Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

[1]  M. Mattson,et al.  Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury , 1994, Experimental Neurology.

[2]  V. Herzog,et al.  Binding and Selective Detection of the Secretory N-terminal Domain of the Alzheimer Amyloid Precursor Protein on Cell Surfaces , 1999, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[3]  S. Barger,et al.  Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E , 1997, Nature.

[4]  K. Beyreuther,et al.  Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein , 1997, Nature Medicine.

[5]  C. Masters,et al.  Expression and analysis of heparin‐binding regions of the amyloid precursor protein of Alzheimer's disease , 1997, FEBS letters.

[6]  J. O’Connor,et al.  SB203580, the p38 mitogen-activated protein kinase inhibitor blocks the inhibitory effect of β-amyloid on long-term potentiation in the rat hippocampus , 2000, Neuroscience Letters.

[7]  D. Selkoe,et al.  Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Y. Bailly,et al.  Synaptic β-amyloid precursor proteins increase with learning capacity in rats , 1997, Neuroscience.

[9]  T. Arendt.  Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease , 2001, International Journal of Developmental Neuroscience.

[10]  J. Kimura,et al.  Ultrastructural localization of amyloid protein precursor in the normal and postischemic gerbil brain , 1995, Brain Research.

[11]  D. Selkoe,et al.  The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner* , 2001, The Journal of Biological Chemistry.

[12]  O. Vitolo,et al.  Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[13]  V. Bigl,et al.  Ontogenetic changes in protein level of amyloid precursor protein (APP) in growth cones and synaptosomes from rat brain and prenatal expression pattern of APP mRNA isoforms in developing rat embryo , 2001, International Journal of Developmental Neuroscience.

[14]  C. Regan,et al.  Intraventricular infusions of antibodies to amyloid-β-protein precursor impair the acquisition of a passive avoidance response in the rat , 1990, Neuroscience Letters.

[15]  B. Strooper,et al.  γ-Secretase: never more enigmatic , 2001, Trends in Neurosciences.

[16]  M. Mattson,et al.  Secreted form of β‐amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices , 1997, Neuroreport.

[17]  J. Growdon,et al.  Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[18]  W. K. Cullen,et al.  Block of LTP in rat hippocampus in vivo by β‐amyloid precursor protein fragments , 1997 .

[19]  N. Hooper,et al.  Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase. , 1998, Biochemistry.

[20]  D. Allsop,et al.  The isolation and amino acid composition of senile plaque core protein , 1983, Brain Research.

[21]  J. Lancaster,et al.  Activation of Tumor Necrosis Factor-α-converting Enzyme-mediated Ectodomain Shedding by Nitric Oxide* , 2000, The Journal of Biological Chemistry.

[22]  S. Younkin,et al.  Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition , 2001, Neurobiology of Aging.

[23]  R. Wurtman,et al.  Environmental conditions influence hippocampus‐dependent behaviours and brain levels of amyloid precursor protein in rats , 2002, The European journal of neuroscience.

[24]  J. Hardy,et al.  Amyloid deposition as the central event in the aetiology of Alzheimer's disease. , 1991, Trends in pharmacological sciences.

[25]  T. Nabeshima,et al.  Impairments of long-term potentiation in hippocampal slices of beta-amyloid-infused rats. , 1999, European journal of pharmacology.

[26]  A. Kimura,et al.  Tip60 acetylates six lysines of a specific class in core histones in vitro , 1998, Genes to cells : devoted to molecular & cellular mechanisms.

[27]  P. Rowell,et al.  Nicotinic Stimulation of [3H]Acetylcholine Release from Mouse Cerebral Cortical Synaptosomes , 1984, Journal of neurochemistry.

[28]  G. Dawson,et al.  β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity , 1995, Cell.

[29]  J. David Sweatt,et al.  β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:In Vitro and In Vivo Mechanisms Related to Alzheimer's Disease , 2001, The Journal of Neuroscience.

[30]  S. Takeda,et al.  Ligand-dependent G Protein Coupling Function of Amyloid Transmembrane Precursor (*) , 1995, The Journal of Biological Chemistry.

[31]  J. Yakel,et al.  β-Amyloid1–42 Peptide Directly Modulates Nicotinic Receptors in the Rat Hippocampal Slice , 2001, The Journal of Neuroscience.

[32]  B. Hyman,et al.  Demonstration by Fluorescence Resonance Energy Transfer of Two Sites of Interaction between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein: Role of the Intracellular Adapter Protein Fe65 , 2001, The Journal of Neuroscience.

[33]  C. Masters,et al.  Amyloid precursor protein of Alzheimer's disease: evidence for a stable, full‐length, trans‐membrane pool in primary neuronal cultures , 1999, The European journal of neuroscience.

[34]  B. Margolis,et al.  The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein , 1996, Molecular and cellular biology.

[35]  R. Anwyl,et al.  beta-Amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus. , 1995, Neuroreport.

[36]  N. Seidah,et al.  Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides 1 Published on the World Wide Web on 17 August 1999. 1 , 1999, Brain Research.

[37]  J. Rommens,et al.  Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. , 1996, Human molecular genetics.

[38]  G. Perry,et al.  Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[39]  S. Wagner,et al.  Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits , 1999, Neuroscience.

[40]  Gary Lynch,et al.  Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice , 1999, Brain Research.

[41]  S. Davis,et al.  Generation of Aggregated β-Amyloid in the Rat Hippocampus Impairs Synaptic Transmission and Plasticity and Causes Memory Deficits , 2001, The Journal of Neuroscience.

[42]  C. Herron,et al.  Blockade of long-term potentiation by beta-amyloid peptides in the CA1 region of the rat hippocampus in vivo. , 2001, Journal of neurophysiology.

[43]  W. Singer,et al.  Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation , 1993, Trends in Neurosciences.

[44]  Brett Chromy,et al.  Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus , 2002, Brain Research.

[45]  V. Bigl,et al.  Constitutive overactivation of protein kinase C in guinea pig brain increases α‐secretory APP processing without decreasing β‐amyloid generation , 2000 .

[46]  L. Lue,et al.  Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer’s Disease , 1999 .

[47]  M. Mattson,et al.  Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor , 1996 .

[48]  G. Wilcock,et al.  alpha- and beta-secretase: profound changes in Alzheimer's disease. , 2002, Biochemical and biophysical research communications.

[49]  Y. Ihara,et al.  Alzheimer's disease: β‐Amyloid protein and tau , 2002, Journal of neuroscience research.

[50]  M. Adams,et al.  Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease , 1996, Neuroreport.

[51]  R. Neve,et al.  The Amyloid Precursor Protein-binding Protein APP-BP1 Drives the Cell Cycle through the S-M Checkpoint and Causes Apoptosis in Neurons* , 2000, The Journal of Biological Chemistry.

[52]  H. Vanderstichele,et al.  The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein , 2001, The Journal of cell biology.

[53]  S. Henriksen,et al.  In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice , 2000, Brain Research.

[54]  V. Katta,et al.  Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties. , 2000 .

[55]  S. Younkin,et al.  Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice , 1996, Science.

[56]  P. Mcgeer,et al.  Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons , 1992, Brain Research.

[57]  N. Smalheiser,et al.  Evidence for binding of the ectodomain of amyloid precursor protein 695 and activated high molecular weight kininogen. , 2002, Biochimica et biophysica acta.

[58]  T. Katada,et al.  Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease. , 1996, The EMBO journal.

[59]  D. Selkoe,et al.  Amyloid β-peptide is produced by cultured cells during normal metabolism , 1992, Nature.

[60]  D. Small,et al.  Regulation of APP cleavage by α‐, β‐ and γ‐secretases , 2000 .

[61]  P. Greengard,et al.  The Alzheimer Amyloid Precursor Protein (APP) and Fe65, an APP-Binding Protein, Regulate Cell Movement , 2001, The Journal of cell biology.

[62]  M. Mattson.  Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. , 1997, Physiological reviews.

[63]  Ralph A. Nixon,et al.  Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease , 2000, Nature.

[64]  V. Bigl,et al.  Glutamate-stimulated secretion of amyloid precursor protein from cortical rat brain slices , 1997, Neurochemistry International.

[65]  W. März,et al.  Apolipoprotein E and beta A4-amyloid: signals and effects. , 2001, Biochemical Society symposium.

[66]  S. Shiojiri,et al.  Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity , 1988, Nature.

[67]  J. Oka,et al.  Endogenous GLP-1 is involved in β-amyloid protein-induced memory impairment and hippocampal neuronal death in rats , 2000, Brain Research.

[68]  K. Kawasaki,et al.  Amyloid β Protein Potentiates Ca2+ Influx Through L‐Type Voltage‐Sensitive Ca2+ Channels: A Possible Involvement of Free Radicals , 1997, Journal of neurochemistry.

[69]  G. Collingridge,et al.  Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein , 2001, The Journal of Neuroscience.

[70]  J. Kimura,et al.  Tissue-specific expression of three types of β-protein precursor mRNA: Enhancement of protease inhibitor-harboring types in Alzheimer's disease brain , 1989 .

[71]  N. Robakis,et al.  Intracellular Cyclic AMP Inhibits Constitutive and Phorbol Ester‐Stimulated Secretory Cleavage of Amyloid Precursor Protein , 1996, Journal of neurochemistry.

[72]  Michael J. Rowan,et al.  Amyloid-β oligomers: their production, toxicity and therapeutic inhibition , 2001 .

[73]  J. Morley,et al.  An amyloid β-protein fragment, Aβ[12–28], equipotently impairs post-training memory processing when injected into different limbic system structures , 1994, Brain Research.

[74]  M. Mclaughlin,et al.  Protein Kinase C Activation Potentiates the Rapid Secretion of the Amyloid Precursor Protein from Rat Cortical Synaptosomes , 1999, Journal of neurochemistry.

[75]  R. Neve,et al.  Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[76]  L. Mucke,et al.  Neurotrophic and Neuroprotective Effects of hAPP in Transgenic Mice a , 1996, Annals of the New York Academy of Sciences.

[77]  L. Ye,et al.  Suppressive action produced by β-amyloid peptide fragment 31–35 on long-term potentiation in rat hippocampus is N-methyl-d-aspartate receptor-independent: it's offset by (−)huperzine A , 1999, Neuroscience Letters.

[78]  C. Gray,et al.  Regulation of β-amyloid precursor protein isoform mRNAs by transforming growth factor-β1 and interleukin-1β in astrocytes , 1993 .

[79]  M. Wolfe,et al.  A Portrait of Alzheimer Secretases--New Features and Familiar Faces , 2001, Science.

[80]  M. Mesulam,et al.  A Plasticity‐Based Theory of the Pathogenesis of Alzheimer's Disease , 2000, Annals of the New York Academy of Sciences.

[81]  L. Amaducci,et al.  The Early Story of Alzheimer's Disease , 1987 .

[82]  H. Cai,et al.  BACE1 is the major β-secretase for generation of Aβ peptides by neurons , 2001, Nature Neuroscience.

[83]  P. Pelicci,et al.  Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc* , 2002, The Journal of Biological Chemistry.

[84]  K. Duff,et al.  Behavioral Changes in Transgenic Mice Expressing Both Amyloid Precursor Protein and Presenilin-1 Mutations: Lack of Association with Amyloid Deposits , 1999, Behavior genetics.

[85]  Y Miyashita,et al.  Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito‐temporo‐hippocampal pathway in adult macaque monkeys , 1999, The Journal of comparative neurology.

[86]  H. Okamoto,et al.  Tissue-Specific expression of rat kininogen mRNAs. , 2000, Biological & pharmaceutical bulletin.

[87]  D. Selkoe,et al.  Normal and abnormal biology of the beta-amyloid precursor protein. , 1994, Annual review of neuroscience.

[88]  R. Doms,et al.  Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme , 2000, The Journal of Biological Chemistry.

[89]  D. Borchelt,et al.  Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo , 1996, Neuron.

[90]  F. Fahrenholz,et al.  Regulation of the α‐secretase ADAM10 by its prodomain and proprotein convertases , 2001 .

[91]  A. Delacourte,et al.  Electrophysiological effects of 25–35 amyloid-β-protein on guinea-pig lateral septal neurons , 1993, Neuroscience Letters.

[92]  M. Mattson,et al.  Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein , 1993, Neuron.

[93]  Thomas C. Südhof,et al.  A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60 , 2001, Science.

[94]  S. Frantz,et al.  Set back to Alzheimer vaccine studies , 2002, Nature Medicine.

[95]  D. Selkoe,et al.  Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[96]  W. Strittmatter.  Apolipoprotein E and Alzheimer's disease: signal transduction mechanisms. , 2001, Biochemical Society symposium.

[97]  W. K. Cullen,et al.  Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.

[98]  R. Hawkins,et al.  Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus. , 1998, Progress in brain research.

[99]  H. Lipp,et al.  Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members , 2000, The Journal of Neuroscience.

[100]  A. Prochiantz,et al.  The Amyloid Precursor Protein Interacts with Go Heterotrimeric Protein within a Cell Compartment Specialized in Signal Transduction , 1999, The Journal of Neuroscience.

[101]  Takurou Kobayashi,et al.  The mutation in amyloid precursor protein inhibits both α- and β-secretion , 1995, Neuroscience Letters.

[102]  M. Cruts,et al.  Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3. , 1995, Human molecular genetics.

[103]  R. Mileusnic,et al.  APP is required during an early phase of memory formation , 2000, The European journal of neuroscience.

[104]  G. Schneider,et al.  The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis. , 1994, Developmental biology.

[105]  Raphael Kopan,et al.  Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain , 1998, Nature.

[106]  C. Finch,et al.  Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum? , 2001, Trends in Neurosciences.

[107]  B. Strooper,et al.  Proteolytic processing and cell biological functions of the amyloid precursor protein. , 2000, Journal of cell science.

[108]  I. Kola,et al.  BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. , 2001, Human molecular genetics.

[109]  K. Suzuki,et al.  Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. , 1999, The Biochemical journal.

[110]  R. Roncarati,et al.  Jun NH2-terminal Kinase (JNK) Interacting Protein 1 (JIP1) Binds the Cytoplasmic Domain of the Alzheimer's β-Amyloid Precursor Protein (APP)* , 2002, The Journal of Biological Chemistry.

[111]  N. Robakis,et al.  Alzheimer's disease: a re-examination of the amyloid hypothesis , 1998, Trends in Neurosciences.

[112]  P. A. Peterson,et al.  β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity , 2000, The Journal of Biological Chemistry.

[113]  G. K. Wilcock,et al.  Plaques, tangles and dementia A quantitative study , 1982, Journal of the Neurological Sciences.

[114]  B. Hyman,et al.  LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation , 1995, Cell.

[115]  M. Lambert,et al.  Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α , 1997, Nature.

[116]  P. Rakic,et al.  Requirement of the JIP1 scaffold protein for stress-induced JNK activation. , 2001, Genes & development.

[117]  T. Holzman,et al.  Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths. , 1994, Biophysical journal.

[118]  L. Wahlund,et al.  Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation. , 1997, Archives of neurology.

[119]  F. Acquati,et al.  The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region , 2000, FEBS letters.

[120]  C. Schnitzler,et al.  BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein , 2000 .

[121]  F. Checler,et al.  Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts , 2001, Nature Cell Biology.

[122]  T. Shimahara,et al.  Alzheimer Amyloid β-Peptide Inhibits the Late Phase of Long-Term Potentiation through Calcineurin-Dependent Mechanisms in the Hippocampal Dentate Gyrus , 2002, Neurobiology of Learning and Memory.

[123]  R. Nicoll,et al.  Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[124]  B. Carter,et al.  Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[125]  C. Blobel,et al.  Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE). , 2000, The Biochemical journal.

[126]  A. Matsumoto,et al.  A novel carboxypeptidase B that processes native β‐amyloid precursor protein is present in human hippocampus , 2000, The European journal of neuroscience.

[127]  J. Morley,et al.  β-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory , 2000, Peptides.

[128]  W. Ma,et al.  Amyloid β peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures , 2002, Neuroscience.

[129]  Bradley T. Hyman,et al.  The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. , 2002, The Journal of biological chemistry.

[130]  Nicole Nelson,et al.  A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells , 1997, Nature.

[131]  J. Moreau,et al.  Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach , 1993, Brain Research.

[132]  C. Glabe,et al.  Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP) , 1996, Brain Research.

[133]  P. Reiner,et al.  Mitogen-activated protein kinase is involved in N-methyl-d-aspartate receptor regulation of amyloid precursor protein cleavage , 1999, Neuroscience.

[134]  G. Forloni.  Neurotoxicity of beta-amyloid and prion peptides. , 1996, Current Opinion in Neurology.

[135]  George A. Carlson,et al.  The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease , 2002, The Journal of Neuroscience.

[136]  U. Hansen,et al.  One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs , 1994, Molecular and cellular biology.

[137]  R. Cowburn,et al.  Effects of β-Amyloid-(25-35) Peptides on Radioligand Binding to Excitatory Amino Acid Receptors and Voltage-Dependent Calcium Channels: Evidence for a Selective Affinity for the Glutamate and Glycine Recognition Sites of the NMDA Receptor , 1997, Neurochemical Research.

[138]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[139]  L. Helmuth.  New Alzheimer's Treatments That May Ease the Mind , 2002, Science.

[140]  R. Neve,et al.  beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[141]  T. Russo,et al.  The Fe65 Adaptor Protein Interacts through Its PID1 Domain with the Transcription Factor CP2/LSF/LBP1* , 1998, The Journal of Biological Chemistry.

[142]  R. Wetzel,et al.  Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide. , 1995, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[143]  D. Linden,et al.  Synaptic Transmission and Hippocampal Long-Term Potentiation in Transgenic Mice Expressing FAD-Linked Presenilin 1 , 1999, Neurobiology of Disease.

[144]  W. K. Cullen,et al.  β‐Amyloid produces a delayed NMDA receptor‐ dependent reduction in synaptic transmission in rat hippocampus , 1996, Neuroreport.

[145]  B. Winblad,et al.  Levels of α- and β-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients , 2000, Neuroscience Letters.

[146]  U. Hansen,et al.  Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. , 2002, The Journal of biological chemistry.

[147]  J. Rossant,et al.  Notch1 is required for the coordinate segmentation of somites. , 1995, Development.

[148]  D. Ji,et al.  Timing and Location of Nicotinic Activity Enhances or Depresses Hippocampal Synaptic Plasticity , 2001, Neuron.

[149]  L. Goldstein,et al.  Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP , 2001, Nature.

[150]  B. Kagan,et al.  Impairment of hippocampal long‐term potentiation by Alzheimer amyloid β‐peptides , 2000 .

[151]  Y. Allen,et al.  Nicotine and its interaction with β-amyloid protein: a short review , 2001, Biological Psychiatry.

[152]  F. Tang,et al.  The effect of age on the response of the rat brains to continuous β-amyloid infusion , 2001, Brain Research.

[153]  C. Masters,et al.  Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I (*) , 1996, The Journal of Biological Chemistry.

[154]  A Cumano,et al.  A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. , 2000, Molecular cell.

[155]  T. Mizuno,et al.  Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains. , 2000, Biochimica et biophysica acta.

[156]  J. Korenberg,et al.  APP-BP1, a Novel Protein That Binds to the Carboxyl-terminal Region of the Amyloid Precursor Protein (*) , 1996, The Journal of Biological Chemistry.

[157]  S. Younkin.  Evidence that Aβ42 is the real culprit in alzheimer's disease , 1995 .

[158]  R. Quirion,et al.  Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[159]  J. Morley,et al.  Antibody to Amyloid β Protein Alleviates Impaired Acquisition, Retention, and Memory Processing in SAMP8 Mice , 2002, Neurobiology of Learning and Memory.

[160]  J. Hardy,et al.  Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease , 2000, Nature.

[161]  William J. Ray,et al.  A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain , 1999, Nature.

[162]  M. Mattson,et al.  Activation of K+ channels and suppression of neuronal activity by secreted β-amyloid-precursor protein , 1996, Nature.

[163]  G. Schellenberg,et al.  Candidate gene for the chromosome 1 familial Alzheimer's disease locus , 1995, Science.

[164]  M. Luca,et al.  α-Secretase ADAM10 as Well as αAPPs Is Reduced in Platelets and CSF of Alzheimer Disease Patients , 2002, Molecular medicine.

[165]  S. Barger,et al.  Neuronal–Glial Interactions Mediated by Interleukin-1 Enhance Neuronal Acetylcholinesterase Activity and mRNA Expression , 2000, The Journal of Neuroscience.

[166]  B. Yankner,et al.  An antibody to β amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types , 1991, Neuroscience Letters.

[167]  Christina A. Wilson,et al.  Presenilins are not required for Aβ42 production in the early secretory pathway , 2002, Nature Neuroscience.

[168]  G. Multhaup,et al.  Maturation and Pro-peptide Cleavage of β-Secretase* , 2000, The Journal of Biological Chemistry.

[169]  B. de Strooper,et al.  The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. , 2002, Human molecular genetics.

[170]  A. Campbell.  β-amyloid: friend or foe , 2001 .

[171]  S. Barger,et al.  Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function , 2001, Journal of neurochemistry.

[172]  Ruedi Aebersold,et al.  Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing , 2000, Nature.

[173]  R. Tanzi,et al.  Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). , 1994, The Journal of biological chemistry.

[174]  C. Masters,et al.  Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components , 1996, Brain Research.

[175]  Hugo Vanderstichele,et al.  Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein , 1998, Nature.

[176]  P. Lansbury,et al.  The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. , 1993, Biochemistry.

[177]  C. M. Whelan,et al.  Direct visualization of the gamma secretase‐generated carboxyl‐terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus , 2002, Journal of neurochemistry.

[178]  Hoau Yan Wang,et al.  Amyloid Peptide Aβ1‐42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors , 2000 .

[179]  W. Richards,et al.  Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation , 2001, Nature Neuroscience.

[180]  H. Meziane,et al.  Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[181]  D. Selkoe,et al.  Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity , 1999, Nature.

[182]  R. Neve,et al.  Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein. , 1999, Brain research. Molecular brain research.

[183]  B. Hyman,et al.  Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells , 1996, Nature Medicine.

[184]  J. Morley,et al.  Topography of a binding site for small amnestic peptides deduced from structure-activity studies: relation to amnestic effect of amyloid beta protein. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[185]  T. Bliss,et al.  Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice , 1999, Nature Neuroscience.

[186]  A. Artola,et al.  Synaptic Activity Modulates the Induction of Bidirectional Synaptic Changes in Adult Mouse Hippocampus , 2000, The Journal of Neuroscience.

[187]  M. Citron,et al.  Expression Analysis of BACE2 in Brain and Peripheral Tissues* , 2000, The Journal of Biological Chemistry.

[188]  X. Chen,et al.  RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease , 1996, Nature.

[189]  Albert-László Barabási,et al.  Error and attack tolerance of complex networks , 2000, Nature.

[190]  L. Lim,et al.  Characterization of the molecularly cloned murine alpha-globin transcription factor CP2. , 1993, The Journal of biological chemistry.

[191]  R. Iyengar,et al.  Goprotein as signal transducer in the pertussis toxin-sensitive phosphatidylinositol pathway , 1990, Nature.

[192]  E. Bienenstock,et al.  Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[193]  T. Morgan,et al.  Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[194]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[195]  Huaxi Xu,et al.  Presenilin 1 Is Required for Maturation and Cell Surface Accumulation of Nicastrin* , 2002, The Journal of Biological Chemistry.

[196]  J. Lancaster,et al.  Reactive oxygen species mediate tumor necrosis factor alpha‐converting, enzyme‐dependent ectodomain shedding induced by phorbol myristate acetate , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[197]  S. Davis,et al.  The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate Gyrus In Vivo , 2000, The Journal of Neuroscience.

[198]  D. Selkoe,et al.  Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments , 1992, Nature.

[199]  J. Jhamandas,et al.  Cellular mechanisms for amyloid beta-protein activation of rat cholinergic basal forebrain neurons. , 2001, Journal of neurophysiology.

[200]  J. Morley,et al.  Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[201]  M. Mattson,et al.  Secreted amyloid precursor protein α selectively suppresses N-methyl-d-aspartate currents in hippocampal neurons: involvement of cyclic GMP , 1998, Neuroscience.

[202]  K. Furukawa.  Signaling by β-Amyloid Precursor Protein , 1998 .

[203]  S. Turner,et al.  Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695* , 2001, The Journal of Biological Chemistry.

[204]  D. Alkon,et al.  Impairment of Hippocampal CA1 Heterosynaptic Transformation and Spatial Memory by β-Amyloid25–35 , 2002 .

[205]  L. Iversen,et al.  The toxicity in vitro of beta-amyloid protein. , 1995, The Biochemical journal.

[206]  N. Seidah,et al.  Constitutive α‐secretase cleavage of the β‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disintegrin metalloprotease ADAM10 , 2001, Journal of neurochemistry.

[207]  Alfredo G. Tomasselli,et al.  Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity , 1999, Nature.

[208]  K. Jellinger,et al.  [Alzheimer dementia. A clinical long-term study with quantitative neuropathology]. , 1991, Wiener Medizinische Wochenschrift.

[209]  R. Cowburn,et al.  Apolipoprotein E: a major piece in the Alzheimer's disease puzzle , 2001, Journal of cellular and molecular medicine.

[210]  E. Masliah,et al.  Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[211]  Hui Zheng,et al.  The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity , 1997, The Journal of Neuroscience.

[212]  K. Malik,et al.  Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration. , 1999, The Journal of biological chemistry.

[213]  J. Korf,et al.  Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice , 1997, Neuroreport.

[214]  G. Weskamp,et al.  Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity* , 1999, The Journal of Biological Chemistry.

[215]  M. Pákáski,et al.  Reversible and irreversible acetylcholinesterase inhibitors cause changes in neuronal amyloid precursor protein processing and protein kinase C level in vitro , 2001, Neurochemistry International.

[216]  R. Anwyl,et al.  Use-Dependent Effects of Amyloidogenic Fragments of β-Amyloid Precursor Protein on Synaptic Plasticity in Rat Hippocampus In Vivo , 2001, The Journal of Neuroscience.

[217]  D. Selkoe,et al.  The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. , 2000, Biochemistry.

[218]  W. Banks,et al.  Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice , 2000, Peptides.

[219]  I. Nishimoto,et al.  G protein βγ complex‐mediated apoptosis by familial Alzheimer's disease mutant of APP , 1997 .

[220]  D. Selkoe,et al.  Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. , 1999, The Journal of biological chemistry.

[221]  M. Mattson,et al.  Isoform‐Specific Modulation by Apolipoprotein E of the Activities of Secreted β‐Amyloid Precursor Protein , 1997, Journal of neurochemistry.

[222]  H. Lipp,et al.  No hippocampal neuron or synaptic bouton loss in learning-impaired aged β-Amyloid precursor protein-null mice , 1999, Neuroscience.

[223]  J. Treanor,et al.  Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. , 1999, Science.

[224]  A. Roses,et al.  CELLULAR LOCALIZATION OF MESSENGER RNA ENCODING AMYLOID‐BETA-PROTEIN IN NORMAL TISSUE AND IN ALZHEIMER DISEASE , 1988, Alzheimer disease and associated disorders.

[225]  C. L. Harris,et al.  Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing* , 1999, The Journal of Biological Chemistry.

[226]  S. Farber,et al.  Regulated secretion of beta-amyloid precursor protein in rat brain , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[227]  A. Smit,et al.  Synapse Formation between Central Neurons Requires Postsynaptic Expression of the MEN1 Tumor Suppressor Gene , 2001, The Journal of Neuroscience.

[228]  S. Sisodia.  Beta-amyloid precursor protein cleavage by a membrane-bound protease. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[229]  G. Buzsáki,et al.  Operational Dynamics in the Hippocampal-entorhinal Axis , 1998, Neuroscience & Biobehavioral Reviews.

[230]  D. Price,et al.  Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice , 1997, Neurobiology of Aging.

[231]  B. Anderton,et al.  Beta amyloid precursor protein mediates neuronal cell‐cell and cell‐surface adhesion , 1991, Journal of neuroscience research.

[232]  D. Small,et al.  Alzheimer's disease and Aβ toxicity: from top to bottom , 2001, Nature Reviews Neuroscience.

[233]  G. Forloni,et al.  Amyloid in alzheimer's disease and prion-related encephalopathies: Studies with synthetic peptides , 1996, Progress in Neurobiology.

[234]  S. Squazzo,et al.  Aggregation of Secreted Amyloid -Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture (*) , 1995, The Journal of Biological Chemistry.

[235]  P. Lansbury,et al.  Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. , 1997, Annual review of biochemistry.

[236]  Joseph D. Buxbaum,et al.  Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor* , 1998, The Journal of Biological Chemistry.

[237]  D. Selkoe,et al.  The Proteolytic Fragments of the Alzheimer’s Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex* , 1998, The Journal of Biological Chemistry.

[238]  R. E. Pitas,et al.  Secreted Forms of the Amyloid-β Precursor Protein Are Ligands for the Class A Scavenger Receptor* , 2001, The Journal of Biological Chemistry.

[239]  L. Mucke,et al.  Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice , 1994, Brain Research.

[240]  J. Buxbaum,et al.  Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path , 1998, The Journal of Neuroscience.

[241]  G. Schultz,et al.  The GTP-binding protein, Go9 regulates neuronal calcium channels , 1987, Nature.

[242]  B. Hyman,et al.  Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. , 2002, Archives of neurology.

[243]  G. Dawson,et al.  Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein , 1999, Neuroscience.

[244]  Walter Schubert,et al.  Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites , 1991, Brain Research.

[245]  Sebastian Pascarelle,et al.  Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68 , 2000, Nature.

[246]  Duane D. Miller,et al.  Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. , 1999, Biochemistry.

[247]  M. Mattson,et al.  Increased Activity‐Regulating and Neuroprotective Efficacy of α‐Secretase‐Derived Secreted Amyloid Precursor Protein Conferred by a C‐Terminal Heparin‐Binding Domain , 1996, Journal of neurochemistry.

[248]  N. Kowall,et al.  Hippocampal Injections of Amyloid β-Peptide 1-40 Impair Subsequent One-Trial/Day Reward Learning , 2001, Neurobiology of Learning and Memory.

[249]  B. Hyman,et al.  Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease , 2002, The Journal of Neuroscience.

[250]  J. Growdon,et al.  Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. , 1992, Science.

[251]  Guiquan Chen,et al.  A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease , 2000, Nature.

[252]  T. Bliss,et al.  Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats , 1994, Neuroscience Letters.

[253]  E. Klann,et al.  Long-Term Depression in the Adult Hippocampus In Vivo Involves Activation of Extracellular Signal-Regulated Kinase and Phosphorylation of Elk-1 , 2002, The Journal of Neuroscience.

[254]  M. H. Cobb,et al.  Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses , 2000, Nature Neuroscience.

[255]  E. Kojro,et al.  Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[256]  P. Greengard,et al.  Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[257]  D. Walsh,et al.  Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. , 1997, The Journal of biological chemistry.

[258]  Casey C. Lynch,et al.  Comprehensive Theory of Alzheimer's Disease: The Effects of Cholesterol on Membrane Receptor Trafficking , 2000, Annals of the New York Academy of Sciences.

[259]  Y. Suh,et al.  Memory impairment and cholinergic dysfunction by centrally administered Aβ and carboxyl‐terminal fragment of Alzheimer's APP in mice , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[260]  Joe Z Tsien,et al.  Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces , 2001, Neuron.

[261]  Y. Kirino,et al.  Phosphorylation-dependent Regulation of the Interaction of Amyloid Precursor Protein with Fe65 Affects the Production of β-Amyloid* , 2001, The Journal of Biological Chemistry.

[262]  N. Hooper,et al.  Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells. , 1999, Biochemistry.

[263]  R. Wurtman,et al.  Metabotropic Glutamate Receptor Subtype mGluR1α Stimulates the Secretion of the Amyloid β‐Protein Precursor Ectodomain , 1997 .

[264]  D. Selkoe,et al.  Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[265]  P. Greengard,et al.  Cell cycle‐dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. , 1994, The EMBO journal.

[266]  Ronald G. Thomas,et al.  Defective neurite extension is caused by a mutation in amyloid β/A4 (Aβ) protein precursor found in Familial Alzheimer's Disease , 1997 .

[267]  D. Holtzman,et al.  Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation , 2000, The Journal of Neuroscience.

[268]  M. Beal,et al.  The neurotoxicity of amyloid beta protein in aged primates. , 1998, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

[269]  F. Maxfield,et al.  Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor , 1996, Neuron.

[270]  B. Strooper,et al.  Interaction with Telencephalin and the Amyloid Precursor Protein Predicts a Ring Structure for Presenilins , 2001, Neuron.

[271]  R. Brookmeyer,et al.  A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease , 1997, Neurology.

[272]  N. Akaike,et al.  Amyloid β protein‐induced irreversible current in rat cortical neurones , 1994 .

[273]  L. Jen,et al.  Cell-specific expression of β-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes , 1997 .

[274]  C. Ponting,et al.  Identification of a novel family of presenilin homologues. , 2002, Human molecular genetics.

[275]  J. Hardy,et al.  Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP , 2001, Science.

[276]  G. Francis,et al.  Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae. , 2002, Journal of lipid research.

[277]  M. Shapiro,et al.  Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein , 1997, Nature.

[278]  D. Perlmutter,et al.  The Serpin-Enzyme Complex Receptor Recognizes Soluble, Nontoxic Amyloid-β Peptide but Not Aggregated, Cytotoxic Amyloid-β Peptide* , 1996, The Journal of Biological Chemistry.

[279]  W. Abraham,et al.  NMDA receptor regulation by amyloid-β does not account for its inhibition of LTP in rat hippocampus , 2003, Brain Research.

[280]  I. Nishimoto,et al.  Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go , 1993, Nature.

[281]  E. Kandel,et al.  APP Processing and Synaptic Plasticity in Presenilin-1 Conditional Knockout Mice , 2001, Neuron.

[282]  L. Wahlund,et al.  Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas , 1995, Nature Medicine.

[283]  S. Takeda,et al.  G Protein-Mediated Neuronal DNA Fragmentation Induced by Familial Alzheimer's Disease-Associated Mutants of APP , 1996, Science.

[284]  A. Koudinov,et al.  Essential role for cholesterol in synaptic plasticity and neuronal degeneration , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[285]  C. Masters,et al.  Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease , 1999, Annals of neurology.

[286]  T. Russo,et al.  Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's β‐amyloid precursor protein , 1998, FEBS letters.

[287]  C. Göritz,et al.  CNS synaptogenesis promoted by glia-derived cholesterol. , 2001, Science.

[288]  D. Strickland,et al.  LRP: a multifunctional scavenger and signaling receptor. , 2001, The Journal of clinical investigation.

[289]  W. Abraham,et al.  Glucocorticoid receptor activation lowers the threshold for NMDA-receptor-dependent homosynaptic long-term depression in the hippocampus through activation of voltage-dependent calcium channels. , 1997, Journal of neurophysiology.

[290]  G. Collingridge,et al.  Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein , 1999, Neuropharmacology.

[291]  M. Mesulam.  Neuroplasticity Failure in Alzheimer's Disease Bridging the Gap between Plaques and Tangles , 1999, Neuron.

[292]  M. Mattson,et al.  The secreted form of the Alzheimer's beta-amyloid precursor protein stimulates a membrane-associated guanylate cyclase. , 1995, The Biochemical journal.