The CAN bus which has been widely used in electric vehicle control system have many characteristics such as high transmission efficiency, high reliability, good real-time feature and so on. The CANoe which is the product of German company vector is a practical and powerful tool for system design and analysis. Firstly, a design scheme of simulation and test system for vehicle body CAN bus network is brought forward, which mainly includes the topology of network, the hierarchical model of network and the selection of bus baud rate. Secondly, a method of how to use CANoe to construct the simulation and test environment for vehicle body CAN bus system is introduced Finally, the simulation and test system for vehicle body CAN bus is completed by CANoe. Experiments demonstrate that the development method of simulation and test system is feasible.