Secretion of Natural and Synthetic Toxic Compounds from Filamentous Fungi by Membrane Transporters of the ATP-binding Cassette and Major Facilitator Superfamily

[1]  M. D. Waard,et al.  Differential accumulation of fenarimol by a wild-type isolate and fenarimol-resistant isolates of Penicillium italicum , 1984, Netherlands Journal of Plant Pathology.

[2]  M. D. Waard,et al.  Laboratory resistance to fungicides which inhibit ergosterol biosynthesis in Penicillium italicum , 1982, Netherlands Journal of Plant Pathology.

[3]  J. A. Gorman,et al.  Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate , 1991, Molecular and General Genetics MGG.

[4]  P. A. Rea,et al.  The GSX Pump in Plant , Yeast , and Animal Cells : Structure , Function , and Gene Expression , 2003 .

[5]  H. Schoonbeek,et al.  Bcmfs1, a Novel Major Facilitator Superfamily Transporter from Botrytis cinerea, Provides Tolerance towards the Natural Toxic Compounds Camptothecin and Cercosporin and towards Fungicides , 2002, Applied and Environmental Microbiology.

[6]  K. Venema,et al.  Molecular cloning and characterisation of three new ATP-binding cassette transporter genes from the wheat pathogen Mycosphaerella graminicola. , 2002, Gene.

[7]  H. Hamamoto,et al.  A novel ABC transporter gene, PMR5, is involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum , 2002, Molecular Genetics and Genomics.

[8]  A. Fleissner,et al.  An ATP-binding cassette multidrug-resistance transporter is necessary for tolerance of Gibberella pulicaris to phytoalexins and virulence on potato tubers. , 2002, Molecular plant-microbe interactions : MPMI.

[9]  C. Avendaño,et al.  Inhibitors of multidrug resistance to antitumor agents (MDR). , 2002, Current medicinal chemistry.

[10]  R. Upchurch,et al.  Over-expression of the cercosporin facilitator protein, CFP, in Cercospora kikuchii up-regulates production and secretion of cercosporin. , 2001, FEMS microbiology letters.

[11]  J. Lopez-Ribot,et al.  Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients , 2001, Antimicrobial Agents and Chemotherapy.

[12]  T. Hibi,et al.  Functional Analysis of an ATP-Binding Cassette Transporter Gene in Botrytis cinerea by Gene Disruption , 2001, Journal of General Plant Pathology.

[13]  B. Turgeon,et al.  Fungal genomics and pathogenicity. , 2001, Current opinion in plant biology.

[14]  H. Schoonbeek,et al.  Multidrug resistance in Botrytis cinerea associated with decreased accumulation of the azole fungicide oxpoconazole and increased transcription of the ABC transporter gene BcatrD , 2001 .

[15]  B. Tudzynski,et al.  A new MFS-transporter gene next to the gibberellin biosynthesis gene cluster of Gibberella fujikuroi is not involved in gibberellin secretion , 2001, Current Genetics.

[16]  H. Schoonbeek,et al.  The ABC transporter BcatrB from Botrytis cinerea is a determinant of the activity of the phenylpyrrole fungicide fludioxonil. , 2001, Pest management science.

[17]  K. Kuchler,et al.  Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification. , 2001, Research in microbiology.

[18]  H. Schoonbeek,et al.  The ABC transporter BcatrB affects the sensitivity of Botrytis cinerea to the phytoalexin resveratrol and the fungicide fenpiclonil. , 2001, Molecular plant-microbe interactions : MPMI.

[19]  Mccormick,et al.  Transgenic expression of the TRI101 or PDR5 gene increases resistance of tobacco to the phytotoxic effects of the trichothecene 4,15-diacetoxyscirpenol. , 2000, Plant science : an international journal of experimental plant biology.

[20]  H. Hamamoto,et al.  Tandem Repeat of a Transcriptional Enhancer Upstream of the Sterol 14α-Demethylase Gene (CYP51) inPenicillium digitatum , 2000, Applied and Environmental Microbiology.

[21]  A. C. Andrade,et al.  The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds. , 2000, Microbiology.

[22]  L. Zwiers,et al.  Characterization of the ABC transporter genes MgAtr1 and MgAtr2 from the wheat pathogen Mycosphaerella graminicola. , 2000, Fungal genetics and biology : FG & B.

[23]  P. Skatrud,et al.  The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production , 2000, Molecular and General Genetics MGG.

[24]  H. Schoonbeek,et al.  Fungal transporters involved in efflux of natural toxic compounds and fungicides. , 2000, Fungal genetics and biology : FG & B.

[25]  F. Theodoulou Plant ABC transporters. , 2000, Biochimica et biophysica acta.

[26]  A. C. Andrade ABC transporters and multidrug resistance in Aspergillus nidulans , 2000 .

[27]  V. St. Georgiev Membrane transporters and antifungal drug resistance. , 2000, Current drug targets.

[28]  K. Kuchler,et al.  Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. , 1999, Biochimica et biophysica acta.

[29]  R. Upchurch,et al.  CFP, the putative cercosporin transporter of Cercospora kikuchii, is required for wild type cercosporin production, resistance, and virulence on soybean. , 1999, Molecular plant-microbe interactions : MPMI.

[30]  K. Venema,et al.  ABC transporters in the wheat pathogen Mycosphaerella graminicola , 1999 .

[31]  S. McCormick,et al.  TRI12, a trichothecene efflux pump from Fusarium sporotrichioides: gene isolation and expression in yeast , 1999, Molecular and General Genetics MGG.

[32]  Jiujiang Yu,et al.  The Carboxy-Terminal Portion of the Aflatoxin Pathway Regulatory Protein AFLR of Aspergillus parasiticus ActivatesGAL1::lacZ Gene Expression inSaccharomyces cerevisiae , 1999, Applied and Environmental Microbiology.

[33]  I. Pastan,et al.  Biochemical, cellular, and pharmacological aspects of the multidrug transporter. , 1999, Annual review of pharmacology and toxicology.

[34]  J. Hamer,et al.  An ATP‐driven efflux pump is a novel pathogenicity factor in rice blast disease , 1999, The EMBO journal.

[35]  D. Kelly,et al.  Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains , 1998, Antimicrobial Agents and Chemotherapy.

[36]  M. Tomiyama,et al.  A Novel ATP-Binding Cassette Transporter Involved in Multidrug Resistance in the Phytopathogenic FungusPenicillium digitatum , 1998, Applied and Environmental Microbiology.

[37]  I. Paulsen,et al.  Major Facilitator Superfamily , 1998, Microbiology and Molecular Biology Reviews.

[38]  I. Paulsen,et al.  Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  D. Taglicht,et al.  Saccharomyces cerevisiae ABC proteins and their relevance to human health and disease. , 1998, Methods in enzymology.

[40]  F. Dromer,et al.  Antifungal drug resistance in pathogenic fungi. , 1998, Medical mycology.

[41]  M. D. Waard Significance of ABC transporters in fungicide sensitivity and resistance. , 1997 .

[42]  P. Skatrud,et al.  Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus. , 1997, Gene.

[43]  Rupert De Wachter,et al.  Classification of all putative permeases and other membrane multispanners of the Major Facilitator Superfamily encoded by the complete genome of Saccharomyces cerevisiae , 1997, German Conference on Bioinformatics.

[44]  P. E. Russell,et al.  Modern Fungicides and Antifungal Compounds , 1997 .

[45]  T. C. White,et al.  Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus , 1997, Antimicrobial agents and chemotherapy.

[46]  T. Massey,et al.  ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene. , 1997, Molecular pharmacology.

[47]  O. Nielsen,et al.  The Schizosaccharomyces pombe mam1 gene encodes an ABC transporter mediating secretion of M-factor , 1997, Molecular and General Genetics MGG.

[48]  S. Kelly,et al.  Itraconazole resistance in Aspergillus fumigatus , 1997, Antimicrobial agents and chemotherapy.

[49]  E. Balzi,et al.  Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters , 1997, Molecular and General Genetics MGG.

[50]  C. Higgins,et al.  Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis* , 1997, The Journal of Biological Chemistry.

[51]  P. A. Rea,et al.  The GS-X Pump in Plant, Yeast, and Animal Cells: Structure, Function, and Gene Expression , 1997, Bioscience reports.

[52]  G. Tusnády,et al.  Membrane topology distinguishes a subfamily of the ATP‐binding cassette (ABC) transporters , 1997, FEBS letters.

[53]  André Goffeau,et al.  Complete inventory of the yeast ABC proteins , 1997, Nature Genetics.

[54]  D. Sanglard,et al.  Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. , 1997, Microbiology.

[55]  H. Rosenberg,et al.  Intronic Enhancer Activity of the Eosinophil-derived Neurotoxin (RNS2) and Eosinophil Cationic Protein (RNS3) Genes Is Mediated by an NFAT-1 Consensus Binding Sequence* , 1997, The Journal of Biological Chemistry.

[56]  P. Roepe,et al.  Biophysical aspects of P-glycoprotein-mediated multidrug resistance. , 1997, International review of cytology.

[57]  I. Paulsen,et al.  Proton-dependent multidrug efflux systems , 1996, Microbiological reviews.

[58]  R. Cannon,et al.  Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance , 1996, Antimicrobial agents and chemotherapy.

[59]  I. Bosch,et al.  P-glycoprotein multidrug resistance and cancer. , 1996, Biochimica et biophysica acta.

[60]  J. Walton,et al.  A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum. , 1996, Microbiology.

[61]  G. Bai,et al.  Reduced virulence of trichothecene-nonproducing mutants of Gibberella zeae in wheat field tests , 1996 .

[62]  J. Kan,et al.  Multidrug resistance in filamentous fungi. , 1996 .

[63]  M. Shaw,et al.  Histology of the pathogenesis of Mycosphaerella graminicola in wheat , 1996 .

[64]  D. Loo,et al.  Kinetics of Steady-state Currents and Charge Movements Associated with the Rat Na+/Glucose Cotransporter (*) , 1995, The Journal of Biological Chemistry.

[65]  K. Kuchler,et al.  Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters , 1995, Antimicrobial agents and chemotherapy.

[66]  D. Clarke,et al.  Covalent Modification of Human P-glycoprotein Mutants Containing a Single Cysteine in Either Nucleotide-binding Fold Abolishes Drug-stimulated ATPase Activity (*) , 1995, The Journal of Biological Chemistry.

[67]  L. Greenberger,et al.  Functional Evidence That Transmembrane 12 and the Loop between Transmembrane 11 and 12 Form Part of the Drug-binding Domain in P-glycoprotein Encoded by MDR1 (*) , 1995, The Journal of Biological Chemistry.

[68]  P. Marichal,et al.  Mechanisms of resistance to azole antifungals. , 1995, Acta biochimica Polonica.

[69]  P. Roepe Drug transport mediated by P-glycoprotein may be secondary to electrochemical perturbations of the plasma membrane , 1994 .

[70]  D. Clarke,et al.  Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides. , 1994, The Journal of biological chemistry.

[71]  K. Kuchler,et al.  Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. , 1994, The Journal of biological chemistry.

[72]  P. Roepe Indirect mechanism of drug transport by P-glycoprotein. , 1994, Trends in pharmacological sciences.

[73]  P. Henderson,et al.  The 12-transmembrane helix transporters. , 1993, Current opinion in cell biology.

[74]  L. Greenberger,et al.  Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12. , 1993, The Journal of biological chemistry.

[75]  A. E. Senior,et al.  Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein. , 1993, The Journal of biological chemistry.

[76]  I. Paulsen,et al.  Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes--an analysis. , 1993, Gene.

[77]  I. Pastan,et al.  Biochemistry of multidrug resistance mediated by the multidrug transporter. , 1993, Annual review of biochemistry.

[78]  M. Saier,et al.  A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. , 1993, Trends in biochemical sciences.

[79]  S. Amara,et al.  Families of twelve transmembrane domain transporters. , 1992, Current opinion in biotechnology.

[80]  T. Ishikawa,et al.  The ATP-dependent glutathione S-conjugate export pump. , 1992, Trends in biochemical sciences.

[81]  C. Higgins,et al.  ABC transporters: from microorganisms to man. , 1992, Annual review of cell biology.

[82]  I. Pastan,et al.  Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[83]  I. Paulsen,et al.  Membrane transport proteins: implications of sequence comparisons. , 1992, Current opinion in cell biology.

[84]  M. Gottesman,et al.  Is the multidrug transporter a flippase? , 1992, Trends in biochemical sciences.

[85]  I. Roninson,et al.  Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[86]  I. Pastan,et al.  Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. , 1990, The Journal of biological chemistry.

[87]  R. Heinrikson,et al.  Gene duplication in the evolution of the two complementing domains of gram-negative bacterial tetracycline efflux proteins. , 1990, Gene.

[88]  J. Thorner,et al.  Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells. , 1989, The EMBO journal.

[89]  M. Azzaria,et al.  Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance , 1989, Molecular and cellular biology.

[90]  K. Nikaido,et al.  Reconstitution of periplasmic transport in inside-out membrane vesicles. Energization by ATP. , 1989, The Journal of biological chemistry.

[91]  I. Pastan,et al.  The multidrug transporter, a double-edged sword. , 1988, The Journal of biological chemistry.

[92]  M. D. Waard,et al.  Accumulation of SBI fungicides in wild-type and fenarimol-resistant isolates of Penicillium italicum , 1988 .

[93]  M. D. Waard,et al.  Effects of phthalimide fungicides on the accumulation of fenarimol by Aspergillus nidulans , 1984 .

[94]  J. Walker,et al.  Distantly related sequences in the alpha‐ and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding fold. , 1982, The EMBO journal.

[95]  M. D. Waard,et al.  Antagonistic and synergistic activities of various chemicalson the toxicity of fenarimol to Aspergillus nidulans , 1982 .

[96]  M. D. Waard,et al.  An energy-dependent efflux mechanism for fenarimol in a wild-type strain and fenarimol-resistant mutants of Aspergillus nidulans , 1980 .

[97]  R L Juliano,et al.  A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. , 1976, Biochimica et biophysica acta.

[98]  I. Leopold,et al.  Pharmacology and toxicology. , 1951, A.M.A. archives of ophthalmology.