A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance
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C. Dieterich | M. Mann | L. Partridge | A. Beyer | Nagarjuna Nagaraj | P. Essers | N. Alic | Sebastian Grönke | Manopriya Chokkalingam | L. Tain | Robert Sehlke | Chirag Jain | M. Rassner | Jenny Froelich | R. Sehlke
[1] H. Fuchs,et al. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease , 2016, Cell.
[2] C. Kahn,et al. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability , 2016, Cell.
[3] L. Partridge,et al. Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice , 2016, Scientific Reports.
[4] R. Aebersold,et al. On the Dependency of Cellular Protein Levels on mRNA Abundance , 2016, Cell.
[5] Alyson W. MacInnes. The role of the ribosome in the regulation of longevity and lifespan extension , 2016, Wiley interdisciplinary reviews. RNA.
[6] L. Partridge,et al. Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila , 2016, Proceedings of the National Academy of Sciences.
[7] José A. Dianes,et al. 2016 update of the PRIDE database and its related tools , 2016, Nucleic Acids Res..
[8] C. Murphy,et al. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators , 2015, Nature.
[9] Shelly K McCrady-Spitzer,et al. Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.
[10] Soyeon Park,et al. Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly , 2015, Scientific Reports.
[11] R. Birner-Gruenberger,et al. Gel‐free mass spectrometry analysis of Drosophila melanogaster heads , 2015, Proteomics.
[12] L. Partridge,et al. The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity , 2015, Cell.
[13] J. Vijg,et al. Genetic evidence for common pathways in human age-related diseases , 2015, Aging cell.
[14] K. Ocorr,et al. PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase. , 2015, Cell reports.
[15] M. Mann,et al. Deep Proteomics of Mouse Skeletal Muscle Enables Quantitation of Protein Isoforms, Metabolic Pathways, and Transcription Factors* , 2015, Molecular & Cellular Proteomics.
[16] C. Murphy,et al. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity , 2014, Nature.
[17] A. Dillin,et al. The role of protein clearance mechanisms in organismal ageing and age-related diseases , 2014, Nature Communications.
[18] M. Mann,et al. Cell-type-resolved quantitative proteomics of murine liver. , 2014, Cell metabolism.
[19] Q. Kong,et al. Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians , 2014, Aging.
[20] Yaning Sun,et al. A mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in Drosophila. , 2014, Cell reports.
[21] Michael J Sailor,et al. Mesoporous silicon sponge as an anti-pulverization structure for high-performance lithium-ion battery anodes , 2014, Nature Communications.
[22] Marco Y. Hein,et al. Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ * , 2014, Molecular & Cellular Proteomics.
[23] Gary D Bader,et al. A draft map of the human proteome , 2014, Nature.
[24] Wei Xie,et al. Knockdown expression of eukaryotic initiation factor 5 C-terminal domain containing protein extends lifespan in Drosophila melanogaster. , 2014, Biochemical and biophysical research communications.
[25] J. Steitz,et al. The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones , 2014, Cell.
[26] Jennifer M. A. Tullet,et al. Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging , 2014, Cell reports.
[27] Andrew R. Jones,et al. ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination , 2014, Nature Biotechnology.
[28] P. Bickel,et al. System wide analyses have underestimated protein abundances and the importance of transcription in mammals , 2012, PeerJ.
[29] A. Duttaroy,et al. Spargel/dPGC-1 Is a New Downstream Effector in the Insulin–TOR Signaling Pathway in Drosophila , 2013, Genetics.
[30] Veit Schwämmle,et al. Assessment and improvement of statistical tools for comparative proteomics analysis of sparse data sets with few experimental replicates. , 2013, Journal of proteome research.
[31] Ronald G. Tepper,et al. PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity , 2013, Cell.
[32] H. Korswagen,et al. Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism , 2013, Molecular systems biology.
[33] M. Hochstrasser,et al. Molecular architecture and assembly of the eukaryotic proteasome. , 2013, Annual review of biochemistry.
[34] Manuel Serrano,et al. The Hallmarks of Aging , 2013, Cell.
[35] V. Gorgoulis,et al. Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[36] S. Austad,et al. Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa). , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.
[37] Howard Y. Chang,et al. Long Noncoding RNAs: Cellular Address Codes in Development and Disease , 2013, Cell.
[38] A. Bratić,et al. The role of mitochondria in aging. , 2013, The Journal of clinical investigation.
[39] M. Mann,et al. The coming age of complete, accurate, and ubiquitous proteomes. , 2013, Molecular cell.
[40] Seung-Jae V. Lee,et al. Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. , 2013, Cell metabolism.
[41] D. Walker,et al. Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila , 2012, Proceedings of the National Academy of Sciences.
[42] M. Tatar,et al. Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain , 2012, Aging cell.
[43] Peter M. Douglas,et al. RPN-6 determines C. elegans longevity under proteotoxic stress conditions , 2012, Nature.
[44] Linda Partridge,et al. Ageing as a Risk Factor for Disease , 2012, Current Biology.
[45] C. Kahn,et al. Tissue–Specific Insulin Signaling, Metabolic Syndrome, and Cardiovascular Disease , 2012, Arteriosclerosis, thrombosis, and vascular biology.
[46] N. Barzilai,et al. The Critical Role of Metabolic Pathways in Aging , 2012, Diabetes.
[47] Sue Fletcher,et al. Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements , 2012, Cellular and Molecular Life Sciences.
[48] Reinhard Guthke,et al. Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. , 2012, Cell metabolism.
[49] Mark Bradley,et al. Peptides for cell-selective drug delivery. , 2012, Trends in pharmacological sciences.
[50] A. Sali,et al. The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together , 2011, Proceedings of the National Academy of Sciences.
[51] A. Uitterlinden,et al. Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways , 2011, AGE.
[52] D. Walker,et al. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. , 2011, Cell metabolism.
[53] M. Mann,et al. System-wide Perturbation Analysis with Nearly Complete Coverage of the Yeast Proteome by Single-shot Ultra HPLC Runs on a Bench Top Orbitrap* , 2011, Molecular & Cellular Proteomics.
[54] L. Partridge,et al. dFOXO-independent effects of reduced insulin-like signaling in Drosophila , 2011, Aging cell.
[55] Christopher J. Murakami,et al. Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae , 2011, PLoS genetics.
[56] S. Gygi,et al. Structural Defects in the Regulatory Particle-Core Particle Interface of the Proteasome Induce a Novel Proteasome Stress Response* , 2011, The Journal of Biological Chemistry.
[57] Min Jae Lee,et al. An asymmetric interface between the regulatory particle and core particle of the proteasome , 2011, Nature Structural &Molecular Biology.
[58] M. Tatar,et al. Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan , 2011, Aging cell.
[59] M. Ristow,et al. Extending life span by increasing oxidative stress. , 2011, Free radical biology & medicine.
[60] Irene Papatheodorou,et al. Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling , 2011, Molecular systems biology.
[61] N. Barzilai,et al. Impaired IGF1R signaling in cells expressing longevity‐associated human IGF1R alleles , 2011, Aging cell.
[62] M. Selbach,et al. Global quantification of mammalian gene expression control , 2011, Nature.
[63] Ivan Dikic,et al. The spatial and temporal organization of ubiquitin networks , 2011, Nature Reviews Molecular Cell Biology.
[64] M. Mann,et al. Andromeda: a peptide search engine integrated into the MaxQuant environment. , 2011, Journal of proteome research.
[65] Peter J. Bickel,et al. The Developmental Transcriptome of Drosophila melanogaster , 2010, Nature.
[66] Saurabh Sinha,et al. FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system , 2010, Nucleic Acids Res..
[67] Stephen Guest,et al. DroID 2011: a comprehensive, integrated resource for protein, transcription factor, RNA and gene interactions for Drosophila , 2010, Nucleic Acids Res..
[68] N. Perrimon,et al. FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging , 2010, Cell.
[69] L. Partridge,et al. DILP‐producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition , 2010, Aging cell.
[70] Linda Partridge,et al. Extending Healthy Life Span—From Yeast to Humans , 2010, Science.
[71] C. Kenyon. The genetics of ageing , 2010, Nature.
[72] T. Andrews,et al. Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides , 2010, PLoS genetics.
[73] C. Frei,et al. The Drosophila PGC‐1 homologue Spargel coordinates mitochondrial activity to insulin signalling , 2010, The EMBO journal.
[74] Roded Sharan,et al. Associating Genes and Protein Complexes with Disease via Network Propagation , 2010, PLoS Comput. Biol..
[75] Jaehyoung Cho,et al. Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain , 2009, Current Biology.
[76] Janet M. Thornton,et al. Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span , 2009, Science.
[77] Subhash D. Katewa,et al. 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila , 2009, Cell.
[78] B. Edgar,et al. Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut , 2009, Cell.
[79] Mikael Bodén,et al. MEME Suite: tools for motif discovery and searching , 2009, Nucleic Acids Res..
[80] Nicholas T. Ingolia,et al. Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling , 2009, Science.
[81] Yael H. Edrey,et al. Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat , 2009, Proceedings of the National Academy of Sciences.
[82] Keiji Tanaka,et al. Molecular mechanisms of proteasome assembly , 2009, Nature Reviews Molecular Cell Biology.
[83] Masayuki Miura,et al. Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process , 2008, Molecular and Cellular Biology.
[84] M. Mann,et al. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification , 2008, Nature Biotechnology.
[85] Laurent Seroude,et al. Characterization of the Drosophila Gene‐Switch system in aging studies: a cautionary tale , 2008, Aging cell.
[86] S. Ratcliffe,et al. GEEQBOX: A MATLAB Toolbox for Generalized Estimating Equations and Quasi-Least Squares , 2008 .
[87] M. Pankratz,et al. Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling. , 2008, Cell metabolism.
[88] R. Scarpulla. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. , 2008, Physiological reviews.
[89] Sébastien Lê,et al. FactoMineR: An R Package for Multivariate Analysis , 2008 .
[90] D. Leahy,et al. Functionally significant insulin-like growth factor I receptor mutations in centenarians , 2008, Proceedings of the National Academy of Sciences.
[91] A. Teleman,et al. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. , 2008, Cell metabolism.
[92] Seung-Jae V. Lee,et al. Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans , 2007, Proceedings of the National Academy of Sciences.
[93] T. Johnson,et al. Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans , 2007, PLoS biology.
[94] Linda Partridge,et al. Optimization of dietary restriction protocols in Drosophila. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.
[95] M. Figueiredo-Pereira,et al. Aging perturbs 26S proteasome assembly in Drosophila melanogaster , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[96] D. Moore,et al. Alterations in xenobiotic metabolism in the long‐lived Little mice , 2007, Aging cell.
[97] M. Birnbaum,et al. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator , 2007, Nature.
[98] Patrick G. A. Pedrioli,et al. A high-quality catalog of the Drosophila melanogaster proteome , 2007, Nature Biotechnology.
[99] Nicholas D Bonawitz,et al. Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. , 2007, Cell metabolism.
[100] Robert M Peitzsch,et al. High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO. , 2007, Physiological genomics.
[101] R. Maeda,et al. An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases , 2007, Proceedings of the National Academy of Sciences.
[102] P. Kapahi,et al. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans , 2007, Aging cell.
[103] Seung-Jae V. Lee,et al. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans , 2007, Aging cell.
[104] Janet M Thornton,et al. Evolutionary conservation of regulated longevity assurance mechanisms , 2007, Genome Biology.
[105] Thomas Lengauer,et al. Improved scoring of functional groups from gene expression data by decorrelating GO graph structure , 2006, Bioinform..
[106] A. Goldberg,et al. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. , 2006, Journal of the American Society of Nephrology : JASN.
[107] A. Betik,et al. No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.
[108] Michael R. Green,et al. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation , 2006, Nature Genetics.
[109] J. Keller,et al. Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome? , 2006, Free radical biology & medicine.
[110] Donald L Riddle,et al. Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. , 2005, Genome research.
[111] A. Bauer,et al. Analyzing protein complexes in Drosophila with tandem affinity purification–mass spectrometry , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.
[112] E. Hafen,et al. Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body , 2004, Science.
[113] Cori Bargmann,et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans , 2003, Nature.
[114] M. Daly,et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.
[115] M. Mann,et al. Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics. , 2003, Analytical chemistry.
[116] P. Puigserver,et al. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. , 2003, Endocrine reviews.
[117] Matthias Blüher,et al. Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue , 2003, Science.
[118] D. Accili,et al. Mouse models of insulin resistance. , 2004, American journal of physiology. Endocrinology and metabolism.
[119] Andrew G Fraser,et al. Rates of Behavior and Aging Specified by Mitochondrial Function During Development , 2002, Science.
[120] Koutarou D. Kimura,et al. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. , 2000, Science.
[121] C. Franceschi,et al. Fibroblast cultures from healthy centenarians have an active proteasome , 2000, Experimental Gerontology.
[122] B. Ames,et al. Oxidative damage and mitochondrial decay in aging. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[123] C. Kenyon,et al. A C. elegans mutant that lives twice as long as wild type , 1993, Nature.
[124] R. Scarpulla,et al. Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. , 1993, Genes & development.
[125] R. Scarpulla,et al. NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells. , 1990, Genes & development.
[126] Y. Wei,et al. Liver mitochondrial respiratory functions decline with age. , 1989, Biochemical and biophysical research communications.
[127] D. Harman. Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.
[128] the original work is properly cited. , 2022 .