Automatic Retinal Vessel Extraction Algorithm

Retinal vessel segmentation plays a key role in the detection of numerous eye diseases, and its reliable computerised implementation becomes important for automatic retinal disease screening systems. A large number of retinal vessel segmentation algorithms have been reported, primarily based on three main steps including uniforming background, using the second-order Gaussian detector and applying binarization. These methods though improve the accuracy levels, their sensitivity to low-contrast in vessels still needs attention. In this paper, some contrast-sensitive approaches are discussed and embedded in the conventional algorithms, resulting in improved sensitivity for a given retinal vessel extraction technique. The proposed method gives good performance on both publicly databases with the accurate vessel extraction on STARE database. The proposed unsupervised method achieves the accuracy of 94.41%, much better than some existing unsupervised methods and comparable to some supervised methods. Its efficiency with different image conditions, together with its simplicity and fast operation, makes the blood vessel segmentation application suitable for retinal image computer analyses such as automated screening for early diabetic retinopathy detection.

[1]  R. Klein,et al.  Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. , 1999, Ophthalmology.

[2]  Roberto Marcondes Cesar Junior,et al.  Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification , 2005, IEEE Transactions on Medical Imaging.

[3]  Bram van Ginneken,et al.  Comparative study of retinal vessel segmentation methods on a new publicly available database , 2004, SPIE Medical Imaging.

[4]  John Flynn,et al.  Characterization of changes in blood vessel width and tortuosity in retinopathy of prematurity using image analysis , 2002, Medical Image Anal..

[5]  I. Deary,et al.  Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures , 2005, Journal of anatomy.

[6]  Roberto Marcondes Cesar Junior,et al.  Retinal Vessel Segmentation Using the 2-D Morlet Wavelet and Supervised Classification , 2005, ArXiv.

[7]  Katsuya Hirano,et al.  Cellular mechanism of vasoconstriction induced by angiotensin II: it remains to be determined. , 2003, Circulation research.

[8]  Xiaoyi Jiang,et al.  Adaptive Local Thresholding by Verification-Based Multithreshold Probing with Application to Vessel Detection in Retinal Images , 2003, IEEE Trans. Pattern Anal. Mach. Intell..

[9]  Elliot J. Sussman,et al.  Diagnosis of Diabetic Eye Disease-Reply , 1982 .

[10]  Bunyarit Uyyanonvara,et al.  An Ensemble Classification-Based Approach Applied to Retinal Blood Vessel Segmentation , 2012, IEEE Transactions on Biomedical Engineering.

[11]  Kamel Hamrouni,et al.  Detection of Blood Vessels in Retinal Images , 2010, Int. J. Image Graph..

[12]  Junbin Gao,et al.  Study of the Noise Level in the Colour Fundus Images , 2015, ICDS.

[13]  Tariq M. Khan,et al.  Efficient hardware implementation strategy for local normalization of fingerprint images , 2016, Journal of Real-Time Image Processing.

[14]  Dogan Aydin,et al.  Detection of blood vessels in ophthalmoscope images using MF/ant (matched filter/ant colony) algorithm , 2009, Comput. Methods Programs Biomed..

[15]  Hong Yan,et al.  A Novel Vessel Segmentation Algorithm for Pathological Retina Images Based on the Divergence of Vector Fields , 2008, IEEE Transactions on Medical Imaging.

[16]  S. Vijayachitra,et al.  Extraction of Retinal Blood Vessels and Diagnosis of Proliferative Diabetic Retinopathy Using Extreme Learning Machine , 2015 .

[17]  Garrison W. Cottrell,et al.  Color-to-Grayscale: Does the Method Matter in Image Recognition? , 2012, PloS one.

[18]  Yong Yang,et al.  An Automatic Hybrid Method for Retinal Blood Vessel Extraction , 2008, Int. J. Appl. Math. Comput. Sci..

[19]  Ana Maria Mendonça,et al.  Segmentation of retinal blood vessels by combining the detection of centerlines and morphological reconstruction , 2006, IEEE Transactions on Medical Imaging.

[20]  A.D. Hoover,et al.  Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response , 2000, IEEE Transactions on Medical Imaging.

[21]  P. Bankhead,et al.  Fast Retinal Vessel Detection and Measurement Using Wavelets and Edge Location Refinement , 2012, PloS one.

[22]  Yinan Kong,et al.  Real-time edge detection and range finding using FPGAs , 2015 .

[23]  Zhen Chen,et al.  Morphological Multiscale Enhancement, Fuzzy Filter and Watershed for Vascular Tree Extraction in Angiogram , 2011, Journal of Medical Systems.

[24]  Max A. Viergever,et al.  Ridge-based vessel segmentation in color images of the retina , 2004, IEEE Transactions on Medical Imaging.

[25]  Lili Xu,et al.  A novel method for blood vessel detection from retinal images , 2010, Biomedical engineering online.

[26]  Evangelos Dermatas,et al.  Multi-scale retinal vessel segmentation using line tracking , 2010, Comput. Medical Imaging Graph..

[27]  Junbin Gao,et al.  Non-Invasive Contrast Normalisation and Denosing Technique for the Retinal Fundus Image , 2016 .

[28]  R. Klein,et al.  Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations. , 2007, European heart journal.

[29]  Giri Babu Kande,et al.  Unsupervised Fuzzy Based Vessel Segmentation In Pathological Digital Fundus Images , 2010, Journal of Medical Systems.

[30]  Frédéric Zana,et al.  Segmentation of vessel-like patterns using mathematical morphology and curvature evaluation , 2001, IEEE Trans. Image Process..