Kidney preservation for transportation experimental analysis of optimal perfusate composition

Previous experiments have demonstrated that canine kidneys can be preserved for 24 hours or more following initial perfusion with a solution of intracellular composition (C3) and subsequent ice storage. In the present study the composition of C3 was varied to determine the role of each of the major constituents. The efficacy of the solution was found to depend more on magnesium sulphate than on the potassium content, although potassium assumed a greater importance in perfusates free of magnesium. No variation in composition produced a significant improvement in the results obtained with solution C3 itself.

[1]  G. Collins,et al.  KIDNEY PRESERVATION FOR TRANSPORTATION 6. A NEW PERFUSATE APPLIED TO HUMAN CADAVERIC KIDNEYS , 1971, The Medical journal of Australia.

[2]  G. Collins,et al.  KIDNEY PRESERVATION FOR TRANSPORTATION 5. COMPARISON OF PERFUSATES FOR HYPOTHERMIC STORAGE , 1971, The Medical journal of Australia.

[3]  K. E. Holley,et al.  Kidney preservation by initial perfusion and surface cooling. , 1971, The Journal of surgical research.

[4]  K. Calman,et al.  Solutions for organ preservation. , 1970, Lancet.

[5]  A. Sheil,et al.  Kidney preservation for transportation. IV. Eight-thousand-mile international air transport. , 1970, The Australian and New Zealand journal of surgery.

[6]  F O Belzer,et al.  Preservation and transplantation of human cadaver kidneys: a two-year experience. , 1970, Annals of surgery.

[7]  L. D. Stoddard,et al.  48-hour kidney storage. , 1970, Lancet.

[8]  J. Pena,et al.  The preservation of cadaveric kidneys for transplantation. , 1970, The British journal of surgery.

[9]  W. Webb,et al.  Preservation of the anoxic heart with a metabolic inhibitor and hypothermia. , 1970, Archives of surgery.

[10]  W. Smellie,et al.  Kidney preservation for transplantation. , 1970, Lancet.

[11]  A. Frost,et al.  Kidney preservation for transportation. , 1970, Lancet.

[12]  Paul I. Terasaki,et al.  KIDNEY PRESERVATION FOR TRANSPORTATION: II. A Simple Technique for 12‐hr Storage and Air Transport1 , 1969 .

[13]  G. Abouna.  Pig liver perfusion with human blood. The effect of preparing and flushing the liver with various balanced solutions on its subsequent viability and function , 1968, The British journal of surgery.

[14]  P. Uldall,et al.  THE PROBLEM OF RENAL PRESERVATION1 , 1966 .

[15]  J. S. Willis.  Characteristics of Ion Transport in Kidney Cortex of Mammalian Hibernators , 1966, The Journal of general physiology.

[16]  E. T. Pengelley,et al.  Changes in plasma magnesium concentration during hibernation in the golden-mantled ground squirrel (Citellus lateralis). , 1966, Comparative biochemistry and physiology.

[17]  F. Khalil,et al.  Hibernation in reptiles. I. Changes in blood electrolytes. , 1965, Comparative biochemistry and physiology.

[18]  R. Whittam,et al.  Vectorial aspects of adenosine-triphosphatase activity in erythrocyte membranes. , 1964, The Biochemical journal.

[19]  S. Kountz,et al.  Simple Kidney-storage Technique* , 1964, British medical journal.

[20]  M. N. Levy.  Oxygen consumption and blood flow in the hypothermic, perfused kidney. , 1959, The American journal of physiology.

[21]  R. Davies,et al.  Active transport of water, sodium, potassium and α-oxoglutarate by kidney-cortex slices , 1953 .