Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

[1]  Xiaodong Wang,et al.  DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis , 1997, Cell.

[2]  D. Green,et al.  The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis , 1997, Science.

[3]  Dean P. Jones,et al.  Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.

[4]  G. Núñez,et al.  Interaction and Regulation of Subcellular Localization of CED-4 by CED-9 , 1997, Science.

[5]  A. Chinnaiyan,et al.  Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death , 1997, Science.

[6]  M. Raff,et al.  Programmed Cell Death in Animal Development , 1997, Cell.

[7]  Emad S. Alnemri,et al.  Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis* , 1997, The Journal of Biological Chemistry.

[8]  X. Hua,et al.  Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein , 1996, Cell.

[9]  S. Srinivasula,et al.  The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32* , 1996, The Journal of Biological Chemistry.

[10]  Junying Yuan,et al.  Human ICE/CED-3 Protease Nomenclature , 1996, Cell.

[11]  K. Bhalla,et al.  Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. , 1996, Cancer research.

[12]  E. Alnemri,et al.  Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents. , 1996, Blood.

[13]  G. Cooper,et al.  Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL* , 1996, The Journal of Biological Chemistry.

[14]  H. Horvitz,et al.  An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor , 1996, Cell.

[15]  Xiaodong Wang,et al.  Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c , 1996, Cell.

[16]  S. Korsmeyer,et al.  Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors* , 1996, The Journal of Biological Chemistry.

[17]  H. Horvitz,et al.  The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. , 1996, Genes & development.

[18]  C. Borner,et al.  Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain. , 1996, Biochemical and biophysical research communications.

[19]  Y. Tsujimoto,et al.  Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis. , 1996, Cancer research.

[20]  X. Wang,et al.  Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. , 1996, The EMBO journal.

[21]  A. Chinnaiyan,et al.  Molecular Ordering of the Cell Death Pathway , 1996, The Journal of Biological Chemistry.

[22]  A. Shevchenko,et al.  Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. , 1996, Analytical chemistry.

[23]  H. Horvitz,et al.  Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. , 1996, Genes & development.

[24]  P. Branton,et al.  Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase. , 1996, Oncogene.

[25]  S. Orrenius,et al.  CPP32/Apopain Is a Key Interleukin 1 Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[26]  H. Hamm,et al.  Crystal structure of a G-protein βγ dimer at 2.1 Å resolution , 1996, Nature.

[27]  Andrew Bohm,et al.  Crystal structure of a GA protein βγdimer at 2.1 Å resolution , 1996, Nature.

[28]  S. Sprang,et al.  The structure of the G protein heterotrimer Giα1 β 1 γ 2 , 1995, Cell.

[29]  Patrick R. Griffin,et al.  Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis , 1995, Nature.

[30]  E. Alnemri,et al.  CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. , 1994, The Journal of biological chemistry.

[31]  Raman Nambudripad,et al.  The ancient regulatory-protein family of WD-repeat proteins , 1994, Nature.

[32]  H. Horvitz,et al.  C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2 , 1994, Cell.

[33]  D. Kirsch,et al.  Sequenching of peptides in a time-of-flight mass spectrometer: evaluation of postsource decay following matrix-assisted laser desorption ionisation (MALDI) , 1994 .

[34]  H. Horvitz,et al.  The genetics of programmed cell death in the nematode Caenorhabditis elegans. , 1994, Cold Spring Harbor symposia on quantitative biology.

[35]  Shai Shaham,et al.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme , 1993, Cell.

[36]  A. Admon,et al.  SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene , 1993, Cell.

[37]  D. Ledbetter,et al.  Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats , 1993, Nature.

[38]  C. Watanabe,et al.  Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[39]  H. Horvitz,et al.  The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. , 1992, Development.

[40]  M. Hengartner,et al.  Caenorhabditis elegans gene ced-9 protects cells from programmed cell death , 1992, Nature.

[41]  H. Horvitz,et al.  The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. , 1990, Developmental biology.

[42]  C. Watanabe,et al.  Computer analysis of automated Edman degradation and amino acid analysis data. , 1987, Journal of chromatography.

[43]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[44]  J. Walker,et al.  Distantly related sequences in the alpha‐ and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding fold. , 1982, The EMBO journal.

[45]  A. Wyllie.  Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation , 1980, Nature.

[46]  A. Wyllie,et al.  Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics , 1972, British Journal of Cancer.