The Molecular Control of Regulatory T Cell Induction.

[1]  N. Fazilleau,et al.  Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors , 2015, Nature Immunology.

[2]  Cindy Gross,et al.  CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens. , 2015, Immunity.

[3]  Nicole M. Chapman,et al.  mTOR Links Environmental Signals to T Cell Fate Decisions , 2015, Front. Immunol..

[4]  Susan M. Schlenner,et al.  Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3+ and Foxp3− T cells , 2014, Immunology and cell biology.

[5]  T. Myers,et al.  Dynamic changes in E-protein activity regulate T reg cell development , 2014, The Journal of experimental medicine.

[6]  B. Seddon,et al.  Differential Requirement for IL-2 and IL-15 during Bifurcated Development of Thymic Regulatory T Cells , 2014, The Journal of Immunology.

[7]  C. Piccirillo,et al.  Functional dynamics of Foxp3+ regulatory T cells in mice and humans , 2014, Immunological reviews.

[8]  Taeko Dohi,et al.  The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells , 2014, Nature Immunology.

[9]  Piero Carninci,et al.  Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation , 2014, Proceedings of the National Academy of Sciences.

[10]  M. Farrar,et al.  Tumor necrosis factor receptor superfamily costimulation couples T cell receptor signal strength to thymic regulatory T cell differentiation , 2014, Nature immunology.

[11]  Huidong Shi,et al.  Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. , 2014, Immunity.

[12]  J. Grainger,et al.  Thymocyte apoptosis drives the intrathymic generation of regulatory T cells , 2014, Proceedings of the National Academy of Sciences.

[13]  M. Tomita,et al.  Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells , 2013, Nature.

[14]  A. Rudensky,et al.  Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation , 2013, Nature.

[15]  W. Garrett,et al.  The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis , 2013, Science.

[16]  Susan M. Schlenner,et al.  Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells , 2013, Nature Immunology.

[17]  D. Singer,et al.  Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. , 2013, Immunity.

[18]  Peter Vogel,et al.  mTORC1 couples immune signals and metabolic programming to establish Treg cell function , 2013, Nature.

[19]  J. Bluestone,et al.  DGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability , 2013, PloS one.

[20]  Hiromasa Morikawa,et al.  Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression , 2013, Proceedings of the National Academy of Sciences.

[21]  T. Denning,et al.  Thymus-derived regulatory T cells control tolerance to commensal microbiota , 2013, Nature.

[22]  D. Pennington,et al.  Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27–CD70 pathway , 2013, The Journal of experimental medicine.

[23]  R. Geffers,et al.  Active Demethylation of the Foxp3 Locus Leads to the Generation of Stable Regulatory T Cells within the Thymus , 2013, The Journal of Immunology.

[24]  A. E. Sousa,et al.  Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery , 2013, Proceedings of the National Academy of Sciences.

[25]  R. Zamoyska,et al.  T cell receptor signalling networks: branched, diversified and bounded , 2013, Nature Reviews Immunology.

[26]  R. D. Hatton,et al.  The Th17 family: flexibility follows function , 2013, Immunological reviews.

[27]  L. Turka,et al.  An obligate cell-intrinsic function for CD28 in Tregs. , 2013, The Journal of clinical investigation.

[28]  R. Sellers,et al.  Helios Induces Epigenetic Silencing of Il2 Gene Expression in Regulatory T Cells , 2013, The Journal of Immunology.

[29]  R. Morita,et al.  Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis , 2013, Nature Immunology.

[30]  A. Kühl,et al.  IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. , 2012, Immunity.

[31]  K. Nakai,et al.  T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. , 2012, Immunity.

[32]  Michael Q. Zhang,et al.  Novel Foxo1-dependent transcriptional programs control Treg cell function , 2012, Nature.

[33]  Shane J. Neph,et al.  Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification , 2012, Cell.

[34]  C. Leslie,et al.  Transcription factor Foxp3 and its protein partners form a complex regulatory network , 2012, Nature Immunology.

[35]  C. Piccirillo,et al.  Functional stability of Foxp3+ regulatory T cells. , 2012, Trends in molecular medicine.

[36]  Hongbo Chi,et al.  Regulation and function of mTOR signalling in T cell fate decisions , 2012, Nature Reviews Immunology.

[37]  D. Sabatini,et al.  mTOR Signaling in Growth Control and Disease , 2012, Cell.

[38]  A. Iavarone,et al.  E protein transcription factors are required for the development of CD4(+) lineage T cells. , 2012, Immunity.

[39]  H. Waldmann,et al.  Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. , 2012, Immunity.

[40]  C. Benoist,et al.  Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion , 2012, Proceedings of the National Academy of Sciences.

[41]  C. Hsieh,et al.  Selection of regulatory T cells in the thymus , 2012, Nature Reviews Immunology.

[42]  A. Rudensky,et al.  Extrathymically generated regulatory T cells control mucosal TH2 inflammation , 2012, Nature.

[43]  L. Walker,et al.  The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses , 2011, Nature Reviews Immunology.

[44]  T. Chatila,et al.  A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. , 2011, Immunity.

[45]  L. Klein,et al.  B7/CD28 in Central Tolerance: Costimulation Promotes Maturation of Regulatory T Cell Precursors and Prevents Their Clonal Deletion , 2011, Front. Immun..

[46]  E. Sgouroudis,et al.  Single-Cell Analysis of the Human T Regulatory Population Uncovers Functional Heterogeneity and Instability within FOXP3+ Cells , 2011, The Journal of Immunology.

[47]  A. G. Betz,et al.  Foxp3 Interacts with c-Rel to Mediate NF-κB Repression , 2011, PloS one.

[48]  David K. Finlay,et al.  Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism , 2011, Immunity.

[49]  P. Worley,et al.  The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling , 2011, Nature Immunology.

[50]  K. Honda,et al.  Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species , 2011, Science.

[51]  Daniel R. Beisner,et al.  Foxo transcription factors control regulatory T cell development and function. , 2010, Immunity.

[52]  C. Anasetti,et al.  Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling. , 2010, Blood.

[53]  Greg M. Delgoffe,et al.  The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. , 2010, Immunity.

[54]  David Baltimore,et al.  Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses , 2010, Cell.

[55]  Hongbo Chi,et al.  S1P1-mTOR axis directs the reciprocal differentiation of TH1 and regulatory T cells , 2010, Nature Immunology.

[56]  J. Allison,et al.  TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo , 2010, The Journal of experimental medicine.

[57]  R. DePinho,et al.  Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells , 2010, Nature Immunology.

[58]  R. DePinho,et al.  Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells , 2010, The Journal of experimental medicine.

[59]  M. Farrar,et al.  Cutting Edge: CD28 and c-Rel–Dependent Pathways Initiate Regulatory T Cell Development , 2010, The Journal of Immunology.

[60]  Y. Belkaid,et al.  Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells , 2010, The Journal of Immunology.

[61]  A. Rudensky,et al.  Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate , 2010, Nature.

[62]  M. F. Shannon,et al.  c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells , 2009, The Journal of experimental medicine.

[63]  S. Ghosh,et al.  Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. , 2009, Immunity.

[64]  M. Greene,et al.  Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. , 2009, Immunity.

[65]  L. Klein,et al.  Antigen presentation in the thymus for positive selection and central tolerance induction , 2009, Nature Reviews Immunology.

[66]  C. Akdis,et al.  Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells , 2009, The Journal of experimental medicine.

[67]  A. Rudensky,et al.  Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells , 2009, Nature Immunology.

[68]  T. Nomura,et al.  Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. , 2009, Immunity.

[69]  J. Bluestone,et al.  Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo , 2009, Nature Immunology.

[70]  Greg M. Delgoffe,et al.  mTOR: taking cues from the immune microenvironment , 2009, Immunology.

[71]  Christian Schmidl,et al.  Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. , 2009, Genome research.

[72]  A. Rudensky,et al.  Cutting Edge: TCR Stimulation Is Sufficient for Induction of Foxp3 Expression in the Absence of DNA Methyltransferase 11 , 2009, The Journal of Immunology.

[73]  A. Burny,et al.  Human natural Treg microRNA signature: Role of microRNA‐31 and microRNA‐21 in FOXP3 expression , 2009, European journal of immunology.

[74]  M. A. Curotto de Lafaille,et al.  Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? , 2009, Immunity.

[75]  A. Weiss,et al.  A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity , 2009, The Journal of experimental medicine.

[76]  B. Beutler,et al.  Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery , 2009, PLoS biology.

[77]  B. Kee E and ID proteins branch out , 2009, Nature Reviews Immunology.

[78]  B. Malissen,et al.  Heterogeneity of natural Foxp3+ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity , 2009, Proceedings of the National Academy of Sciences.

[79]  Alf Hamann,et al.  Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? , 2009, Nature Reviews Immunology.

[80]  D. Bartel MicroRNAs: Target Recognition and Regulatory Functions , 2009, Cell.

[81]  Hana Lee,et al.  Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. , 2009, Immunity.

[82]  R. Xavier,et al.  Differential requirement for CARMA1 in agonist‐selected T‐cell development , 2009, European journal of immunology.

[83]  A. Sharpe,et al.  CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity1 , 2009, The Journal of Immunology.

[84]  C. Hsieh,et al.  Antigen-specific peripheral shaping of the natural regulatory T cell population , 2008, The Journal of experimental medicine.

[85]  S. Manicassamy,et al.  Differential requirement of PKC-theta in the development and function of natural regulatory T cells. , 2008, Molecular immunology.

[86]  Matthew S. Hayden,et al.  New regulators of NF-κB in inflammation , 2008, Nature Reviews Immunology.

[87]  T. Nomura,et al.  CTLA-4 Control over Foxp3+ Regulatory T Cell Function , 2008, Science.

[88]  Michael T. McManus,et al.  Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity , 2008, The Journal of experimental medicine.

[89]  W. Schiemann,et al.  Transcriptional and Translational Regulation of TGF-β Production in Response to Apoptotic Cells1 , 2008, The Journal of Immunology.

[90]  A. Rudensky,et al.  Dicer-dependent microRNA pathway safeguards regulatory T cell function , 2008, The Journal of experimental medicine.

[91]  A. Rudensky,et al.  The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease , 2008, The Journal of experimental medicine.

[92]  A. Rudensky,et al.  Differentiation of regulatory Foxp3+ T cells in the thymic cortex , 2008, Proceedings of the National Academy of Sciences.

[93]  B. Lim,et al.  Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression1 , 2008, The Journal of Immunology.

[94]  T. Malek,et al.  A Function for IL-7R for CD4+CD25+Foxp3+ T Regulatory Cells1 , 2008, The Journal of Immunology.

[95]  David K. Finlay,et al.  T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR , 2008, Proceedings of the National Academy of Sciences.

[96]  A. Kulkarni,et al.  A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells , 2008, Nature Immunology.

[97]  S. Zheng,et al.  Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-β Are Resistant to Th17 Conversion by IL-61 , 2008, The Journal of Immunology.

[98]  Yuelei Shen,et al.  TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function , 2008, Nature.

[99]  E. Lamperti,et al.  Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance , 2008, Nature Immunology.

[100]  C. Benoist,et al.  The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells , 2008, The Journal of experimental medicine.

[101]  H. Lodish,et al.  Micromanagement of the immune system by microRNAs , 2008, Nature Reviews Immunology.

[102]  K. Furuuchi,et al.  Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer , 2008, Nature Immunology.

[103]  C. Hsieh,et al.  A two-step process for thymic regulatory T cell development. , 2008, Immunity.

[104]  Y. Zhuang,et al.  Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. , 2007, Immunity.

[105]  Matthew A Burchill,et al.  Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. , 2007, Immunology letters.

[106]  Christophe Benoist,et al.  Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. , 2007, Immunity.

[107]  I. Türbachova,et al.  DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells , 2007, European journal of immunology.

[108]  A. Sharpe,et al.  Induction of autoimmune disease in CTLA-4−/− mice depends on a specific CD28 motif that is required for in vivo costimulation , 2007, Proceedings of the National Academy of Sciences.

[109]  R. Noelle,et al.  All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation , 2007, The Journal of experimental medicine.

[110]  Y. Belkaid,et al.  A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism , 2007, The Journal of experimental medicine.

[111]  Y. Belkaid,et al.  Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid , 2007, The Journal of experimental medicine.

[112]  E. Shevach,et al.  Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. , 2007, Blood.

[113]  Hilde Cheroutre,et al.  Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid , 2007, Science.

[114]  David M Sabatini,et al.  Defining the role of mTOR in cancer. , 2007, Cancer cell.

[115]  A. Pasquinelli,et al.  MicroRNA silencing through RISC recruitment of eIF6 , 2007, Nature.

[116]  A. Rudensky,et al.  Foxp3 in control of the regulatory T cell lineage , 2007, Nature Immunology.

[117]  T. Nomura,et al.  Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 , 2007, Nature.

[118]  E. Shevach,et al.  Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells , 2007, The Journal of Immunology.

[119]  T. Malek,et al.  Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells1 , 2007, The Journal of Immunology.

[120]  L. Hennighausen,et al.  Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. , 2007, Immunity.

[121]  Ximing J. Yang,et al.  Tumor Evasion of the Immune System by Converting CD4+CD25− T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-β , 2007, The Journal of Immunology.

[122]  A. Rudensky,et al.  Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 , 2007, Nature Immunology.

[123]  Ernest Fraenkel,et al.  Foxp3 occupancy and regulation of key target genes during T-cell stimulation , 2007, Nature.

[124]  Vincent C. Manganiello,et al.  Foxp3-dependent programme of regulatory T-cell differentiation , 2007, Nature.

[125]  Y. Wan,et al.  Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression , 2007, Nature.

[126]  Timothy J. Griffin,et al.  Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 , 2007, Nature Cell Biology.

[127]  W. Paul,et al.  Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease , 2007, Proceedings of the National Academy of Sciences.

[128]  F. J. Livesey,et al.  A role for Dicer in immune regulation , 2006, The Journal of experimental medicine.

[129]  S. Akira,et al.  TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. , 2006, International immunology.

[130]  Y. Wan,et al.  The roles for cytokines in the generation and maintenance of regulatory T cells , 2006, Immunological reviews.

[131]  Shimon Sakaguchi,et al.  Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease , 2006, Immunological reviews.

[132]  J. Stroud,et al.  FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT , 2006, Cell.

[133]  Isaac Engel,et al.  Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[134]  Byoung-Tak Zhang,et al.  Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex , 2006, Cell.

[135]  A. Rudensky,et al.  Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[136]  S. Zheng,et al.  TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells1 , 2006, The Journal of Immunology.

[137]  R. Flavell,et al.  Cutting Edge: Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T Cell TGF-β Sensitivity In Vitro and In Vivo , 2006, The Journal of Immunology.

[138]  J. Lohr,et al.  Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen , 2005, The Journal of experimental medicine.

[139]  C. Murre Helix-loop-helix proteins and lymphocyte development , 2005, Nature Immunology.

[140]  M. Nussenzweig,et al.  Inducing and expanding regulatory T cell populations by foreign antigen , 2005, Nature Immunology.

[141]  L. Klein,et al.  Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling , 2005, Nature Immunology.

[142]  A. Rudensky,et al.  A function for interleukin 2 in Foxp3-expressing regulatory T cells , 2005, Nature Immunology.

[143]  A. Rudensky,et al.  Developmental regulation of Foxp3 expression during ontogeny , 2005, The Journal of experimental medicine.

[144]  Michelle M. Sandau,et al.  The timing of TCRα expression critically influences T cell development and selection , 2005, The Journal of experimental medicine.

[145]  M. Battaglia,et al.  Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. , 2005, Blood.

[146]  G. Calabrese,et al.  Deficiency of the Src Homology Region 2 Domain-Containing Phosphatase 1 (SHP-1) Causes Enrichment of CD4+CD25+ Regulatory T Cells1 , 2005, The Journal of Immunology.

[147]  E. Bettelli,et al.  Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[148]  A. Rudensky,et al.  Regulatory T cell lineage specification by the forkhead transcription factor foxp3. , 2005, Immunity.

[149]  H. Schild,et al.  NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells , 2005, The Journal of experimental medicine.

[150]  A. Singer,et al.  CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 , 2005, Nature Immunology.

[151]  N. Sonenberg,et al.  Upstream and downstream of mTOR. , 2004, Genes & development.

[152]  R. Maehr,et al.  Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[153]  S. Sakaguchi Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. , 2004, Annual review of immunology.

[154]  D. Bartel MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[155]  B. Cullen,et al.  Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. , 2003, Genes & development.

[156]  F. Ramsdell,et al.  An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.

[157]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[158]  A. Freitas,et al.  Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers1 , 2002, The Journal of Immunology.

[159]  J. Lafaille,et al.  Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function , 2002, The Journal of experimental medicine.

[160]  T. Malek,et al.  CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. , 2002, Immunity.

[161]  H. Igarashi,et al.  Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. , 2002, Immunity.

[162]  L. Klein,et al.  Origin of regulatory T cells with known specificity for antigen , 2002, Nature Immunology.

[163]  J. Miyazaki,et al.  Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression1 , 2002, The Journal of Immunology.

[164]  C. Murre,et al.  The function of E- and id proteins in lymphocyte development , 2001, Nature Reviews Immunology.

[165]  A. Rudensky,et al.  Dynamic Tuning of T Cell Reactivity by Self-Peptide–Major Histocompatibility Complex Ligands , 2001, The Journal of experimental medicine.

[166]  M. Pfaffl,et al.  A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.

[167]  A. Naji,et al.  Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.

[168]  J. Bluestone,et al.  B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. , 2000, Immunity.

[169]  F. Otsuka,et al.  Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. , 1999, Journal of immunology.

[170]  A. Grinberg,et al.  CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity , 1998, The Journal of experimental medicine.

[171]  E. Shevach,et al.  CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production , 1998, The Journal of experimental medicine.

[172]  V. Fadok,et al.  Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. , 1998, The Journal of clinical investigation.

[173]  P. Allen,et al.  Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands , 1996, The Journal of experimental medicine.

[174]  E. Fuchs,et al.  CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. , 1996, Immunity.

[175]  J. Borst,et al.  CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development , 1996, The Journal of experimental medicine.

[176]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[177]  C. Thompson,et al.  CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. , 1995, Immunity.

[178]  M. Jenkins,et al.  CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. , 1991, Journal of immunology.

[179]  T. Sakakura,et al.  Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice , 1969, Science.

[180]  A. Liston Is foxp3 the master regulator of regulatory T cells? , 2010, Progress in molecular biology and translational science.

[181]  D. Topham,et al.  This information is current as Apoptosis during Influenza Infection Effector T Cells from + Protect Airway CD 8 Integrin and TNF Receptor II 1 β 1 α The , 2007 .

[182]  Ray H. Baughman,et al.  Supporting Online Material , 2003 .

[183]  Mary Collins,et al.  The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. , 2002, Annual review of immunology.

[184]  H. Ochs,et al.  The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 , 2001, Nature Genetics.

[185]  D. Galas,et al.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse , 2001, Nature Genetics.

[186]  Pei-Yun Tsai,et al.  Ar Ticle Identification of an Immediate Foxp3  Precursor to Foxp3 + Regulatory T Cells in Peripheral Lymphoid Organs of Nonmanipulated Mice , 2022 .