Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

[1]  G. Sieck,et al.  Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle. , 2014, American journal of physiology. Lung cellular and molecular physiology.

[2]  L. O’Neill,et al.  Succinate: a metabolic signal in inflammation. , 2014, Trends in cell biology.

[3]  I. Adcock,et al.  A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model. , 2014, Clinical science.

[4]  C. Frezza.  The role of mitochondria in the oncogenic signal transduction. , 2014, The international journal of biochemistry & cell biology.

[5]  I. Adcock,et al.  Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma. , 2013, American journal of respiratory cell and molecular biology.

[6]  S. Archer.  Mitochondrial dynamics--mitochondrial fission and fusion in human diseases. , 2013, The New England journal of medicine.

[7]  M. Harper,et al.  Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics. , 2013, Trends in biochemical sciences.

[8]  I. Adcock,et al.  Effects of N-Acetylcysteine in Ozone-Induced Chronic Obstructive Pulmonary Disease Model , 2013, PloS one.

[9]  Sina Zarrintan,et al.  Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells , 2013, Respiratory Research.

[10]  James G. Martin,et al.  Mechanisms of airway remodeling. , 2013, Chest.

[11]  Katsutoshi Nakayama,et al.  Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence. , 2013, American journal of physiology. Lung cellular and molecular physiology.

[12]  Michael A Thompson,et al.  Mitochondria in lung diseases , 2013, Expert review of respiratory medicine.

[13]  R. Wood‐Baker,et al.  Recent advances in understanding inflammation and remodeling in the airways in chronic obstructive pulmonary disease , 2013, Expert review of respiratory medicine.

[14]  H. Osiewacz,et al.  Mitochondrial Quality Control: Impact on Aging and Life Span - A Mini-Review , 2013, Gerontology.

[15]  F. Martinez,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.

[16]  T. Koshiba.  Mitochondrial-mediated antiviral immunity. , 2013, Biochimica et biophysica acta.

[17]  A. Cohen,et al.  Acute effects of ambient ozone on mortality in Europe and North America: results from the APHENA study , 2013, Air Quality, Atmosphere & Health.

[18]  I. Rahman,et al.  Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs. , 2012, American journal of physiology. Lung cellular and molecular physiology.

[19]  K. Chung,et al.  Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma. , 2012, The Journal of allergy and clinical immunology.

[20]  W. MacNee,et al.  Antioxidant pharmacological therapies for COPD. , 2012, Current opinion in pharmacology.

[21]  B. Oliver,et al.  TGF-β enhances deposition of perlecan from COPD airway smooth muscle. , 2012, American journal of physiology. Lung cellular and molecular physiology.

[22]  K. Chung,et al.  Transforming growth factor-β and nuclear factor E2–related factor 2 regulate antioxidant responses in airway smooth muscle cells: role in asthma. , 2011, American journal of respiratory and critical care medicine.

[23]  Min Zhang,et al.  A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice. , 2011, American journal of physiology. Lung cellular and molecular physiology.

[24]  K. Chung,et al.  TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells , 2010, American journal of physiology. Lung cellular and molecular physiology.

[25]  K. Chung,et al.  Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids , 2010, European Respiratory Journal.

[26]  Robin A. J. Smith,et al.  Animal and human studies with the mitochondria‐targeted antioxidant MitoQ , 2010, Annals of the New York Academy of Sciences.

[27]  S. Moncada,et al.  Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia. , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[28]  U. Mabalirajan,et al.  Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. , 2009, Journal of applied physiology.

[29]  U. Mabalirajan,et al.  Esculetin Restores Mitochondrial Dysfunction and Reduces Allergic Asthma Features in Experimental Murine Model1 , 2009, The Journal of Immunology.

[30]  P. Barnes,et al.  COPD as a disease of accelerated lung aging(a). , 2009, Revista portuguesa de pneumologia.

[31]  R. Rizzuto,et al.  The Mitochondrial Antioxidants MitoE2 and MitoQ10 Increase Mitochondrial Ca2+ Load upon Cell Stimulation by Inhibiting Ca2+ Efflux from the Organelle , 2008, Annals of the New York Academy of Sciences.

[32]  U. Mabalirajan,et al.  Mitochondrial Structural Changes and Dysfunction Are Associated with Experimental Allergic Asthma1 , 2008, The Journal of Immunology.

[33]  Peng Huang,et al.  Redox regulation of cell survival. , 2008, Antioxidants & redox signaling.

[34]  I. Adcock,et al.  Hydrogen Peroxide Prolongs Nuclear Localization of NF-κB in Activated Cells by Suppressing Negative Regulatory Mechanisms* , 2008, Journal of Biological Chemistry.

[35]  I. Adcock,et al.  Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction , 2008, European Respiratory Journal.

[36]  M. Ichinose,et al.  Oxidative and nitrative stress in bronchial asthma. , 2008, Antioxidants and Redox Signaling.

[37]  J. Vernejoux,et al.  Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma , 2007, The Journal of experimental medicine.

[38]  I. Adcock,et al.  Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. , 2007, Journal of applied physiology.

[39]  I. Adcock,et al.  Attenuation of Ozone-Induced Airway Inflammation and Hyper-Responsiveness by c-Jun NH2 Terminal Kinase Inhibitor SP600125 , 2007, Journal of Pharmacology and Experimental Therapeutics.

[40]  W. M. Foster,et al.  Ozone and pulmonary innate immunity. , 2007, Proceedings of the American Thoracic Society.

[41]  K. Houk,et al.  Free radical biology and medicine: it's a gas, man! , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[42]  I. Adcock,et al.  Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. , 2006, The Journal of allergy and clinical immunology.

[43]  Mark E. Eiswerth,et al.  Impacts of ozone on the activities of asthmatics: revisiting the data. , 2005, Journal of environmental management.

[44]  K. Chung.  The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease. , 2005, Proceedings of the American Thoracic Society.

[45]  M. Rigoulet,et al.  Aging and oxidative stress: studies of some genes involved both in aging and in response to oxidative stress. , 2001, Respiration physiology.

[46]  M. Haida,et al.  Muscle energy metabolism and nutritional status in patients with chronic obstructive pulmonary disease. A 31P magnetic resonance study. , 1995, American journal of respiratory and critical care medicine.

[47]  A. Benabid,et al.  Metabolism and aerobic capacity of skeletal muscle in chronic respiratory failure related to chronic obstructive pulmonary disease. , 1992, The European respiratory journal.