Conditioned diminution of the unconditioned skin conductance response.

During Pavlovian conditioning the expression of a conditioned response typically serves as evidence that an association between a conditioned stimulus (CS) and an unconditioned stimulus (UCS) has been learned. However, learning-related changes in the unconditioned response (UCR) produced by a predictable UCS can also develop. In the present study, we investigated learning-related reductions in the magnitude of the unconditioned skin conductance response (SCR). Healthy volunteers participated in a differential conditioning study in which one tone (CS+) was paired with a loud white-noise UCS and a second tone (CS-) was presented alone. In addition, probe trials that consisted of UCS presentations paired with the CS+ (CS + UCS) and CS- (CS - UCS), as well as presentations of the UCS alone were included to assess UCR diminution. SCR and participants' expectations of UCS presentation were monitored during conditioning. Greater diminution of the UCR was observed to the UCS when it followed the CS+ compared to when it followed the CS- or was presented alone. Further, UCR amplitude showed an inverse relationship with the participants' ratings of UCS expectancy. However, conditioned UCR diminution was also observed independent of differential UCS expectancies. Our findings demonstrate conditioned diminution of the unconditioned SCR. Further, these findings suggest that although UCR amplitude is modified by conscious expectations of the UCS, conditioned diminution of the UCR can be expressed independent of learning-related changes in these expectations.

[1]  Peter A. Bandettini,et al.  Neural correlates of unconditioned response diminution during Pavlovian conditioning , 2008, NeuroImage.

[2]  K. Mogg,et al.  A cognitive-motivational analysis of anxiety. , 1998, Behaviour research and therapy.

[3]  R. Baxter.  Diminution and recovery of the UCR in delayed and trace classical GSR conditioning. , 1966, Journal of experimental psychology.

[4]  Test of the conditioning model of neurosis: Differential aversive conditioning of angry and neutral facial expressions in anxiety disorder patients. , 1986 .

[5]  J F Thayer,et al.  Phasic heart period reactions to cued threat and nonthreat stimuli in generalized anxiety disorder. , 2000, Psychophysiology.

[6]  K. E. Petersen,et al.  Electrodermal correlates of extraversion, trait anxiety and schizophrenism. , 1976, Scandinavian journal of psychology.

[7]  P. Bellgowan,et al.  Lesions of the amygdala block conditional hypoalgesia on the tail flick test , 1993, Brain Research.

[8]  Peter A. Bandettini,et al.  Neural substrates of explicit and implicit fear memory , 2009, NeuroImage.

[9]  J. Rust,et al.  Unconditioned response diminution in the skin resistance response. , 1976, The Journal of general psychology.

[10]  K Merikangas,et al.  Fear-potentiated startle in humans: effects of anticipatory anxiety on the acoustic blink reflex. , 1991, Psychophysiology.

[11]  M. Masson,et al.  Using confidence intervals in within-subject designs , 1994, Psychonomic bulletin & review.

[12]  Karin Mogg,et al.  Attentional Bias to Threat: Roles of Trait Anxiety, Stressful Events, and Awareness , 1994, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[13]  FJ Helmstetter,et al.  Lesions of the periaqueductal gray and rostral ventromedial medulla disrupt antinociceptive but not cardiovascular aversive conditional responses , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[14]  A. Schwerdtfeger,et al.  Trait anxiety and autonomic indicators of the processing of threatening information: A cued S1–S2 paradigm , 2006, Biological Psychology.

[15]  P. Lang,et al.  The startle probe response: a new measure of emotion? , 1988, Journal of abnormal psychology.

[16]  N. Balderston,et al.  Conditioning with masked stimuli affects the timecourse of skin conductance responses. , 2010, Behavioral neuroscience.

[17]  A. R. Wagner,et al.  Evolution of a structured connectionist model of Pavlovian conditioning (AESOP). , 1989 .

[18]  E. Cook,et al.  Fearfulness and startle potentiation during aversive visual stimuli. , 2007, Psychophysiology.

[19]  J. Franchina.  Escape behavior and shock intensity: within-subject versus between-groups comparisons. , 1969, Journal of comparative and physiological psychology.

[20]  L. Kamin.  Traumatic avoidance learning: the effects of CS-US interval with a trace-conditioning procedure. , 1954, Journal of comparative and physiological psychology.

[21]  S. Klein,et al.  Pavlovian conditioning and the status of traditional learning theory , 1991 .

[22]  F. Helmstetter,et al.  Classical conditioning of autonomic fear responses is independent of contingency awareness. , 2010, Journal of experimental psychology. Animal behavior processes.

[23]  Peter A. Bandettini,et al.  Learning-related diminution of unconditioned SCR and fMRI signal responses , 2010, NeuroImage.

[24]  H. T. Nguyen,et al.  The role of awareness in delay and trace fear conditioning in humans , 2006, Cognitive, affective & behavioral neuroscience.

[25]  Charles D. Spielberger,et al.  State-Trait Anxiety Inventory for Adults , 2012 .

[26]  H. T. Nguyen,et al.  Expression of conditional fear with and without awareness , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[27]  Issidoros C. Sarinopoulos,et al.  Uncertainty during anticipation modulates neural responses to aversion in human insula and amygdala. , 2010, Cerebral cortex.

[28]  C. Grillon,et al.  Fear-potentiated startle: Relationship to the level of state/trait anxiety in healthy subjects , 1993, Biological Psychiatry.

[29]  Jaime Redondo,et al.  Effects of conditioned stimulus presentation on diminution of the unconditioned response in aversive classical conditioning , 1999, Biological Psychology.

[30]  E. Kimmel.  Judgments of UCS intensity and diminution of the UCR in classical GSR conditioning. , 1967, Journal of experimental psychology.

[31]  C. Grillon,et al.  Baseline and fear-potentiated startle in panic disorder patients , 1994, Biological Psychiatry.

[32]  M. Domjan.  Pavlovian conditioning: a functional perspective. , 2005, Annual review of psychology.

[33]  Christian Grillon,et al.  Effects of experimental context and explicit threat cues on acoustic startle in vietnam veterans with posttraumatic stress disorder , 1998, Biological Psychiatry.