Prevalence of metabolic syndrome among psoriasis and lichen planus patients attending tertiary care hospital in Bundelkhand region: A prospective study

Background: Metabolic syndrome is constellation of many different disorders. The common conditions associated with metabolic syndrome are obesity, hypertension, dyslipidemia and insulin resistance. These conditions do play some role in developing cardiovascular disease beyond traditional risk. Metabolic syndrome have been commonly seen in patients of many skin diseases including psoriasis, lichen planus, acne inversa and even in skin malignancies. In chroni skin disorder and even in metabolic syndrome chronic inflammation has been shown to play some role in the pathogenesis of disease. The present study is designed with a view to know any association between skin diseases especially psoriasis and metabolic syndrome, as well as expression of C-reactive protein in psoriasis and other skin diseases in this region. Materials and Methods: Present study was conducted on 76 histopathologically confirmed cases of Psoariasis & Lichen Planus and 70 age and sex matched controls with skin lesions other than psoriasis and lichen planus. For metabolic syndrome criteria proposed by National cholesterol education programme (NCEP) ATP III was used. Triglycerides, HDL cholesterol, Blood sugar and CRP level was quantitatively determined on serum/plasma of patients. Chi square test and SPSS 19.0 software was used for statistical analysis. Results: Among psoriasis patients 18/52 had metabolic syndrome while this figure was low in lichen planus patients 7/24. The incidence of metabolic syndrome with skin disease was high as compared to control population and it was also statistically significant. Cases (psoriasis and lichen planus) with metabolic syndrome had high CRP value 61.1% (11/18) and 57.1% (04/07) respectively as compared to control 12.8% (09/71) and also displayed significant association. Conclusion: It was concluded from this study that metabolic syndrome is an important co-morbidity with psoriasis and lichen planus which requires screening to avoid complications in later life.