Reversing the Outcome of Synapse Elimination at Developing Neuromuscular Junctions In Vivo: Evidence for Synaptic Competition and Its Mechanism

Competition between neurons for the same synaptic sites at the developing neuromuscular junction drives synaptic rearrangements.

[1]  Martin A. Nowak,et al.  Evolutionary dynamics on graphs , 2005, Nature.

[2]  Jeff W. Lichtman,et al.  Multiple innervation of tonic endplates revealed by activity-dependent uptake of fluorescent probes , 1985, Nature.

[3]  J. Sanes,et al.  Development of the vertebrate neuromuscular junction. , 1999, Annual review of neuroscience.

[4]  W. Thompson,et al.  Nerve sprouting in muscle is induced and guided by processes extended by schwann cells , 1995, Neuron.

[5]  J. Schweitzer,et al.  Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[6]  J. Lichtman,et al.  In Vivo Time-Lapse Imaging of Synaptic Takeover Associated with Naturally Occurring Synapse Elimination , 2003, Neuron.

[7]  Jeff W Lichtman,et al.  Chapter 11: Imaging fluorescent mice in vivo using confocal microscopy. , 2008, Methods in cell biology.

[8]  Daniel R. Berger,et al.  Pervasive Synaptic Branch Removal in the Mammalian Neuromuscular System at Birth , 2012, Neuron.

[9]  Q. Yan,et al.  In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons , 1995, Nature.

[10]  J. Trachtenberg,et al.  Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor , 1996, Nature.

[11]  D. Purves,et al.  Regional innervation of rabbit ciliary ganglion cells by the terminals of preganglionic axons , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  J. Lichtman,et al.  Synaptic segregation at the developing neuromuscular junction. , 1998, Science.

[13]  D. Purves,et al.  Elimination of synapses in the developing nervous system. , 1980, Science.

[14]  R R Ribchester,et al.  Persistent polyneuronal innervation in partially denervated rat muscle after reinnervation and recovery from prolonged nerve conduction block , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[15]  Jeff W. Lichtman,et al.  Axon Branch Removal at Developing Synapses by Axosome Shedding , 2004, Neuron.

[16]  R. Ribchester,et al.  A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses , 2005, The European journal of neuroscience.

[17]  R. O'brien,et al.  Observations on the elimination of polyneuronal innervation in developing mammalian skeletal muscle. , 1978, The Journal of physiology.

[18]  G. Feng,et al.  Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP , 2000, Neuron.

[19]  J. W. Lichtman,et al.  Are Neurotrophins Synaptotrophins? , 1996, Molecular and Cellular Neuroscience.

[20]  Mehmet Fatih Yanik,et al.  Neurosurgery: Functional regeneration after laser axotomy , 2004, Nature.

[21]  Jeff W Lichtman,et al.  Rapid Synapse Elimination after Postsynaptic Protein Synthesis Inhibition In Vivo , 2007, The Journal of Neuroscience.

[22]  P. Redfern Neuromuscular transmission in new‐born rats , 1970, The Journal of physiology.

[23]  J. Bixby Ultrastructural observations on synapse elimination in neonatal rabbit skeletal muscle , 1981, Journal of neurocytology.

[24]  H. Clark,et al.  Induction of nerve growth factor receptor in Schwann cells after axotomy. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[25]  J. Sanes,et al.  Pre-existing pathways promote precise projection patterns , 2002, Nature Neuroscience.

[26]  L. Luo,et al.  Axon retraction and degeneration in development and disease. , 2005, Annual review of neuroscience.

[27]  G. Feng,et al.  Glial Cell Line-Derived Neurotrophic Factor Administration in Postnatal Life Results in Motor Unit Enlargement and Continuous Synaptic Remodeling at the Neuromuscular Junction , 2001, The Journal of Neuroscience.

[28]  J. Lichtman,et al.  Synaptic Competition during the Reformation of a Neuromuscular Map , 1998, The Journal of Neuroscience.

[29]  D. V. van Essen,et al.  Polyneuronal innervation of skeletal muscle in new‐born rats and its elimination during maturation. , 1976, The Journal of physiology.

[30]  W. Thompson,et al.  Fibre type composition of single motor units during synapse elimination in neonatal rat soleus muscle , 1984, Nature.

[31]  J. Lichtman,et al.  Interactions between nerve and muscle: synapse elimination at the developing neuromuscular junction. , 1993, Developmental biology.

[32]  N. Kasthuri,et al.  The role of neuronal identity in synaptic competition , 2003, Nature.

[33]  Jeff W. Lichtman,et al.  Long-term synapse loss induced by focal blockade of postsynaptlc receptors , 1994, Nature.

[34]  P. van Mier,et al.  Regenerating muscle fibers induce directional sprouting from nearby nerve terminals: studies in living mice , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[35]  J. Lichtman The reorganization of synaptic connexions in the rat submandibular ganglion during post‐natal development. , 1977, The Journal of physiology.

[36]  C. Henderson,et al.  GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. , 1994, Science.

[37]  G. Feng,et al.  Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition , 2003, Nature.

[38]  J. Jansen,et al.  The extent of sprouting of remaining motor units in partly denervated immature and adult rat soleus muscle , 1977, Neuroscience.

[39]  J. Sanes,et al.  Topographic mapping of motor pools onto skeletal muscles , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[40]  Jeff W Lichtman,et al.  In vivo imaging of axonal degeneration and regeneration in the injured spinal cord , 2005, Nature Medicine.

[41]  J. Lichtman,et al.  Alterations in Synaptic Strength Preceding Axon Withdrawal , 1997, Science.

[42]  R. L. Holland,et al.  Motor nerve sprouting. , 1981, Annual review of neuroscience.

[43]  R. Ribchester,et al.  The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves , 2005, BMC Neuroscience.

[44]  Hyuno Kang,et al.  Terminal Schwann cells guide the reinnervation of muscle after nerve injury , 2003, Journal of neurocytology.

[45]  W. G. Hopkins,et al.  Sprouting of mammalian motorneurones at nodes of ranvier: the role of the denervated motor endplate , 1983, Brain Research.

[46]  G. Feng,et al.  Asynchronous Synapse Elimination in Neonatal Motor Units Studies Using GFP Transgenic Mice , 2001, Neuron.

[47]  Masahiko Watanabe,et al.  Translocation of a “Winner” Climbing Fiber to the Purkinje Cell Dendrite and Subsequent Elimination of “Losers” from the Soma in Developing Cerebellum , 2009, Neuron.

[48]  J. Jansen,et al.  Postnatal loss of synaptic terminals in the partially denervated mouse soleus muscle. , 1987, Acta physiologica Scandinavica.

[49]  L. Chang,et al.  Mitochondrial involvement in the point of no return in neuronal apoptosis. , 2002, Biochimie.

[50]  C. Ko,et al.  Glial Cells Maintain Synaptic Structure and Function and Promote Development of the Neuromuscular Junction In Vivo , 2003, Neuron.