Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors
暂无分享,去创建一个
J. Ramón‐Azcón | N. Montserrat | R. Gomis | A. Novials | R. Gasa | L. Pasquali | A. Wojtusciszyn | C. Enrich | Rebeca Fernández-Ruiz | Ainhoa García-Alamán | Marta Fontcuberta-PiSunyer | C. Broca | J. Vidal | M. Ramos-Rodríguez | J. Servitja | N. Téllez | H. Alves-Figueiredo | Èlia Prades | Laura Clua | Sara Cervantes
[1] P. Lund,et al. Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells , 2022, Nature Biotechnology.
[2] M. Götz,et al. Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches , 2021, Neuron.
[3] M. Bellin,et al. Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device , 2021, Cell reports. Medicine.
[4] G. Warnock,et al. Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes. , 2021, Cell stem cell.
[5] M. Sepehrimanesh,et al. Direct conversion of adult fibroblasts into motor neurons , 2021, STAR protocols.
[6] B. Cox,et al. Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models. , 2021, Cell stem cell.
[7] Xiaochen Bo,et al. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data , 2021, Innovation.
[8] J. I. Izpisúa Belmonte,et al. Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells , 2021, Nature communications.
[9] Yuchen Yang,et al. Direct cell reprogramming: approaches, mechanisms and progress , 2021, Nature Reviews Molecular Cell Biology.
[10] T. Kieffer,et al. Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2 , 2020, Diabetes.
[11] E. Montanya,et al. Pancreatic ductal cells may have a negative effect on human islet transplantation , 2019, PloS one.
[12] R. Gomis,et al. Targeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes , 2019, Science Translational Medicine.
[13] J. Paulo,et al. Diabetes Relief in Mice by Glucose-Sensing Insulin-Secreting Human α-Cells , 2019, Nature.
[14] Gopika G. Nair,et al. Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells , 2019, Nature Cell Biology.
[15] L. Laurent,et al. Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark. , 2018, Biochimica et biophysica acta. Gene regulatory mechanisms.
[16] A. Shapiro,et al. The journey of islet cell transplantation and future development , 2018, Islets.
[17] J. Schug,et al. Reprogramming human gallbladder cells into insulin-producing β-like cells , 2017, PloS one.
[18] P. Berggren,et al. Intraocular in vivo imaging of pancreatic islet cell physiology/pathology , 2017, Molecular metabolism.
[19] G. Rutter,et al. Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene , 2017, Front. Genet..
[20] Geet Duggal,et al. Salmon: fast and bias-aware quantification of transcript expression using dual-phase inference , 2017, Nature Methods.
[21] Deepak Srivastava,et al. In Vivo Cellular Reprogramming: The Next Generation , 2016, Cell.
[22] Shaun Mahony,et al. Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation. , 2016, Cell stem cell.
[23] J. Kerr-Conte,et al. Dynamics of glucose-induced insulin secretion in normal human islets. , 2015, American journal of physiology. Endocrinology and metabolism.
[24] Huiqing Zhou,et al. Choices for Induction of Pluripotency: Recent Developments in Human Induced Pluripotent Stem Cell Reprogramming Strategies , 2015, Stem Cell Reviews and Reports.
[25] A. Clark,et al. Alpha-, Delta- and PP-cells , 2015, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[26] Hongkui Deng,et al. Direct lineage reprogramming: strategies, mechanisms, and applications. , 2015, Cell stem cell.
[27] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[28] D. Gifford,et al. Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells , 2014, Nature Biotechnology.
[29] D. Melton,et al. Generation of Functional Human Pancreatic β Cells In Vitro , 2014, Cell.
[30] Hyun-Jai Cho,et al. Direct Conversion of Adult Skin Fibroblasts to Endothelial Cells by Defined Factors , 2014, Circulation.
[31] James D. Johnson,et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells , 2014, Nature Biotechnology.
[32] Jay W. Shin,et al. A transient disruption of fibroblastic transcriptional regulatory network facilitates trans-differentiation , 2014, Nucleic acids research.
[33] S. Dalle,et al. Proteasome Dysfunction Mediates High Glucose-Induced Apoptosis in Rodent Beta Cells and Human Islets , 2014, PloS one.
[34] R. Maehr,et al. De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts , 2014, Cell reports.
[35] Ying Zhang,et al. Direct reprogramming of human fibroblasts to functional and expandable hepatocytes. , 2014, Cell stem cell.
[36] D. Melton,et al. In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes , 2014, eLife.
[37] D. Gifford,et al. Differentiated human stem cells resemble fetal, not adult, β cells , 2014, Proceedings of the National Academy of Sciences.
[38] J. Slack,et al. Reprogramming of Various Cell Types to a Beta-Like State by Pdx1, Ngn3 and MafA , 2013, PLoS ONE.
[39] J. O'neil,et al. Enrichment of human embryonic stem cell‐derived NKX6.1‐expressing pancreatic progenitor cells accelerates the maturation of insulin‐secreting cells in vivo , 2013, Stem cells.
[40] Joshua C. Chang,et al. Small Molecules Enable Neurogenin 2 to Efficiently Convert Human Fibroblasts to Cholinergic Neurons , 2013, Nature Communications.
[41] Mohammad Wahid Ansari,et al. The legal status of in vitro embryos , 2014 .
[42] J. Miyazaki,et al. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells , 2013, eLife.
[43] J. O'neil,et al. Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice , 2013, Diabetologia.
[44] Daniel C. Factor,et al. Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells , 2013, Nature Biotechnology.
[45] Thomas Vierbuchen,et al. Molecular roadblocks for cellular reprogramming. , 2012, Molecular cell.
[46] G. Warnock,et al. Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice , 2012, Diabetes.
[47] M. Granvik,et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? , 2012, Diabetes.
[48] T. Graf,et al. Historical origins of transdifferentiation and reprogramming. , 2011, Cell stem cell.
[49] Rudolf Jaenisch,et al. Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. , 2011, Cell stem cell.
[50] H. Yoshikawa,et al. Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. , 2011, The Journal of clinical investigation.
[51] Sheng Ding,et al. Reprogramming of human primary somatic cells by OCT4 and chemical compounds. , 2010, Cell stem cell.
[52] V. Vedantham,et al. Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors , 2010, Cell.
[53] M. Palassini,et al. Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program. , 2010, Genome research.
[54] G. Rutter,et al. Identification of genes selectively disallowed in the pancreatic islet , 2010, Islets.
[55] Matthew D. Young,et al. Gene ontology analysis for RNA-seq: accounting for selection bias , 2010, Genome Biology.
[56] Thomas Vierbuchen,et al. Direct conversion of fibroblasts to functional neurons by defined factors , 2010, Nature.
[57] Robin Goland,et al. Generation of pluripotent stem cells from patients with type 1 diabetes , 2009, Proceedings of the National Academy of Sciences.
[58] P. Boulanger,et al. Improved Adenovirus Type 5 Vector-Mediated Transduction of Resistant Cells by Piggybacking on Coxsackie B-Adenovirus Receptor-Pseudotyped Baculovirus , 2009, Journal of Virology.
[59] L. Chan,et al. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. , 2009, Developmental cell.
[60] N. Chao. Faculty Opinions recommendation of In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. , 2008 .
[61] Douglas A. Melton,et al. In vivo reprogramming of adult pancreatic exocrine cells to β-cells , 2008, Nature.
[62] R. Gomis,et al. Identification of the bHLH Factor Math6 as a Novel Component of the Embryonic Pancreas Transcriptional Network , 2008, PloS one.
[63] E. Kroon,et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo , 2008, Nature Biotechnology.
[64] T. Ichisaka,et al. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.
[65] E. Kroon,et al. Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells , 2006, Nature Biotechnology.
[66] S. Yamanaka,et al. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.
[67] P. Boulanger,et al. Enhancement of Adenovirus-Mediated Gene Delivery to Rheumatoid Arthritis Synoviocytes and Synovium by Fiber Modifications: Role of Arginine-Glycine-Aspartic Acid (RGD)- and Non-RGD-Binding Integrins1 , 2005, The Journal of Immunology.
[68] E. Kroon,et al. Efficient differentiation of human embryonic stem cells to definitive endoderm , 2005, Nature Biotechnology.
[69] P. Serup,et al. The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the α- and β-cell lineages in the mouse endocrine pancreas , 2005, Development.
[70] S. Polak‐Charcon,et al. Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[71] Michael R. Barnes,et al. Proendocrine genes coordinate the pancreatic islet differentiation program in vitro. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[72] L. Sussel,et al. The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. , 2004, Developmental biology.
[73] H. Watada,et al. Neurogenin3 and Hepatic Nuclear Factor 1 Cooperate in Activating Pancreatic Expression of Pax4* , 2003, Journal of Biological Chemistry.
[74] L. Sussel,et al. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. , 2000, Development.
[75] L. Sussel,et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. , 2000, Development.
[76] M. German,et al. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. , 1997, Genes & development.
[77] P. Gruss,et al. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas , 1997, Nature.
[78] P. Gruss,et al. The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas , 1997, Nature.
[79] E. Adeghate,et al. Morphological Findings in Long‐Term Pancreatic Tissue Transplants in the Anterior Eye Chamber of Rats , 1990, Pancreas.
[80] Gopika G. Nair,et al. Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro , 2015, The EMBO journal.
[81] M. Vidal,et al. Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells. , 2013, Genes & development.
[82] P Gruss,et al. Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. , 1997, Nature.