Characteristics of Effervescent Tablets of Lactobacilli Supplemented with Chinese Ginseng (Panax ginseng C.A. Meyer) and Polygonatum sibiricum

Development of probiotic products has always been popular in the food industry. Considering the advantages of effervescent tablets, developing probiotic products in effervescent tablet form was conducted in this study. Besides three Lactobacillus species, whole root powders of two medicine food homology herbs, Chinese ginseng (Panax ginseng C.A. Meyer) and Polygonatum sibiricum, were added to the formulation in equal amounts for multiple health care functions. Using the plate counting method, the viability of lactobacilli was measured. After tabletting, lactobacilli viability in tablets containing the two herbs, L-group (20 mg herbs/tablet), M-group (60 mg herbs/tablet), and H-group (100 mg herbs/tablet) was higher than that in the control (containing no herbs). After tablet disintegration, the survival rate of lactobacilli after gastrointestinal fluids treatment was measured; it was higher for the L-group and the H-group than for the control. After incubation with dissolved tablets for 1 h, the lethal rate of Staphylococcus aureus and Escherichia coli O157:H7 for tablets containing the herbs was lower than that for the control. In the organoleptic assessment test, the L-group and the control were preferred to the M-group and the H-group. During storage at 25 °C for two months, the viability of lactobacilli in tablets containing the herbs was similar to that in the control. In conclusion, the formulation of the L-group has the best characteristics.

[1]  G. Ren,et al.  Relationship between antimicrobial activity and amphipathic structure of ginsenosides , 2020 .

[2]  S. Garcia,et al.  Probiotic creamy soy sauce with Lactobacillus plantarum BG 112 , 2019, British Food Journal.

[3]  Hui Zhang,et al.  Microwave-Assisted Degradation of Polysaccharide from Polygonatum sibiricum and Antioxidant Activity. , 2019, Journal of food science.

[4]  Cheng-Ling Tang,et al.  Chemical Constituents of Polygonatum sibiricum , 2019, Chemistry of Natural Compounds.

[5]  S. Garcia,et al.  Soymilk with okara flour fermented by Lactobacillus acidophilus: Simplex-centroid mixture design applied in the elaboration of probiotic creamy sauce and storage stability , 2018, LWT.

[6]  Hui Cao,et al.  A Review: The Bioactivities and Pharmacological Applications of Polygonatum sibiricum polysaccharides , 2018, Molecules.

[7]  BoKyung Moon,et al.  Evaluation of umami taste in mushroom extracts by chemical analysis, sensory evaluation, and an electronic tongue system. , 2016, Food chemistry.

[8]  H. Zhang,et al.  Lactobacillus plantarum CCFM639 alleviates aluminium toxicity , 2015, Applied Microbiology and Biotechnology.

[9]  M. Hulver,et al.  Dietary supplementation of chinese ginseng prevents obesity and metabolic syndrome in high-fat diet-fed mice. , 2014, Journal of medicinal food.

[10]  A. Graziottin,et al.  Can Lactobacillus fermentum LF10 and Lactobacillus acidophilus LA02 in a Slow-release Vaginal Product be Useful for Prevention of Recurrent Vulvovaginal Candidiasis?: A Clinical Study , 2014, Journal of clinical gastroenterology.

[11]  M. Tripathi,et al.  Probiotic functional foods: Survival of probiotics during processing and storage , 2014 .

[12]  M. Baracat,et al.  Development of effervescent products, in powder and tablet form, supplemented with probiotics Lactobacillus acidophilus and Saccharomyces boulardii , 2013 .

[13]  Y. Yusof,et al.  Compressibility and Dissolution Characteristics of Mixed Fruit Tablets Made from Guava and Pitaya Fruit Powders. , 2013 .

[14]  S. So,et al.  The world ginseng market and the ginseng (Korea) , 2013, Journal of ginseng research.

[15]  M. Coman,et al.  Functional foods as carriers for SYNBIO®, a probiotic bacteria combination. , 2012, International journal of food microbiology.

[16]  P. Russo,et al.  Probiotic features of Lactobacillus plantarum mutant strains , 2012, Applied Microbiology and Biotechnology.

[17]  Heping Zhang,et al.  Production and Characterization of Antifungal Compounds Produced by Lactobacillus plantarum IMAU10014 , 2012, PloS one.

[18]  Marcílio Cunha-Filho,et al.  Development of effervescent tablets containing benznidazole complexed with cyclodextrin , 2011, The Journal of pharmacy and pharmacology.

[19]  T. Klaenhammer,et al.  Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid , 2011, Proceedings of the National Academy of Sciences.

[20]  P. Rutgeerts,et al.  Impact of lipoteichoic acid modification on the performance of the probiotic Lactobacillus rhamnosus GG in experimental colitis , 2010, Clinical and experimental immunology.

[21]  M. Villaran,et al.  Microencapsulation of a probiotic and prebiotic in alginate-chitosan capsules improves survival in simulated gastro-intestinal conditions. , 2010, International journal of food microbiology.

[22]  G. Giraffa,et al.  Importance of lactobacilli in food and feed biotechnology. , 2010, Research in microbiology.

[23]  Mushir M. Ali,et al.  Development and evaluation of acid-buffering bioadhesive vaginal tablet for mixed vaginal infections , 2007, AAPS PharmSciTech.

[24]  M. Roberfroid,et al.  Dietary modulation of the human colonic microbiota: updating the concept of prebiotics , 2004, Nutrition Research Reviews.

[25]  S. Salminen,et al.  Probiotics: an overview of beneficial effects , 2002, Antonie van Leeuwenhoek.

[26]  Zhibing Zhang,et al.  Encapsulation of Probiotic Bacteria Lactobacillus Acidophilus by Direct Compression , 2002 .

[27]  W. Holzapfel,et al.  Introduction to pre- and probiotics , 2002 .

[28]  D Matteuzzi,et al.  Technological and biological evaluation of tablets containing different strains of lactobacilli for vaginal administration. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[29]  G. Mazzanti,et al.  Antimicrobial Activity of Ginsenosides , 1998 .

[30]  Graeme Newell,et al.  Expanded Tables for Multiple Comparison Procedures in the Analysis of Ranked Data , 1987 .