Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice
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U. Schmidt-Erfurth | L. Eckhart | F. Gruber | V. Mlitz | E. Tschachler | Ying-Ting Chen | L. Larue | I. Nagelreiter | H. Rossiter | V. Petit | A. Pollreisz | S. Sukseree | M. Laggner | Maria Laggner | Ying‐Ting Chen
[1] T. Léveillard,et al. Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial Cells , 2016, PloS one.
[2] K. Kaarniranta,et al. Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration , 2016, Progress in Retinal and Eye Research.
[3] W. Hauswirth,et al. Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide , 2016, Investigative ophthalmology & visual science.
[4] M. Komatsu,et al. p62/SQSTM1 functions as a signaling hub and an autophagy adaptor , 2015, The FEBS journal.
[5] D. Lamba,et al. Modeling the Dynamic AMD-Associated Chronic Oxidative Stress Changes in Human ESC and iPSC-Derived RPE Cells. , 2015, Investigative ophthalmology & visual science.
[6] Shaozi Li,et al. Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration , 2015, Cell Death and Disease.
[7] K. Palczewski,et al. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium* , 2015, The Journal of Biological Chemistry.
[8] C. Futter,et al. Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease) , 2015, Human molecular genetics.
[9] S. Mitter,et al. Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium , 2015, Autophagy.
[10] A. J. Roman,et al. Improvement and decline in vision with gene therapy in childhood blindness. , 2015, The New England journal of medicine.
[11] Lorenzo Galluzzi,et al. Metabolic Control of Autophagy , 2014, Cell.
[12] Y. Murakami,et al. Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E , 2014, FEBS open bio.
[13] S. Mitter,et al. Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD , 2014, Autophagy.
[14] K. Kang,et al. miR-410 Inhibition Induces RPE Differentiation of Amniotic Epithelial Stem Cells via Overexpression of OTX2 and RPE65 , 2014, Stem Cell Reviews and Reports.
[15] David S. Williams,et al. The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium , 2014, Molecular Neurobiology.
[16] L. Eckhart,et al. Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation. , 2014, The Journal of investigative dermatology.
[17] J. Handa,et al. p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium. , 2014, Biochimica et biophysica acta.
[18] D. Zack,et al. Transcription Factor SOX9 Plays a Key Role in the Regulation of Visual Cycle Gene Expression in the Retinal Pigment Epithelium* , 2014, The Journal of Biological Chemistry.
[19] J. Handa,et al. Nrf2 signaling is impaired in the aging RPE given an oxidative insult. , 2014, Experimental eye research.
[20] P. Campochiaro,et al. Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling , 2014, Autophagy.
[21] D. Green,et al. Noncanonical Autophagy Promotes the Visual Cycle , 2013, Cell.
[22] A. Salminen,et al. Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells , 2013, PloS one.
[23] D. Green,et al. Noncanonical Autophagy Promotes the Visual Cycle , 2013, Cell.
[24] L. Eckhart,et al. Epidermal keratinocytes form a functional skin barrier in the absence of Atg7 dependent autophagy. , 2013, Journal of dermatological science.
[25] L. Eckhart,et al. Autophagy in epithelial homeostasis and defense. , 2013, Frontiers in bioscience.
[26] L. Punzi,et al. Autophagy in human health and disease. , 2013, The New England journal of medicine.
[27] A. Salminen,et al. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration , 2013, Autophagy.
[28] C. Futter,et al. Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium , 2013, PloS one.
[29] Y. Koutalos,et al. New insights into retinoid metabolism and cycling within the retina , 2013, Progress in Retinal and Eye Research.
[30] M. Mildner,et al. Targeted deletion of Atg5 reveals differential roles of autophagy in keratin K5-expressing epithelia. , 2013, Biochemical and biophysical research communications.
[31] M. Mildner,et al. Autophagy in the Thymic Epithelium Is Dispensable for the Development of Self-Tolerance in a Novel Mouse Model , 2012, PloS one.
[32] Hui Zhao,et al. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. , 2012, Investigative ophthalmology & visual science.
[33] Masaaki Komatsu,et al. Autophagy: Renovation of Cells and Tissues , 2011, Cell.
[34] H. Grossniklaus,et al. Age-Related Retinopathy in NRF2-Deficient Mice , 2011, PloS one.
[35] M. Boulton,et al. Using LC3 to monitor autophagy flux in the retinal pigment epithelium , 2009, Autophagy.
[36] B. Lorenz,et al. A comprehensive clinical and biochemical functional study of a novel RPE65 hypomorphic mutation. , 2008, Investigative ophthalmology & visual science.
[37] D. Bok,et al. Retinal Pigment Epithelium-Retinal G Protein Receptor-Opsin Mediates Light-dependent Translocation of All-trans-retinyl Esters for Synthesis of Visual Chromophore in Retinal Pigment Epithelial Cells* , 2008, Journal of Biological Chemistry.
[38] M. Mildner,et al. Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid. , 2008, Journal of dermatological science.
[39] T Michael Redmond,et al. Effect of Leu/Met variation at residue 450 on isomerase activity and protein expression of RPE65 and its modulation by variation at other residues. , 2007, Molecular vision.
[40] L. Larue,et al. Flanking genomic region of Tyr::Cre mice, rapid genotyping for homozygous mice. , 2007, Pigment cell research.
[41] Masaaki Komatsu,et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice , 2005, The Journal of cell biology.
[42] Ying Chen,et al. RPE65 is the isomerohydrolase in the retinoid visual cycle. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[43] K. Nakanishi,et al. Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[44] L. Larue,et al. SP-14 Cre-mediated recombination in the skin melanocyte lineage , 2003 .
[45] Ulrich Tepass,et al. CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina. , 2003, Human molecular genetics.
[46] M. Pfaffl,et al. A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.
[47] C. Grimm,et al. The Rpe65 Leu450Met Variation Increases Retinal Resistance Against Light-Induced Degeneration by Slowing Rhodopsin Regeneration , 2001, The Journal of Neuroscience.
[48] D. Farber,et al. A QTL on distal Chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors , 2000, Mammalian Genome.
[49] E. Zrenner,et al. Mutations in RPE65 cause Leber's congenital amaurosis , 1997, Nature Genetics.
[50] M. Mildner,et al. Preview : Published ahead of advance online publication Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes , 2014 .
[51] K. Palczewski,et al. Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. , 2009, Investigative ophthalmology & visual science.
[52] Kurt Zatloukal,et al. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. , 2002, The American journal of pathology.