Increased β‐adrenergic inotropy in ventricular myocardium from trpm4‐/‐ mice. (LB666)

RATIONALE: The Trpm4 gene has recently been associated with several disorders, including cardiac conduction diseases and Brugada syndrome. Transient receptor potential member 4 (TRPM4) proteins constitute Ca(2+)‐activated, but Ca(2+)‐impermeable, nonselective cation channels and are expressed both in atrial and in ventricular cardiomyocytes. The physiological function of TRPM4 in the heart remains, however, incompletely understood.

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