The Dongping gold deposit is located on the northern margin of the North China Craton, and is the largest alkaline pluton-related gold deposit in China (Bao et al., 2014), which is characterized by its large amounts of tellurides. The deposit is largely hosted in the Shuiquangou syenitic complex and consists of auriferous quartz veins and disseminated sulfide ores. It has been extensively studied since its discovery in the 1980s; however the geochronology and genesis of the deposit are still controversial. Nie (1998) considered that the deposit was formed in the Devonian, and metallogenic materials and ore fluids were derived from the Shuiquangou syenitic complex. Hart et al. (2002) suggested that the syenitic complex served merely as the host rock because of a more than 200 m.y. gap between the crystallization age of the syenitic complex (~390 Ma) and the Ar-Ar age of hydrothermal mica (153 Ma). Bao et al. (2014) preferred the Dongping gold deposit represented a Devonian Au mineralization event with a Jurassic–Cretaceous hydrothermal overprinting. The lack of consistent age constraints has hampered the understanding of the genesis of the Dongping gold deposit. In this paper, we present Re-Os isotopic data of molybdenite collected from the Dongping gold deposit, with the goals to discuss relationships between the formation of molybdenite and gold mineralization and to shed new lights on the genesis of this deposit.