Effects of 6-month, Multimodal Exercise Program on Clinical and Gait Parameters of Patients with Idiopathic Parkinson's Disease: A Pilot Study

This pilot study aimed to identify the effects of a 6-month, multimodal exercise program on clinical and gait parameters in patients with Parkinson's disease. Two groups of participants were enrolled in the study: Trained Group (TG) and Control Group (CG). Individuals in the TG exercised three times a week for 24 weeks (in a multimodal exercise program), while the CG participants maintained their regular activity level. Participants in both the TG and the CG were assessed at pre- and posttest by clinical rates and the spatiotemporal parameters of self-paced walking. The two groups were not significantly different in demographic, clinical, and gait data at baseline. There were no significant differences between groups for clinical data at posttest. The purposed multimodal exercise program has found improvement in some kinematic gait parameters for the TG. Further study in the form of randomized controlled trial would be required to establish effectiveness of the intervention.

[1]  Susan E. Hardy,et al.  Improvement in Usual Gait Speed Predicts Better Survival in Older Adults , 2007, Journal of the American Geriatrics Society.

[2]  Ichiro Miyai,et al.  Long-term effect of body weight-supported treadmill training in Parkinson's disease: a randomized controlled trial. , 2002, Archives of physical medicine and rehabilitation.

[3]  D. Aarsland,et al.  Progression of motor impairment and disability in Parkinson disease , 2005, Neurology.

[4]  K. Marder,et al.  Progression of parkinsonian signs in Parkinson disease. , 1999, Archives of neurology.

[5]  E. Katunina,et al.  [Epidemiology of Parkinson's disease]. , 2013, Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.

[6]  B. Winblad,et al.  Changes in Motor Performance in Persons with Parkinson's Disease After Exercise in a Mountain Area , 1997, The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses.

[7]  Florindo Stella,et al.  Effects of postural threat on walking features of Parkinson's disease patients , 2009, Neuroscience Letters.

[8]  Q. Almeida,et al.  A positive influence of vision on motor symptoms during sensory attention focused exercise for Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.

[9]  M. Hoehn,et al.  Parkinsonism , 1967, Neurology.

[10]  Ray-Yau Wang,et al.  Relationships between gait and dynamic balance in early Parkinson's disease. , 2008, Gait & posture.

[11]  F. Stella,et al.  Exercise programs improve mobility and balance in people with Parkinson's disease. , 2009, Parkinsonism & related disorders.

[12]  Q. Almeida,et al.  Symptom and gait changes after sensory attention focused exercise vs aerobic training in Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[13]  S. Rubin,et al.  Prognostic Value of Usual Gait Speed in Well‐Functioning Older People—Results from the Health, Aging and Body Composition Study , 2005, Journal of the American Geriatrics Society.

[14]  Paulo Caramelli,et al.  Sugestões para o uso do mini-exame do estado mental no Brasil , 2003 .

[15]  I. Miyai,et al.  Treadmill training with body weight support: its effect on Parkinson's disease. , 2000, Archives of physical medicine and rehabilitation.

[16]  Katy Mitchell,et al.  Gait and step training to reduce falls in Parkinson's disease. , 2005, NeuroRehabilitation.

[17]  R. Vitório,et al.  Effects of obstacle height on obstacle crossing in mild Parkinson's disease. , 2010, Gait & posture.

[18]  Houeto Jean-Luc [Parkinson's disease]. , 2022, La Revue du praticien.

[19]  Marcos Duarte,et al.  Biomechanical characteristics of elderly individuals walking on land and in water. , 2008, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[20]  J. Larsen,et al.  Health related quality of life in Parkinson's disease: a prospective longitudinal study , 2000, Journal of neurology, neurosurgery, and psychiatry.

[21]  M. Morris,et al.  Three‐dimensional gait biomechanics in Parkinson's disease: Evidence for a centrally mediated amplitude regulation disorder , 2005, Movement disorders : official journal of the Movement Disorder Society.

[22]  Michael R. Wells,et al.  Resistance Training and Gait Function in Patients with Parkinson’s Disease , 2001, American journal of physical medicine & rehabilitation.

[23]  Ricardo M. L. Barros,et al.  A flexible software for tracking of markers used in human motion analysis , 2003, Comput. Methods Programs Biomed..

[24]  S. Fahn Unified Parkinson's Disease Rating Scale , 1987 .

[25]  S. Fahn Members of the UPDRS Development Committee. Unified Parkinson's Disease Rating Scale , 1987 .

[26]  Adrian H. Taylor,et al.  The effectiveness of exercise interventions for people with Parkinson's disease: A systematic review and meta‐analysis , 2008, Movement disorders : official journal of the Movement Disorder Society.

[27]  W De Weerdt,et al.  The effect of a home physiotherapy program for persons with Parkinson's disease. , 2001, Journal of rehabilitation medicine.

[28]  H. Erdem,et al.  The effects of incremental speed-dependent treadmill training on postural instability and fear of falling in Parkinson's disease , 2007, Clinical rehabilitation.

[29]  F. Stella,et al.  Benefits of physical exercise on executive functions in older people with Parkinson’s disease , 2009, Brain and Cognition.

[30]  F. Stella,et al.  Quality of life (QoL) in relation to disease severity in Brazilian Parkinson's patients as measured using the WHOQOL-BREF. , 2008, Archives of gerontology and geriatrics.

[31]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[32]  Ricardo Nitrini,et al.  [Suggestions for utilization of the mini-mental state examination in Brazil]. , 2003, Arquivos de neuro-psiquiatria.

[33]  P. Caramelli,et al.  Parkinsonism and Parkinson's disease in the elderly: A community‐based survey in Brazil (the Bambuí study) , 2006, Movement disorders : official journal of the Movement Disorder Society.

[34]  A. Bonnet,et al.  [The Unified Parkinson's Disease Rating Scale]. , 2000, Revue neurologique.