Lifelong feeding of a high aluminum diet to mice.

In three experiments, high aluminum diets (1000 microg Al/g diet) were fed to mice throughout their life span to determine whether neurodegenerative changes were seen with aging. Brain Al concentrations were slightly lower in Al-treated mice than controls. Generally, no increased mortality or gross evidence of neurodegeneration was seen in Al-treated mice. Eighteen and 24 month old Swiss Webster mice fed the high aluminum diet differed from controls on some neurobehavioral tests, but differences were no greater than previously seen with shorter term exposure in younger mice. Both brain Al concentration and susceptibility to oxidative damage, as measured with TBARS, were lower in the Al-treated aged mice than in controls. In addition, Al-treated aged Swiss Webster and C57BL/6J mice showed somewhat enhanced performance in the Morris water maze. Finally, Al treatment did not exacerbate the effect of MPTP treatment on a grip strength measure in either 66 or 235 day old male mice. Swiss Webster and C57BL/6J mice do not appear to provide useful models for studying Al-induced neurodegenerative changes in aging.

[1]  J. Domingo,et al.  The effect of age on aluminum retention in rats. , 1997, Toxicology.

[2]  M. Golub,et al.  Iron and manganese uptake by offspring of lactating mice fed a high aluminum diet. , 1996, Toxicology.

[3]  P. Schramel,et al.  Trace element analytical chemistry in medicine and biology , 1980 .

[4]  M. Golub,et al.  Aluminum alters iron and manganese uptake and regulation of surface transferrin receptors in primary rat oligodendrocyte cultures , 1996, Brain Research.

[5]  M. Golub,et al.  Effects of dietary aluminum excess and manganese deficiency on neurobehavioral endpoints in adult mice. , 1992, Toxicology and applied pharmacology.

[6]  M. Golub,et al.  Developmental patterns of aluminum in mouse brain and effects of dietary aluminum excess on manganese deficiency. , 1993, Toxicology.

[7]  S. Phinney,et al.  Ethanol‐induced changes in hepatic free radical defense mechanisms and fatty‐acid composition in the miniature pig , 1991, Hepatology.

[8]  M. Golub,et al.  Behavioral performance of Swiss Webster mice exposed to excess dietary aluminum during development or during development and as adults. , 1995, Toxicology and applied pharmacology.

[9]  M. Golub,et al.  Aluminum accumulation and neurotoxicity in Swiss-Webster mice after long-term dietary exposure to aluminum and citrate. , 1993, Metabolism: clinical and experimental.

[10]  M. Golub,et al.  Auditory startle in Swiss Webster mice fed excess aluminum in diet. , 1994, Neurotoxicology and teratology.

[11]  Y. Lamberty,et al.  Simplifying environmental cues in a Morris-type water maze improves place learning in old NMRI mice. , 1991, Behavioral and neural biology.

[12]  M. Golub,et al.  Aluminum effects on operant performance and food motivation of mice. , 1998, Neurotoxicology and teratology.

[13]  M. Golub,et al.  Perinatal bupivacaine and infant behavior in rhesus monkeys. , 1998, Neurotoxicology and teratology.

[14]  M. Golub,et al.  Effects of aluminum ingestion on spontaneous motor activity of mice. , 1989, Neurotoxicology and teratology.

[15]  M. Golub,et al.  Effects of aluminum on brain lipid peroxidation. , 1990, Toxicology letters.

[16]  M. Golub,et al.  Neurobehavioral effects in offspring of mice given excess aluminum in diet during gestation and lactation. , 1989, Neurotoxicology and teratology.

[17]  M. Golub,et al.  Myelin is a preferential target of aluminum-mediated oxidative damage. , 1997, Archives of biochemistry and biophysics.

[18]  Y. Lamberty,et al.  Cholinergic modulation of spatial learning in mice in a Morris-type water maze. , 1991, Archives internationales de pharmacodynamie et de therapie.

[19]  B. Hoffer,et al.  Acidic and basic fibroblast growth factor mRNAs are increased in striatum following MPTP-induced dopamine neurofiber lesion: assay by quantitative PCR. , 1993, Brain research. Molecular brain research.

[20]  M. Golub,et al.  Neurodevelopmental effect of aluminum in mice: fostering studies. , 1992, Neurotoxicology and teratology.

[21]  W. D. Ehmann,et al.  Instrumental neutron activation analysis of brain aluminum in Alzheimer disease and aging , 1981, Annals of neurology.

[22]  Robert A. Yokel,et al.  Research issues in aluminum toxicity , 1997 .

[23]  M. Clauberg,et al.  Effects of Prolonged Chronic Dietary Treatment with AlCl3 on Selected Metabolisms and Memory in Rats , 1992, Annals of the New York Academy of Sciences.