Matrix effects in (ultra)trace analysis of pesticide residues in food and biotic matrices.

If one has to determine multiple residues of modem pesticides and/or other groups of (semi)polar and/or thermally unstable contaminants with a wide range of physico-chemical properties within a single analytical run, it can be complicated to obtain low limits of quantitation (LOQ), good precision as well as relevant trueness of results for all the target analytes. Matrix components, which are unavoidably present in analyzed samples (even after the thorough clean-up step), may be responsible for miscellaneous adverse affects impairing different stages of the GC and/or LC determinative step. In this review, the nature of various types of matrix effects are discussed together with suggestions for prevention, reduction and/or compensation of their occurrence when determining troublesome analytes in foods and other complex biotic matrices.

[1]  Andrew L. Lee,et al.  A Model of Peak Amplitude Enhancement in Orthogonal Two-Dimensional Gas Chromatography , 2001 .

[2]  A. Amirav,et al.  Pesticide analysis with the pulsed-flame photometer detector and a direct sample introduction device. , 1997, Analytical chemistry.

[3]  D. Hercules,et al.  Effect of liquid chromatography separation of complex matrices on liquid chromatography-tandem mass spectrometry signal suppression. , 2001, Journal of chromatography. A.

[4]  J. Qu,et al.  Determination of scutellarin in Erigeron breviscapus extract by liquid chromatography-tandem mass spectrometry. , 2001, Journal of chromatography. A.

[5]  A. Angioni,et al.  Simplified multiresidue method for the determination of organophosphorus insecticides in olive oil , 1997 .

[6]  M. Scherbaum.  Multimethode zur Bestimmung von Pflanzenschutz- und Oberflächenbehandlungsmittel-Rückständen in Zitrusfrüchten mittels GC-MSD : Teil 1: Theoretische Grundlagen und Methodenentwicklung , 1997 .

[7]  P. Marriott,et al.  Concepts and Preliminary Observations on the Triple-Dimensional Analysis of Complex Volatile Samples by Using GC×GC−TOFMS , 2001 .

[8]  J. Hajšlová,et al.  Optimization and application of the PTV injector for the analysis of pesticide residues , 2001 .

[9]  H. Müller,et al.  Thermal degradation observed with different injection techniques: quantitative estimation by the use of thermolabile carbamate pesticides. , 1990 .

[10]  J. Hajšlová,et al.  Pulsed Splitless Injection and the Extent of Matrix Effects in the Analysis of Pesticides , 1999 .

[11]  D. Hercules,et al.  LC-MS/MS signal suppression effects in the analysis of pesticides in complex environmental matrices , 2001, Fresenius' journal of analytical chemistry.

[12]  Bernard K. Choi,et al.  Postcolumn Introduction of an Internal Standard for Quantitative LC−MS Analysis , 1999 .

[13]  S. Lehotay.  Analysis of pesticide residues in mixed fruit and vegetable extracts by direct sample introduction/gas chromatography/tandem mass spectrometry. , 2000, Journal of AOAC International.

[14]  Michael G. Ikonomou,et al.  Investigations of the electrospray interface for liquid chromatography/mass spectrometry , 1990 .

[15]  J. Seiber,et al.  Pesticide Residues in Foods: Methods, Techniques, and Regulations , 1999 .

[16]  L. Cuadros-Rodríguez,et al.  Matrix-effects of vegetable commodities in electron-capture detection applied to pesticide multiresidue analysis. , 2002, Journal of chromatography. A.

[17]  Jonathan Williams,et al.  Unravelling the composition of very complex samples by comprehensive gas chromatography coupled to time-of-flight mass spectrometry. Cigarette smoke. , 2002, Journal of chromatography. A.

[18]  J. Hajšlová,et al.  Matrix-induced effects: a critical point in the gas chromatographic analysis of pesticide residues , 1998 .

[19]  J. Foley,et al.  Reduction in matrix-related signal suppression effects in electrospray ionization mass spectrometry using on-line two-dimensional liquid chromatography. , 2001, Analytical chemistry.

[20]  J. Hajšlová,et al.  Performance of programmed temperature vaporizer, pulsed splitless and on-column injection techniques in analysis of pesticide residues in plant matrices. , 2001, Journal of chromatography. A.

[21]  J. V. Sancho,et al.  Study of matrix effects on the direct trace analysis of acidic pesticides in water using various liquid chromatographic modes coupled to tandem mass spectrometric detection. , 2001, Journal of chromatography. A.

[22]  J. Smeraglia,et al.  Matrix effects and selectivity issues in LC-MS-MS , 2002 .

[23]  H. Müller,et al.  Evaluation of automated and manual hot-splitless, cold-splitless (PTV), and on-column injection technique using capillary gas chromatography for the analysis of organophosphorus pesticides , 1988 .

[24]  C. Poole,et al.  A study of single compound additives to minimize the matrix induced chromatographic response enhancement observed in the gas chromatography of pesticide residues , 1993 .

[25]  D L Buhrman,et al.  Quantitation of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry: A study of ion suppression , 1996, Journal of the American Society for Mass Spectrometry.

[26]  B. Matuszewski,et al.  Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations. , 1998, Analytical chemistry.

[27]  J. Hajšlová,et al.  Alternative calibration approaches to compensate the effect of co-extracted matrix components in liquid chromatography-electrospray ionisation tandem mass spectrometry analysis of pesticide residues in plant materials. , 2002, Journal of chromatography. A.

[28]  J. Startin,et al.  High‐performance Liquid Chromatography/Atmospheric Pressure Chemical Ionization Mass Spectrometry with Ionization Polarity Switching for the Determination of Selected Pesticides , 1997 .

[29]  P. Kebarle,et al.  From ions in solution to ions in the gas phase - the mechanism of electrospray mass spectrometry , 1993 .

[30]  S. Lehotay,et al.  Does further clean-up reduce the matrix enhancement effect in gas chromatographic analysis of pesticide residues in food? , 2000, Journal of chromatography. A.

[31]  John B. Phillips,et al.  Comprehensive Two-Dimensional Gas Chromatography using an On-Column Thermal Modulator Interface , 1991 .

[32]  C. Poole,et al.  Matrix‐induced peak enhancement of pesticides in gas chromatogrtaphy: Is there a solution? , 1997 .

[33]  W. Bertsch,et al.  Two‐Dimensional Gas Chromatography. Concepts, Instrumentation, and Applications – Part 2: Comprehensive Two‐Dimensional Gas Chromatography , 2000 .

[34]  S. Dagan,et al.  A Direct Sample Introduction Device for Mass Spectrometry Studies and Gas Chromatography Mass Spectrometry Analyses , 1997 .

[35]  J. Bernal,et al.  Matrix effects in the determination of acaricides and fungicides in must by gas chromatography with electron-capture and nitrogen-phosphorus detection , 1997 .

[36]  R. K. Juhler,et al.  Analysis of Chlormequat residues in grain using liquid chromatography-mass spectrometry (LC-MS/MS) , 1998 .

[37]  W. Bertsch,et al.  Two‐Dimensional Gas Chromatography. Concepts, Instrumentation, and Applications – Part 1: Fundamentals, Conventional Two‐Dimensional Gas Chromatography, Selected Applications , 1999 .

[38]  Bruce W. Hermann,et al.  Using electronic pressure programming to reduce the decomposition of labile compounds during splitless injection , 1992 .

[39]  A. M. Gillespie,et al.  Explanation of the matrix-induced chromatographic response enhancement of organophosphorus pesticides during open tubular column gas chromatography with splitless or hot on-column injection and flame photometric detection , 1993 .

[40]  J. Hajšlová,et al.  Stability of pesticides in plant extracts used as calibrants in the gas chromatographic analysis of residues , 1998 .

[41]  J. V. Iribarne,et al.  Field induced ion evaporation from liquid surfaces at atmospheric pressure , 1979 .

[42]  A. G. Frenich,et al.  Correction function on biased results due to matrix effects Application to the routine analysis of pesticide residues , 2003 .

[43]  U. Brinkman,et al.  Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometric detection applied to the determination of pesticides in food extracts. , 2002, Journal of chromatography. A.