TNF and TNFR Family Members and B Cell Activation

[1]  C. Gordon,et al.  Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial) , 2014, Annals of the rheumatic diseases.

[2]  D. Rawlings,et al.  CD4+ T Cells and CD40 Participate in Selection and Homeostasis of Peripheral B Cells , 2014, The Journal of Immunology.

[3]  P. Johnston,et al.  Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly , 2014, Nature Communications.

[4]  M. Shlomchik,et al.  Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. , 2013, Cell reports.

[5]  K. Fairfax,et al.  The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity , 2013, Cytokine & Growth Factor Reviews.

[6]  M. Genovese,et al.  Efficacy and Safety of Belimumab in Patients with Rheumatoid Arthritis: A Phase II, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study , 2013, The Journal of Rheumatology.

[7]  C. Putterman,et al.  Development of systemic lupus erythematosus in NZM 2328 mice in the absence of any single BAFF receptor. , 2013, Arthritis and rheumatism.

[8]  M. Genovese,et al.  Tabalumab in rheumatoid arthritis patients with an inadequate response to methotrexate and naive to biologic therapy: a phase II, randomized, placebo-controlled trial. , 2013, Arthritis and rheumatism.

[9]  D. Cantrell,et al.  The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway , 2013, Immunity.

[10]  M. Genovese,et al.  Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors , 2012, Annals of the rheumatic diseases.

[11]  K. Lam,et al.  Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival , 2012, Proceedings of the National Academy of Sciences.

[12]  G. Bishop,et al.  Roles of the Kinase TAK1 in TRAF6-Dependent Signaling by CD40 and Its Oncogenic Viral Mimic, LMP1 , 2012, PloS one.

[13]  G. Koncz,et al.  The Fas/CD95 Receptor Regulates the Death of Autoreactive B Cells and the Selection of Antigen-Specific B Cells , 2012, Front. Immun..

[14]  P. Casali,et al.  Immunoglobulin class-switch DNA recombination: induction, targeting and beyond , 2012, Nature Reviews Immunology.

[15]  M. Shlomchik,et al.  Germinal center selection and the development of memory B and plasma cells , 2012, Immunological reviews.

[16]  P. Krammer,et al.  Regulation of CD95/Fas signaling at the DISC , 2011, Cell Death and Differentiation.

[17]  M. Petri,et al.  A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus. , 2011, Arthritis and rheumatism.

[18]  J. Platt,et al.  TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow. , 2011, Blood.

[19]  Julia Jellusova,et al.  Signaling by the tumor necrosis factor receptor superfamily in B‐cell biology and disease , 2011, Immunological reviews.

[20]  R. V. van Vollenhoven,et al.  Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial. , 2011, Arthritis and rheumatism.

[21]  Xi Chen,et al.  CD154-CD40 interactions in the control of murine B cell hematopoiesis , 2011, Journal of leukocyte biology.

[22]  D. Vaux,et al.  Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. , 2011, Blood.

[23]  M. Petri,et al.  Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial , 2011, The Lancet.

[24]  R. Döffinger,et al.  The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88 , 2010, Nature Immunology.

[25]  T. Manser,et al.  Expression of Cellular FLIP by B Cells Is Required for Their Participation in an Immune Response , 2010, The Journal of Immunology.

[26]  D. Teachey,et al.  Advances in the management and understanding of autoimmune lymphoproliferative syndrome (ALPS) , 2010, British journal of haematology.

[27]  S. Ghosh,et al.  The NF-kappaB family of transcription factors and its regulation. , 2009, Cold Spring Harbor perspectives in biology.

[28]  C. Cunningham-Rundles,et al.  Autoimmunity in common variable immunodeficiency , 2009, Current allergy and asthma reports.

[29]  F. Bonilla,et al.  Pathogenesis, Diagnosis, and Management of Primary Antibody Deficiencies and Infections , 2009, Clinical Microbiology Reviews.

[30]  A. Rolink,et al.  Crucial Role for BAFF-BAFF-R Signaling in the Survival and Maintenance of Mature B Cells , 2009, PloS one.

[31]  M. Hahne,et al.  The proteoglycan (heparan sulfate proteoglycan) binding domain of APRIL serves as a platform for ligand multimerization andcross‐linking , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[32]  R. Noelle,et al.  Molecular mechanism and function of CD40/CD40L engagement in the immune system , 2009, Immunological reviews.

[33]  Y. Kadono,et al.  TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses , 2009, PloS one.

[34]  M. Turner,et al.  B‐cell responses to B‐cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta , 2008, European journal of immunology.

[35]  J. Keats,et al.  Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling , 2008, Nature Immunology.

[36]  K. Rajewsky,et al.  Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. , 2008, Immunity.

[37]  K. Rajewsky,et al.  BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells , 2008, Proceedings of the National Academy of Sciences.

[38]  O. Donzé,et al.  APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa. , 2008, The Journal of clinical investigation.

[39]  M. Akkoyunlu,et al.  Deficient TACI Expression on B Lymphocytes of Newborn Mice Leads to Defective Ig Secretion in Response to BAFF or APRIL1 , 2008, The Journal of Immunology.

[40]  F. Mackay,et al.  TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. , 2008, Immunity.

[41]  C. Cunningham-Rundles Autoimmune Manifestations in Common Variable Immunodeficiency , 2008, Journal of Clinical Immunology.

[42]  Meit A. Bjorndahl,et al.  Articles on similar topics can be found in the following Blood collections , 2006 .

[43]  S. Korsmeyer,et al.  Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. , 2008, Blood.

[44]  D. Jelinek,et al.  Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation1 , 2007, The Journal of Immunology.

[45]  G. Bishop,et al.  Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. , 2007, Immunity.

[46]  H. Ding,et al.  NF-κB2 mutation targets TRAF1 to induce lymphomagenesis , 2007 .

[47]  J. Sundberg,et al.  Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. , 2007, Immunity.

[48]  M. Karin,et al.  Regulation of late B cell differentiation by intrinsic IKKα-dependent signals , 2007, Proceedings of the National Academy of Sciences.

[49]  S. Yonehara,et al.  Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes. , 2007, Immunology letters.

[50]  J. Pelkonen,et al.  The CD40-induced protection against CD95-mediated apoptosis is associated with a rapid upregulation of anti-apoptotic c-FLIP. , 2007, Molecular immunology.

[51]  Hana Kim,et al.  A Fourth IκB Protein within the NF-κB Signaling Module , 2007, Cell.

[52]  M. Karin,et al.  Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production , 2007, Nature Immunology.

[53]  G. Cheng,et al.  Rescue of TRAF3-null mice by p100 NF-κB deficiency , 2006, The Journal of experimental medicine.

[54]  A. Tarakhovsky,et al.  BAFF controls B cell metabolic fitness through a PKCβ- and Akt-dependent mechanism , 2006, The Journal of experimental medicine.

[55]  K. Rajewsky,et al.  Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. , 2006, Immunity.

[56]  C. Mackay,et al.  BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders. , 2005, Human pathology.

[57]  R. Geha,et al.  TACI is mutant in common variable immunodeficiency and IgA deficiency , 2005, Nature Genetics.

[58]  J. Pers,et al.  BAFF Overexpression Is Associated with Autoantibody Production in Autoimmune Diseases , 2005, Annals of the New York Academy of Sciences.

[59]  Yen-Ming Hsu,et al.  Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA. , 2005, Biochemistry.

[60]  R. Geha,et al.  TACI and BAFF-R mediate isotype switching in B cells , 2005, The Journal of experimental medicine.

[61]  T. Manser,et al.  B Cells Expressing Bcl-2 and a Signaling-Impaired BAFF-Specific Receptor Fail to Mature and Are Deficient in the Formation of Lymphoid Follicles and Germinal Centers1 , 2004, The Journal of Immunology.

[62]  R. Brink,et al.  TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. , 2004, Immunity.

[63]  J. Kutok,et al.  TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology1 , 2004, The Journal of Immunology.

[64]  C. Mackay,et al.  B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells1 , 2004, The Journal of Immunology.

[65]  E. Harhaj,et al.  Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation* , 2004, Journal of Biological Chemistry.

[66]  A. Hoffmann,et al.  Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[67]  G. Xiao,et al.  Induction of p100 Processing by NF-κB-inducing Kinase Involves Docking IκB Kinase α (IKKα) to p100 and IKKα-mediated Phosphorylation* , 2004, Journal of Biological Chemistry.

[68]  J. Tschopp,et al.  The anti‐apoptotic factor Bcl‐2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF , 2004, European journal of immunology.

[69]  M. Scott,et al.  Cutting Edge: BAFF Regulates CD21/35 and CD23 Expression Independent of Its B Cell Survival Function , 2004, The Journal of Immunology.

[70]  R. Bram,et al.  BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells , 2004, The Journal of experimental medicine.

[71]  Kim L Kusser,et al.  CD40, but Not CD154, Expression on B Cells Is Necessary for Optimal Primary B Cell Responses 1 , 2003, The Journal of Immunology.

[72]  Sambasiva P Rao,et al.  Normal Induction but Attenuated Progression of Germinal Center Responses in BAFF and BAFF-R Signaling–Deficient Mice , 2003, The Journal of experimental medicine.

[73]  I. Maclennan,et al.  NF-κB1 p50 Is Required for BLyS Attenuation of Apoptosis but Dispensable for Processing of NF-κB2 p100 to p52 in Quiescent Mature B Cells1 , 2003, The Journal of Immunology.

[74]  G. Bishop,et al.  The CD40-CD154 interaction in B cell-T cell liaisons. , 2003, Cytokine & growth factor reviews.

[75]  C. Hayes,et al.  Enforced bcl-xL Gene Expression Restored Splenic B Lymphocyte Development in BAFF-R Mutant Mice1 , 2003, The Journal of Immunology.

[76]  H. Shu,et al.  TNFR-Associated Factor-3 Is Associated With BAFF-R and Negatively Regulates BAFF-R-Mediated NF-κB Activation and IL-10 Production , 2002, The Journal of Immunology.

[77]  T. Yasui,et al.  Short-circuiting long-lived humoral immunity by the heightened engagement of CD40. , 2002, The Journal of clinical investigation.

[78]  F. Alt,et al.  TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. , 2001, Immunity.

[79]  Michael Karin,et al.  Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway , 2001, Science.

[80]  M. Scott,et al.  An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway , 2001, Science.

[81]  F. Weih,et al.  Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines1 , 2001, The Journal of Immunology.

[82]  V. Dixit,et al.  Activation and accumulation of B cells in TACI-deficient mice , 2001, Nature Immunology.

[83]  K. Lam,et al.  B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses , 2001, Molecular and Cellular Biology.

[84]  P. Krammer,et al.  Flice-Inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis , 2001, The Journal of experimental medicine.

[85]  S. Akira,et al.  Iκb Kinase α Is Essential for Mature B Cell Development and Function , 2001, The Journal of experimental medicine.

[86]  L. Schneider X-linked hyper IgM syndrome , 2000, Clinical reviews in allergy & immunology.

[87]  H. Shu,et al.  B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[88]  J. Inoue,et al.  TNF Receptor Family Member BCMA (B Cell Maturation) Associates with TNF Receptor-Associated Factor (TRAF) 1, TRAF2, and TRAF3 and Activates NF-κB, Elk-1, c-Jun N-Terminal Kinase, and p38 Mitogen-Activated Protein Kinase1 , 2000, The Journal of Immunology.

[89]  M. Matsumoto,et al.  Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase1 , 2000, The Journal of Immunology.

[90]  V. Dixit,et al.  Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI , 2000, Current Biology.

[91]  A. Lobito,et al.  Inhibition of Fas‐mediated apoptosis by the B cell antigen receptor through c‐FLIP , 2000, European journal of immunology.

[92]  M. Cancro,et al.  A quantitative-trait locus controlling peripheral B-cell deficiency maps to mouse Chromosome 15 , 2000, Immunogenetics.

[93]  J. Tschopp,et al.  Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations , 1999, The Journal of experimental medicine.

[94]  K. R. Ely,et al.  Differential Requirements for Tumor Necrosis Factor Receptor-associated Factor Family Proteins in CD40-mediated Induction of NF-κB and Jun N-terminal Kinase Activation* , 1999, The Journal of Biological Chemistry.

[95]  Ingo Schmitz,et al.  The Role of c-FLIP in Modulation of CD95-induced Apoptosis* , 1999, The Journal of Biological Chemistry.

[96]  E. Gelfand,et al.  Requirement for dual signals by anti-CD40 and IL-4 for the induction of nuclear factor-kappa B, IL-6, and IgE in human B lymphocytes. , 1998, Journal of immunology.

[97]  M. Kehry,et al.  CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. , 1998, Biochemistry.

[98]  Zhaodan Cao,et al.  NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176 , 1998 .

[99]  A. Leonardi,et al.  Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture , 1998, The Journal of experimental medicine.

[100]  Margot Thome,et al.  Inhibition of death receptor signals by cellular FLIP , 1997, Nature.

[101]  F. Alt,et al.  CD40 expression and function in murine B cell ontogeny. , 1996, International immunology.

[102]  M. Cooper,et al.  Expression and function of Fas antigen on activated murine B cells , 1996, European journal of immunology.

[103]  B Zheng,et al.  Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. , 1995, Journal of immunology.

[104]  H. Wortis,et al.  B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[105]  P. Linsley,et al.  Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses , 1995, European journal of immunology.

[106]  F. Alt,et al.  CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[107]  M. Shlomchik,et al.  The role of B cells in lpr/lpr-induced autoimmunity , 1994, The Journal of experimental medicine.

[108]  R. Flavell,et al.  Mice deficient for the CD40 ligand. , 1994, Immunity.

[109]  N. Yoshida,et al.  The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. , 1994, Immunity.

[110]  R. Geha,et al.  Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2 , 1994, The Journal of experimental medicine.

[111]  P. Lipsky,et al.  Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells. , 1994, Journal of immunology.

[112]  T. Kipps,et al.  Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal , 1993, The Journal of experimental medicine.

[113]  A. Fischer,et al.  CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM , 1993, Nature.

[114]  I. Stamenkovic,et al.  A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[115]  E. Clark,et al.  Molecular and biological characterization of a murine ligand for CD40 , 1992, Nature.

[116]  R. Geha,et al.  Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen , 1992, The Journal of experimental medicine.