Explicit Solutions for Replicator-Mutator Equations: Extinction versus Acceleration

We consider a class of nonlocal reaction-diffusion problems, referred to as replicator-mutator equations in evolutionary genetics. By using explicit changes of unknown function, we show that they are equivalent to the heat equation and, therefore, compute their solution explicitly. Based on this, we then prove that, in the case of beneficial mutations in asexual populations, solutions dramatically depend on the tails of the initial data: they can be global, become extinct in finite time or, even, be defined for no positive time. In the former case, we prove that solutions are accelerating, and in many cases converge for large time to some universal Gaussian profile. This sheds light on the biological relevance of such models.

[1]  Walter Thirring,et al.  A Course in Mathematical Physics 3 , 1981 .

[2]  A. Grigor’yan Heat Kernel and Analysis on Manifolds , 2012 .

[3]  H. Muller Some Genetic Aspects of Sex , 1932, The American Naturalist.

[4]  Walter Thirring,et al.  A Course in Mathematical Physics , 1978 .

[5]  F. Dannan,et al.  The Asymptotic Stability of , 2004 .

[6]  Vadim N Biktashev A simple mathematical model of gradual Darwinian evolution: emergence of a Gaussian trait distribution in adaptation along a fitness gradient , 2014, Journal of mathematical biology.

[7]  J. Coffin,et al.  The solitary wave of asexual evolution , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[8]  R. Feynman,et al.  Quantum Mechanics and Path Integrals , 1965 .

[9]  Odo Diekmann,et al.  A beginners guide to adaptive dynamics , 2002 .

[10]  B. Perthame Transport Equations in Biology , 2006 .

[11]  C. Wilke,et al.  The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation. , 2007, Theoretical population biology.

[12]  Walter Thirring,et al.  A Course in Mathematical Physics 3: Quantum Mechanics of Atoms and Molecules , 1999 .

[13]  B. Perthame,et al.  Dirac Mass Dynamics in Multidimensional Nonlocal Parabolic Equations , 2010, 1011.1768.

[14]  L. Hörmander The analysis of linear partial differential operators , 1990 .

[15]  B. Perthame,et al.  The dynamics of adaptation: an illuminating example and a Hamilton-Jacobi approach. , 2005, Theoretical population biology.

[16]  H. Muller THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE. , 1964, Mutation research.

[17]  Kessler,et al.  RNA virus evolution via a fitness-space model. , 1996, Physical review letters.

[18]  R'emi Carles,et al.  Nonlinear Schrodinger equation with time dependent potential , 2009, 0910.4893.

[19]  Yoh Iwasa,et al.  Evolutionary Branching in a Finite Population: Deterministic Branching vs. Stochastic Branching , 2013, Genetics.

[20]  U. Dieckmann,et al.  The Dynamical Theory of Coevolution : A Derivation from Stochastic Ecological Processes , 1996 .

[21]  E. M. Lifshitz,et al.  Quantum mechanics: Non-relativistic theory, , 1959 .

[22]  Daniel Platt,et al.  Diffusion Limited Aggregation , 1995 .

[23]  A. Perelson,et al.  Complete genetic linkage can subvert natural selection , 2007, Proceedings of the National Academy of Sciences.

[24]  Frank Merle,et al.  Blow up for the critical gKdV equation III: exotic regimes , 2012, 1209.2510.

[25]  P. Sniegowski,et al.  Beneficial mutations and the dynamics of adaptation in asexual populations , 2010, Philosophical Transactions of the Royal Society B: Biological Sciences.

[26]  B. Perthame,et al.  Evolution of species trait through resource competition , 2012, Journal of mathematical biology.

[27]  R. H.J.MULLE THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE , 2002 .