Nephrotic Syndrome due to Nodular Glomerulosclerosis in a Non-Diabetic Lung Transplant Recipient with Cystic Fibrosis

Background: Nephrotic syndrome due to severe nodular glomerulosclerosis in a non-diabetic cystic fibrosis (CF) patient is uncommon and is rarely discovered after lung transplantation (LTx). Case: A 34-year-old non-smoker Caucasian woman with a history of CF end-stage lung disease underwent LTx in 2013. Five years later, she developed nephrotic syndrome. The renal biopsy revealed nodular glomerulosclerosis, very similar to diabetic glomerulosclerosis. However the patient did not show any abnormality in blood glucose regulation. Conclusion: Kidney diseases other than calcineurin-inhibitor nephrotoxicity can develop in CF LTx patients. A thorough clin-ico-pathological assessment is essential to guide the diagnosis and an early treatment in a patient with multiple risk factors for kidney diseases

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