PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro

The ∼14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large (∼460 kDa) protein, termed polycystin‐1 (PC‐1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig‐like domains/PKD domains) suggests that it may play an important role in cell–cell/cell–matrix interactions. Here we demonstrated that PKD1 promoted cell–cell and cell–matrix interactions in cancer cells, indicating that PC‐1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC‐1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes Copyright © 2007 John Wiley & Sons, Ltd.

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