al. IN MICE , 2009 .
[146] M. Katze,et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. , 2008, Developmental cell.
[147] A. Mora,et al. A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance , 2008, Science.
[148] S. Najjar,et al. Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. , 2008, Gastroenterology.
[149] P. Saha,et al. Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease , 2008, Science.
[150] D. Drucker,et al. The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting , 2022 .
[151] S. Watkins,et al. Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism , 2008, Cell.
[152] J. Yates,et al. A Fasting Inducible Switch Modulates Gluconeogenesis Via Activator-Coactivator Exchange , 2008, Nature.
[153] K. Gardner,et al. Regulation of Nuclear Import/Export of Carbohydrate Response Element-binding Protein (ChREBP) , 2008, Journal of Biological Chemistry.
[154] U. Klingmüller,et al. The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. , 2008, Cell metabolism.
[155] R. Kulkarni,et al. Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 , 2008, Diabetes.
[156] L. Agius. Glucokinase and molecular aspects of liver glycogen metabolism. , 2008, The Biochemical journal.
[157] Jiandie D. Lin,et al. Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. , 2008, Cell metabolism.
[158] R. DePinho,et al. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. , 2008, Cell metabolism.
[159] S. Kliewer,et al. Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. , 2008, Cell metabolism.
[160] F. Alt,et al. Tissue-specific regulation of SIRT1 by calorie restriction. , 2008, Genes & development.
[161] Robert A. Harris,et al. Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice. , 2008, American journal of physiology. Endocrinology and metabolism.
[162] L. Glimcher,et al. Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1 , 2008, Science.
[163] A. DeAngelis. CEACAM1: A Link Between Insulin and Lipid Metabolism , 2008 .
[164] D. Ron,et al. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. , 2008, Cell metabolism.
[165] A. Chawla,et al. Cidea is associated with lipid droplets and insulin sensitivity in humans , 2008, Proceedings of the National Academy of Sciences.
[166] P. Light,et al. Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production , 2008, Nature.
[167] F. Gonzalez,et al. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. , 2008, Cell metabolism.
[168] S. Hiebert,et al. Liver‐specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks , 2008, The EMBO journal.
[169] Pascale Bossard,et al. ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. , 2008, The Journal of clinical investigation.
[170] J. Qin,et al. Negative regulation of the deacetylase SIRT1 by DBC1 , 2008, Nature.
[171] Junjie Chen,et al. DBC1 is a negative regulator of SIRT1 , 2008, Nature.
[172] M. Miyazaki,et al. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. , 2007, Cell metabolism.
[173] G. Shulman,et al. Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance , 2007, Proceedings of the National Academy of Sciences.
[174] J. Yates,et al. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. , 2007, Nature.
[175] S. Herzig,et al. Glucocorticoids, metabolism and metabolic diseases , 2007, Molecular and Cellular Endocrinology.
[176] R. DePinho,et al. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. , 2007, Cell metabolism.
[177] A. Fukamizu,et al. Foxo1 links insulin signaling to C/EBPα and regulates gluconeogenesis during liver development , 2007, The EMBO journal.
[178] L. Hennighausen,et al. Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration , 2007, Hepatology.
[179] P. Puigserver,et al. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1 , 2007, Proceedings of the National Academy of Sciences.
[180] M. Birnbaum,et al. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator , 2007, Nature.
[181] F. Ashcroft,et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. , 2007, Cell metabolism.
[182] J. Flier,et al. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. , 2007, Cell metabolism.
[183] S. Kliewer,et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. , 2007, Cell metabolism.
[184] R. Eckel,et al. CCAAT/Enhancer-binding Protein β Deletion Reduces Adiposity, Hepatic Steatosis, and Diabetes in Leprdb/db Mice* , 2007, Journal of Biological Chemistry.
[185] B. Lowell,et al. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. , 2007, Cell metabolism.
[186] Jill M. Schroeder-Gloeckler,et al. CCAAT/enhancing binding protein β deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet‐induced nonalcoholic steatohepatitis , 2007, Hepatology.
[187] Minghua Li,et al. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. , 2007, The Journal of clinical investigation.
[188] P. Tso,et al. Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins , 2007, Nature Medicine.
[189] K. Ohbuchi,et al. Hepatic De Novo Lipogenesis Is Present in Liver-Specific ACC1-Deficient Mice , 2007, Molecular and Cellular Biology.
[190] J. Cha,et al. The Liver X Receptor (LXR) and Hepatic Lipogenesis , 2007, Journal of Biological Chemistry.
[191] B. Thiers. Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 , 2007 .
[192] R. Eckel,et al. CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. , 2007, The Journal of biological chemistry.
[193] D. Russell,et al. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. , 2007, Cell metabolism.
[194] G. Hotamisligil,et al. Inflammation and metabolic disorders , 2006, Nature.
[195] T. Osborne,et al. Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase1 Published, JLR Papers in Press, September 6, 2006. , 2006, Journal of Lipid Research.
[196] M. J. Charron,et al. Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia , 2006, Diabetologia.
[197] S. Kennedy,et al. Protection against Western diet–induced obesity and hepatic steatosis in liver fatty acid–binding protein knockout mice , 2006, Hepatology.
[198] J. Flier,et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. , 2006, The Journal of clinical investigation.
[199] J. Qin,et al. SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity , 2006, Cell.
[200] T. Harris,et al. Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway , 2006 .
[201] J. Girard,et al. Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice , 2006, Diabetes.
[202] J. Repa,et al. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. , 2006, Cell metabolism.
[203] Robert A. Harris,et al. Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation. , 2006, The Biochemical journal.
[204] K. Iizuka,et al. Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice. , 2006, American journal of physiology. Endocrinology and metabolism.
[205] T. Friedman,et al. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. , 2006, Endocrinology.
[206] A. M. Etgen,et al. Critical role of STAT3 in leptin's metabolic actions. , 2006, Cell metabolism.
[207] P. Puigserver,et al. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. , 2006, Cell metabolism.
[208] Ziwei Gu,et al. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[209] R. Evans,et al. A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway* , 2006, Journal of Biological Chemistry.
[210] B. Viollet,et al. Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. , 2006, Endocrinology.
[211] Petra C. Kienesberger,et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. , 2006, Cell metabolism.
[212] Janardan K Reddy,et al. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. , 2006, American journal of physiology. Gastrointestinal and liver physiology.
[213] S. Akira,et al. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. , 2006, Cell metabolism.
[214] R. Gimeno,et al. Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. , 2006, Gastroenterology.
[215] G. Shulman,et al. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. , 2006, The Journal of clinical investigation.
[216] Timothy M Willson,et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[217] Xueying Lin,et al. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. , 2006, The Journal of clinical investigation.
[218] T. Harris,et al. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. , 2006, Cell metabolism.
[219] T. Becker,et al. p38 Mitogen-activated Protein Kinase Plays a Stimulatory Role in Hepatic Gluconeogenesis* , 2005, Journal of Biological Chemistry.
[220] R. DePinho,et al. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.
[221] O. Gavrilova,et al. Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. , 2005, The Journal of clinical investigation.
[222] M. Montminy,et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism , 2005, Nature.
[223] S. Kliewer,et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. , 2005, Cell metabolism.
[224] Ziwei Gu,et al. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[225] A. Fukamizu,et al. Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[226] A. Pocai,et al. Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism , 2005, Science.
[227] Minghua Li,et al. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. , 2005, Cell metabolism.
[228] Tiffany A. Miller,et al. Insulin acutely decreases hepatic fatty acid synthase activity. , 2005, Cell metabolism.
[229] Minoru Yoshida,et al. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. , 2005, Molecular cell.
[230] J. Jessurun,et al. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.
[231] J. Schneider,et al. "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. , 2005, Cell metabolism.
[232] Wilhelm Haas,et al. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1 , 2005, Nature.
[233] J. Bryan,et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis , 2005, Nature Medicine.
[234] S. Shoelson,et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB , 2005, Nature Medicine.
[235] Christoph Handschin,et al. Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP , 2005, Cell.
[236] A. Hevener,et al. IKK-beta links inflammation to obesity-induced insulin resistance. , 2005, Nature medicine.
[237] S. Shoelson,et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. , 2005, Nature medicine.
[238] Craig R Malloy,et al. Impaired Tricarboxylic Acid Cycle Activity in Mouse Livers Lacking Cytosolic Phosphoenolpyruvate Carboxykinase* , 2004, Journal of Biological Chemistry.
[239] Yusuke Inoue,et al. Disruption of Hepatic C/EBPα Results in Impaired Glucose Tolerance and Age-dependent Hepatosteatosis* , 2004, Journal of Biological Chemistry.
[240] L. Glimcher,et al. Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.
[241] Minghua Li,et al. SH2-B Promotes Insulin Receptor Substrate 1 (IRS1)- and IRS2-mediated Activation of the Phosphatidylinositol 3-Kinase Pathway in Response to Leptin* , 2004, Journal of Biological Chemistry.
[242] M. White,et al. Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance , 2004, Molecular and Cellular Biology.
[243] Guoxun Chen,et al. Trace: Tennessee Research and Creative Exchange Nutrition Publications and Other Works Nutrition Central Role for Liver X Receptor in Insulin-mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver. Recommended Citation , 2022 .
[244] D. Vertommen,et al. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. , 2004, The Biochemical journal.
[245] Alexandre Reymond,et al. The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. , 2004, Human molecular genetics.
[246] C. Kahn,et al. Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms , 2004, Molecular and Cellular Biology.
[247] C. Kellendonk,et al. Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. , 2004, Molecular endocrinology.
[248] N. Porksen,et al. Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors. , 2004, The Journal of clinical investigation.
[249] F. Wondisford,et al. Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein , 2004, Nature Medicine.
[250] Sander M Houten,et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. , 2004, The Journal of clinical investigation.
[251] K. Iizuka,et al. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[252] H. Towle,et al. Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes* , 2004, Journal of Biological Chemistry.
[253] B. Monia,et al. Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. , 2004, Diabetes.
[254] P. Edwards,et al. Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR , 2004 .
[255] Y. Kido,et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo , 2004, Nature Medicine.
[256] Othon B. Kotoulas,et al. Glycogen autophagy , 2004, Microscopy research and technique.
[257] Xianlin Han,et al. Decreased Hepatic Triglyceride Accumulation and Altered Fatty Acid Uptake in Mice with Deletion of the Liver Fatty Acid-binding Protein Gene* , 2003, Journal of Biological Chemistry.
[258] Ianessa Morantte,et al. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ , 2003, Nature.
[259] M. Reitman,et al. Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass* , 2003, Journal of Biological Chemistry.
[260] P. Scherer,et al. Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0580 Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis , 2022 .
[261] Yu Wang,et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. , 2003, The Journal of clinical investigation.
[262] B. Atshaves,et al. Decreased Liver Fatty Acid Binding Capacity and Altered Liver Lipid Distribution in Mice Lacking the Liver Fatty Acid-binding Protein Gene* , 2003, Journal of Biological Chemistry.
[263] Bruce M. Spiegelman,et al. Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction , 2003, Nature.
[264] B. Wadzinski,et al. Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[265] Bei B. Zhang,et al. Glucagon and regulation of glucose metabolism. , 2003, American journal of physiology. Endocrinology and metabolism.
[266] B. Brewer,et al. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. , 2003, The Journal of clinical investigation.
[267] B. Staels,et al. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. , 2003, Molecular endocrinology.
[268] J. Holst,et al. Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[269] L. Rossetti,et al. Hypothalamic insulin signaling is required for inhibition of glucose production , 2002, Nature Medicine.
[270] M. White,et al. SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2* , 2002, The Journal of Biological Chemistry.
[271] S. Uchida,et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature Medicine.
[272] M. White,et al. IRS proteins and the common path to diabetes. , 2002, American journal of physiology. Endocrinology and metabolism.
[273] B. Yandell,et al. Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[274] N. Socci,et al. Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss , 2002, Science.
[275] Zhaohui Feng,et al. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats , 2002, Nature Neuroscience.
[276] Joseph L Goldstein,et al. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. , 2002, The Journal of clinical investigation.
[277] J. Gustafsson,et al. Liver X Receptors as Insulin-mediating Factors in Fatty Acid and Cholesterol Biosynthesis* , 2002, The Journal of Biological Chemistry.
[278] Y. Kido,et al. CEACAM1 regulates insulin clearance in liver , 2002, Nature Genetics.
[279] Zhaohui Feng,et al. Central administration of oleic acid inhibits glucose production and food intake. , 2002, Diabetes.
[280] J. Stock,et al. Glycemic control in mice with targeted disruption of the glucagon receptor gene. , 2002, Biochemical and biophysical research communications.
[281] C. Kahn,et al. Insulin signalling and the regulation of glucose and lipid metabolism , 2001, Nature.
[282] K. Uyeda,et al. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[283] D. Accili,et al. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. , 2001, The Journal of clinical investigation.
[284] Marc Montminy,et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 , 2001, Nature.
[285] Guillaume Adelmant,et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 , 2001, Nature.
[286] M. Sakurai,et al. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[287] G. Shulman,et al. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[288] Martin M. Matzuk,et al. Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2 , 2001, Science.
[289] R. Bartrons,et al. PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate. , 2001, Trends in biochemical sciences.
[290] Jean-Marc A. Lobaccaro,et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ , 2000 .
[291] D. Mangelsdorf,et al. Role of LXRs in control of lipogenesis. , 2000, Genes & development.
[292] Masahiro Tohkin,et al. Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis , 2000, Cell.
[293] R. Chalkley,et al. Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism , 2000, Molecular and Cellular Biology.
[294] C. Kahn,et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. , 2000, Molecular cell.
[295] Rick B. Vega,et al. The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes , 2000, Molecular and Cellular Biology.
[296] S. Chirala,et al. The subcellular localization of acetyl-CoA carboxylase 2. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[297] I. Shimomura,et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. , 2000, Genes & development.
[298] D. Kelly,et al. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[299] P. Cohen,et al. Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence* , 1999, The Journal of Biological Chemistry.
[300] W. Wahli,et al. Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting , 1999 .
[301] S. Vaulont,et al. Essential Role in Vivo of Upstream Stimulatory Factors for a Normal Dietary Response of the Fatty Acid Synthase Gene in the Liver* , 1999, The Journal of Biological Chemistry.
[302] V. Poli,et al. Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPbeta gene. , 1999, The Journal of clinical investigation.
[303] M. Magnuson,et al. Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase* , 1999, The Journal of Biological Chemistry.
[304] W. Wahli,et al. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. , 1999, The Journal of clinical investigation.
[305] M. Takiguchi,et al. Hypoglycemia-associated Hyperammonemia Caused by Impaired Expression of Ornithine Cycle Enzyme Genes in C/EBPα Knockout Mice* , 1998, The Journal of Biological Chemistry.
[306] W. Duckworth,et al. Insulin degradation: progress and potential. , 1998, Endocrine reviews.
[307] M. Stumvoll,et al. Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus. , 1998, The Journal of clinical investigation.
[308] D. Mangelsdorf,et al. An oxysterol signalling pathway mediated by the nuclear receptor LXRα , 1996, Nature.
[309] J. Reddy,et al. Hepatocellular and Hepatic Peroxisomal Alterations in Mice with a Disrupted Peroxisomal Fatty Acyl-coenzyme A Oxidase Gene* , 1996, The Journal of Biological Chemistry.
[310] A. Bradley,et al. Impaired energy homeostasis in C/EBP alpha knockout mice , 1995, Science.
[311] K. Mikoshiba,et al. The inositol 1,4,5-trisphosphate receptor. , 1992, Ciba Foundation symposium.
[312] R. Shulman,et al. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. , 1992, The Journal of clinical investigation.
[313] D. Wasserman,et al. Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. , 1989, The American journal of physiology.
[314] F. Capani,et al. Predominant Role of Gluconeogenesis in Increased Hepatic Glucose Production in NIDDM , 1989, Diabetes.