Knockdown of TNF-α by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction.

[1]  G. Schreiner,et al.  Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[2]  H. Fillit,et al.  Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. , 1990, The New England journal of medicine.

[3]  Simon C Watkins,et al.  Negative inotropic effects of cytokines on the heart mediated by nitric oxide. , 1992, Science.

[4]  F. Pagani,et al.  Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-alpha in conscious dogs. , 1992, The Journal of clinical investigation.

[5]  L. Vaca,et al.  Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart. , 1993, The Journal of clinical investigation.

[6]  J. Parrillo,et al.  Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum , 1996, The Journal of experimental medicine.

[7]  M. Yacoub,et al.  Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy , 1996, The Lancet.

[8]  A. Matsumori,et al.  Cytokine gene expression after myocardial infarction in rat hearts: possible implication in left ventricular remodeling. , 1998, Circulation.

[9]  F. Clubb,et al.  Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats. , 1998, Circulation.

[10]  Georg Ertl,et al.  Tumor Necrosis Factor- α at Acute Myocardial Infarction in Rats andÈEffects on Cardiac Fibroblasts☆ , 1999 .

[11]  D. Mann,et al.  Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium. , 1999, Circulation.

[12]  Xiangru Lu,et al.  Tumor necrosis factor-α induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes , 2000 .

[13]  G Baumgarten,et al.  Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[14]  D. Mann,et al.  Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor , 2001, Circulation.

[15]  P. Iversen,et al.  DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure. , 2001, American journal of physiology. Heart and circulatory physiology.

[16]  S. Anker,et al.  How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH. , 2002, International journal of cardiology.

[17]  M. Sack Tumor necrosis factor-alpha in cardiovascular biology and the potential role for anti-tumor necrosis factor-alpha therapy in heart disease. , 2002, Pharmacology & therapeutics.

[18]  M. Sack Tumor necrosis factor-α in cardiovascular biology and the potential role for anti-tumor necrosis factor-α therapy in heart disease , 2002 .

[19]  M. Entman,et al.  The inflammatory response in myocardial infarction. , 2002, Cardiovascular research.

[20]  S. Stass,et al.  Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. , 2002, Cancer research.

[21]  D. Kereiakes Adjunctive Pharmacotherapy before Percutaneous Coronary Intervention in Non-ST-Elevation Acute Coronary Syndromes: The Role of Modulating Inflammation , 2003, Circulation.

[22]  J. Marín-García,et al.  In vivo TNF-α inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure , 2004 .

[23]  N. Khaper,et al.  Inflammatory cytokines and postmyocardial infarction remodeling. , 2004, Circulation research.

[24]  J. Marín-García,et al.  In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure. , 2004, American journal of physiology. Heart and circulatory physiology.

[25]  E. Camenzind,et al.  Inflammatory response post-myocardial infarction and reperfusion: a new therapeutic target? , 2005 .

[26]  G. Xiang,et al.  Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction. , 2005, Journal of the American College of Cardiology.

[27]  Shubiao Zhang,et al.  Toxicity of cationic lipids and cationic polymers in gene delivery. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[28]  Chad A. Mirkin,et al.  Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation , 2006, Science.

[29]  A. Zima,et al.  Redox regulation of cardiac calcium channels and transporters. , 2006, Cardiovascular research.

[30]  Chad A Mirkin,et al.  Maximizing DNA loading on a range of gold nanoparticle sizes. , 2006, Analytical chemistry.

[31]  Chad A Mirkin,et al.  The bio-barcode assay for the detection of protein and nucleic acid targets using DTT-induced ligand exchange , 2006, Nature Protocols.

[32]  L. Khachigian,et al.  DNAzymes targeting the transcription factor Egr‐1 reduce myocardial infarct size following ischemia–reperfusion in rats , 2006, Journal of thrombosis and haemostasis : JTH.

[33]  N. Frangogiannis Targeting the inflammatory response in healing myocardial infarcts. , 2006, Current medicinal chemistry.

[34]  C. Mirkin,et al.  Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. , 2007, Nano letters.

[35]  P. Libby,et al.  The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions , 2007, The Journal of experimental medicine.

[36]  Nobel C. Zong,et al.  Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection. , 2008, Journal of molecular and cellular cardiology.

[37]  Samir Mitragotri,et al.  Role of Particle Size in Phagocytosis of Polymeric Microspheres , 2008, Pharmaceutical Research.

[38]  P. Libby,et al.  Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites , 2009, Science.

[39]  L. Khachigian,et al.  c-Jun DNAzymes Inhibit Myocardial Inflammation, ROS Generation, Infarct Size, and Improve Cardiac Function After Ischemia-Reperfusion Injury , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[40]  S. Kostin,et al.  Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction , 2009, Journal of cellular and molecular medicine.

[41]  G. Heusch,et al.  TNFα in myocardial ischemia/reperfusion, remodeling and heart failure , 2010, Heart Failure Reviews.

[42]  G. Hannon,et al.  Small RNA sorting: matchmaking for Argonautes , 2011, Nature Reviews Genetics.

[43]  A. Zarbock,et al.  Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing , 2012, Journal of Molecular Medicine.

[44]  M. Sargianou,et al.  Interleukin-12 (IL-12)/IL-10 Ratio as a Marker of Disease Severity in Crimean-Congo Hemorrhagic Fever , 2012, Clinical and Vaccine Immunology.

[45]  C. Mirkin,et al.  Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation , 2012, Proceedings of the National Academy of Sciences.

[46]  Chad A Mirkin,et al.  Spherical nucleic acids. , 2012, Journal of the American Chemical Society.

[47]  Kevin Yehl,et al.  Catalytic deoxyribozyme-modified nanoparticles for RNAi-independent gene regulation. , 2012, ACS nano.

[48]  Chad A Mirkin,et al.  Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates , 2013, Proceedings of the National Academy of Sciences.

[49]  Chad A. Mirkin,et al.  Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma , 2013, Science Translational Medicine.

[50]  Sarah Seifert,et al.  Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape , 2013, Nature Biotechnology.

[51]  Xiangjian Luo,et al.  Targeting EBV-LMP1 DNAzyme enhances radiosensitivity of nasopharyngeal carcinoma cells by inhibiting telomerase activity , 2014, Cancer biology & therapy.

[52]  A. Zima,et al.  Regulation of sarcoplasmic reticulum Ca(2+) release by cytosolic glutathione in rabbit ventricular myocytes. , 2014, Free radical biology & medicine.

[53]  Chad A. Mirkin,et al.  Intracellular Fate of Spherical Nucleic Acid Nanoparticle Conjugates , 2014, Journal of the American Chemical Society.

[54]  D. Mozaffarian,et al.  Heart disease and stroke statistics--2014 update: a report from the American Heart Association. , 2014, Circulation.

[55]  Conor J. Walsh,et al.  Drug and cell delivery for cardiac regeneration. , 2015, Advanced drug delivery reviews.

[56]  N. Krug,et al.  Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma. , 2015, The Journal of allergy and clinical immunology.

[57]  C. Bachert,et al.  Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. , 2015, The New England journal of medicine.

[58]  Mark D. Huffman,et al.  AHA Statistical Update Heart Disease and Stroke Statistics — 2012 Update A Report From the American Heart Association WRITING GROUP MEMBERS , 2010 .