Medicinal, Biological and Pharmacological Aspects of Plumbago zeylanica (Linn.)

The present review deals with chemical compounds, medicinal properties, biological activities and pharmacological effects of Plumbago zeylanica. Plumbago zeylanica (Linn.) belongs to family Plumbaginaceae, commonly known as Chitrak is one of the medicinal plants used in the Indian traditional system of medicine. Traditionally P. zeylanica is used as a stimulant digestant, expectorant, laxative and in the treatment of muscular pain and rheumatic diseases. Some parts of P. zeylanica are used in various pharmacological activities. The different parts of P. zeylanica are used for various ethnomedicinal purposes and investigations have been carried out on different chemical compounds such as plumbagin and other compounds of this plant. Its biological activities like antibacterial, antimycotic, antiviral, antiplasmodial, leishmanicidal, trypanocidal and anticarcinogenic have been studied along with pharmacological effects of it.

[1]  G. Kaushik.  Medicinal Plants: Antibacterial Potential , 2011 .

[2]  R. Vijayakumar,et al.  Plumbago zeylanica action on blood coagulation profile with and without blood volume reduction. , 2006, Vascular pharmacology.

[3]  B. Aggarwal,et al.  Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Suppresses NF-κB Activation and NF-κB-regulated Gene Products Through Modulation of p65 and IκBα Kinase Activation, Leading to Potentiation of Apoptosis Induced by Cytokine and Chemotherapeutic Agents* , 2006, Journal of Biological Chemistry.

[4]  R. Neubert,et al.  Antiviral activities of some Ethiopian medicinal plants used for the treatment of dermatological disorders. , 2006, Journal of ethnopharmacology.

[5]  S. Niranjali Devaraj,et al.  Protective Effect of Plumbago zeylanica Against Cyclophosphamide-Induced Genotoxicity and Oxidative Stress in Swiss Albino Mice , 2006, Drug and chemical toxicology.

[6]  Yuan-Chuen Wang,et al.  Anti-Helicobacter pylori activity of Plumbago zeylanica L. , 2005, FEMS immunology and medical microbiology.

[7]  I. Muhammad,et al.  Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide , 2004, Phytotherapy research : PTR.

[8]  J. Fontaine,et al.  Cytotoxic constituents from Plumbago zeylanica. , 2004, Fitoterapia.

[9]  S. Seth,et al.  Medicinal plants in India. , 2004, The Indian journal of medical research.

[10]  M. A. Kaplan,et al.  PLUMBAGINALES: A PHARMACOLOGICAL APPROACH , 2003 .

[11]  Mukerjee Pk,et al.  Quality control of herbal drugs: an approach to evaluation of botanicals , 2002 .

[12]  U. Nyman,et al.  In vitro screening of Indian medicinal plants for antiplasmodial activity. , 2001, Journal of ethnopharmacology.

[13]  L. Kapoor.  Handbook of Ayurvedic medicinal plants. , 2001 .

[14]  I. Ahmad,et al.  Antimicrobial potency and synergistic activity of five traditionally used Indian medicinal plants. , 2000 .

[15]  P. Kaushik,et al.  Medicinal plants and raw drugs of India , 2000 .

[16]  J. Olagunju,et al.  An investigation into the biochemical basis of the observed hyperglycaemia in rats treated with ethanol root extract of Plumbago zeylanica , 1999, Phytotherapy research : PTR.

[17]  I. Ahmad,et al.  Indian Medicinal Plants: A Potential Source for Anticandidal Drugs , 1999 .

[18]  E. Sausville,et al.  Natural Product Drug Discovery and Development , 1999 .

[19]  O. Oyedapo.  Studies on Bioactivity of the Root Extract of Plumbago zeylanica , 1996 .

[20]  K. Abdul,et al.  Modulatory effect of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) on macrophage functions in BALB/c mice. I. Potentiation of macrophage bactericidal activity. , 1995, Immunopharmacology.

[21]  A. Rojas,et al.  Screening for antimicrobial activity of crude drug extracts and pure natural products from Mexican medicinal plants. , 1992, Journal of ethnopharmacology.

[22]  V. Dixit,et al.  Hypolipidaemic and antiatherosclerotic effects of plumbagin in rabbits. , 1991, Indian journal of physiology and pharmacology.

[23]  P. Sridhar,et al.  Effects of plumbagin on antibiotic resistance in bacteria. , 1990, The Indian journal of medical research.

[24]  M. Krishnaswamy,et al.  Plumbagin: A study of its anticancer, antibacterial & antifungal properties. , 1980, Indian journal of experimental biology.

[25]  R. B. Modi.  A Textbook of Medical Jurisprudence and Toxicology , 1940, The Indian Medical Gazette.

[26]  B. Evers.  Indian Medicinal Plants , 1875, The Indian medical gazette.