论文信息 - Targeting the dimerization interface for irreversible inhibition of HIV-1 protease.

Targeting the dimerization interface for irreversible inhibition of HIV-1 protease.

A novel strategy was used to irreversibly inhibit HIV-1 protease. The inhibitor was designed to form a disulfide bond with Cys95, present at the dimerization interface of HIV-1 protease. The inhibitor was shown to be active against HIV-1 protease with K(inact) = 3.7 microM and V(inact) = 0.012 min(-1).

R. Zutshi | J. Chmielewski | J Chmielewski | R Zutshi

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