Modelling and Regularity of Nonlinear Impulsive Switching Dynamical System in Fed-Batch Culture

A hybrid system with state-based switchings is proposed to describe the fed-batch production of 1,3-propandiol from glycerol in our previous work. However, the on-off switching of alkali is too frequent, which greatly increases the computational cost of the numerical solution to the system so as to locate the state-based switchings in strict time order and implement the correct mode changes. To deal with this problem, we consider the switching of alkali pump as an impulsive event and present a nonlinear impulsive switching system to describe the fed-batch culture. It is proved that the impulsive switching system is non-Zeno. Some basic properties of solutions to the impulsive switching system are also explored. In order to overcome the discontinuities of the system, the Skorohod topology is induced and a specific form of λ is constructed to prove the main theorem. Additionally, a numerical simulation is carried out to show that the proposed system can describe the fed-batch culture properly and the essential difference with the previous work.

[1]  H. Biebl,et al.  Production of 1,3-propanediol by Clostridium butyricum DSM 5431 and product tolerant mutants in fedbatch culture: Feeding strategy for glycerol and ammonium , 1996, Biotechnology Letters.

[2]  Wolf-Dieter Deckwer,et al.  Glycerol conversion to 1,3-propanediol by newly isolated clostridia , 1992, Applied Microbiology and Biotechnology.

[3]  E. Feng,et al.  MODELLING AND OPTIMAL CONTROL FOR NONLINEAR MULTISTAGE DYNAMICAL SYSTEM OF MICROBIAL FED-BATCH CULTURE , 2009 .

[4]  Behzad Moshiri,et al.  Optimal control of a nonlinear fed-batch fermentation process using model predictive approach , 2009 .

[5]  Enmin Feng,et al.  Modelling and well-posedness of a nonlinear hybrid system in fed-batch production of 1,3-propanediol with open loop glycerol input and pH logic control , 2011 .

[6]  A. Zeng,et al.  A Kinetic Model for Substrate and Energy Consumption of Microbial Growth under Substrate‐Sufficient Conditions , 1995, Biotechnology progress.

[7]  V. Lakshmikantham,et al.  Theory of Impulsive Differential Equations , 1989, Series in Modern Applied Mathematics.

[8]  Enmin Feng,et al.  Modeling and parameter identification of microbial bioconversion in fed-batch cultures , 2008 .

[9]  R. Bass,et al.  Review: P. Billingsley, Convergence of probability measures , 1971 .

[10]  Wolf-Dieter Deckwer,et al.  Fermentation of glycerol to 1,3-propanediol by Klebsiella and Citrobacter strains , 1990, Applied Microbiology and Biotechnology.

[11]  Guang-Ren Duan,et al.  Optimal piecewise state feedback control for impulsive switched systems , 2008, Math. Comput. Model..

[12]  Wolf-Dieter Deckwer,et al.  Synthesis, properties and biodegradability of polyesters based on 1,3‐propanediol , 1994 .

[13]  Zong-ming Zheng,et al.  3-Hydroxypropionaldehyde guided glycerol feeding strategy in aerobic 1,3-propanediol production by Klebsiella pneumoniae , 2008, Journal of Industrial Microbiology & Biotechnology.

[14]  A. Zeng,et al.  Multiple product inhibition and growth modeling of clostridium butyricum and klebsiella pneumoniae in glycerol fermentation , 1994, Biotechnology and bioengineering.