In this study, the performance of Sub-Saharan African railways systems (SSA) is assessed by using an integrated Entropy-MARCOS (Measurement Alternatives and Ranking according to COmpromise Solution) - based methodology. In the first phase, the Entropy method is employed to determine the weights of each sub-criterion of the decision model. This process identifies six main criteria, i.e., safety, security, internal business aspect, intermodal aspect, innovation, and learning aspect, and customer satisfaction which are further supplemented by 13 sub-criteria. In the second phase, the MARCOS method is used to rank the countries based on their railway performance assessment. Based on the results from the proposed method, a sensitivity analysis was carried out through a comparative analysis with seven other multi-criteria decision-making (MCDM) methods. The results of the study indicate that the most weighted sub-criterion is the labor productivity (internal business perspective criteria) followed by the terrorist incidence (security criteria) and the number of employees going through training/exposure sessions (innovation and learning perspective criteria). Moreover, it was revealed that Kenya is the best alternative in terms of its railway performance followed by Ethiopia, Cameroon, Nigeria, and Ghana. Based on the findings from this study, decision-makers can be assisted during the operative, designing, and planning investigations of the railway system through the consideration of these parameters as insert indicators. Also, the findings can help as a benchmark for the performance analysis of other railway systems in other African countries.