Eliminating All Obstacles: Regulated Proteolysis in the Eukaryotic Cell Cycle

Control of many of the periodic events of the cell cycle can now be explained by the intertwined actions of cyclin-dependent kinases and specific proteolytic mechanisms (King et al. 1996xKing, R.W., Deshaies, R.J., Peters, J., and Kirschner, M.W. Science. 1996; 274: 1652–1659CrossRef | PubMed | Scopus (1003)See all ReferencesKing et al. 1996). In general, transitions activated by either phosphorylation or proteolysis share the capacity to be rapidly executed. Both mechanisms are therefore well-suited to promote the abrupt biochemical changes characteristic of cell cycle regulation. Proteolysis, in addition, has the advantage of irreversibility, which may be important for promoting unidirectional transitions and the biochemical remodeling of the cell. It is currently not clear why two distinct mechanisms of ubiquitin-mediated proteolysis are used to promote cell cycle transitions. This should be revealed when the APC-mediated system is better understood.

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