Effects of oral caffeine pretreatment on response to intravenous nicotine and cocaine.

Previous research suggests that under conditions of chronic daily caffeine administration, caffeine increases the effects of nicotine. Little is known about the effects of caffeine pretreatment on response to nicotine under infrequent caffeine administration conditions. The present study examined whether infrequent (not on consecutive days) acute oral caffeine administration alters subject-rated, physiological, and monetary value effects of intravenous nicotine in regular users of caffeine, tobacco, and cocaine. To determine the specificity of effects of caffeine on response to nicotine, the effects of caffeine administration on response to intravenous cocaine (another short-acting stimulant) were also studied. Fourteen (1 woman) volunteers participated in this 3-4 week, double-blind, inpatient study. Volunteers participated in 10 experimental conditions in pseudo-randomized order, in which oral caffeine (250 mg/70 kg) or placebo was administered 1 hr before an intravenous injection, consisting of nicotine (1 or 2 mg/70 kg), cocaine (15 or 30 mg/70 kg), or saline. Infrequent acute caffeine pretreatment attenuated the increase resulting from 2 mg/70 kg nicotine administration on ratings of "rush," "good effects," "liking," "high," and "drowsy/sleepy." Caffeine had no significant effect on physiological response to nicotine. Caffeine had no significant effect on subject-rated and physiological response to cocaine, with the exception that caffeine significantly augmented blood pressure response to cocaine. In contrast to the previous research using chronic caffeine maintenance, these data suggest that infrequent acute caffeine administration may attenuate nicotine effects.

[1]  S. Goldberg,et al.  Effects of chronic caffeine exposure on adenosinergic modulation of the discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats , 2009, Psychopharmacology.

[2]  S. Ferré.  An update on the mechanisms of the psychostimulant effects of caffeine , 2008, Journal of neurochemistry.

[3]  J. Jennings,et al.  Caffeine's influence on nicotine's effects in nonsmokers. , 2007, American journal of health behavior.

[4]  K. Perkins,et al.  The influence of caffeine on nicotine's discriminative stimulus, subjective, and reinforcing effects. , 2005, Experimental and clinical psychopharmacology.

[5]  F. Ciruela,et al.  Adenosine receptor‐mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N‐methyl‐d‐aspartate receptor stimulation , 2004, Journal of neurochemistry.

[6]  R. Griffiths,et al.  Transdermal Nicotine Maintenance Attenuates the Subjective and Reinforcing Effects of Intravenous Nicotine, but not Cocaine or Caffeine, in Cigarette-Smoking Stimulant Abusers , 2004, Neuropsychopharmacology.

[7]  S. Heishman,et al.  Nicotine serves as an effective reinforcer of intravenous drug-taking behavior in human cigarette smokers , 2004, Psychopharmacology.

[8]  Katerina Antoniou,et al.  Involvement of Adenosine A1 and A2A Receptors in the Motor Effects of Caffeine after its Acute and Chronic Administration , 2003, Neuropsychopharmacology.

[9]  R. Bevins,et al.  Effects of chronic caffeine pre-exposure on conditioned and unconditioned psychomotor activity induced by nicotine and amphetamine in rats , 2003, Behavioural pharmacology.

[10]  S. Goldberg,et al.  Caffeine potentiates the discriminative-stimulus effects of nicotine in rats , 2002, Psychopharmacology.

[11]  R. Bevins,et al.  Chronic caffeine exposure in rats blocks a subsequent nicotine-conditioned taste avoidance in a one-bottle, but not a two-bottle test , 2001, Pharmacology Biochemistry and Behavior.

[12]  H. Jones,et al.  Physiological, subjective and reinforcing effects of oral and intravenous cocaine in humans , 2001, Psychopharmacology.

[13]  M. Jarvis,et al.  Nicotine yield from machine-smoked cigarettes and nicotine intakes in smokers: evidence from a representative population survey. , 2001, Journal of the National Cancer Institute.

[14]  S. Goldberg,et al.  Changes in the ambulatory activity and discriminative stimulus effects of psychostimulant drugs in rats chronically exposed to caffeine: effect of caffeine dose. , 2000, The Journal of pharmacology and experimental therapeutics.

[15]  S. Goldberg,et al.  Chronic caffeine exposure potentiates nicotine self-administration in rats , 1999, Psychopharmacology.

[16]  S. Goldberg,et al.  Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine. , 1999, The Journal of pharmacology and experimental therapeutics.

[17]  S. Goldberg,et al.  Behavioral effects of nicotine, amphetamine and cocaine under a fixed-interval schedule of food reinforcement in rats chronically exposed to caffeine , 1998, Psychopharmacology.

[18]  T. Duka,et al.  Discriminative stimulus properties of nicotine at low doses: the effects of caffeine preload. , 1998, Behavioural pharmacology.

[19]  M. Carroll,et al.  Dietary additives and the acquisition of cocaine self-administration in rats , 1998, Psychopharmacology.

[20]  S. Comer,et al.  Oral caffeine pretreatment produced modest increases in smoked cocaine self-administration in rhesus monkeys , 1996, Psychopharmacology.

[21]  R. Griffiths,et al.  Validation of the Multiple-Choice procedure for investigating drug reinforcement in humans , 1996 .

[22]  J. D. Lane.  Association of coffee drinking with cigarette smoking in the natural environment , 1996 .

[23]  R. Griffiths,et al.  Intravenous caffeine in stimulant drug abusers: subjective reports and physiological effects. , 1995, The Journal of pharmacology and experimental therapeutics.

[24]  R. Griffiths,et al.  Abecarnil and alprazolam in humans: behavioral, subjective and reinforcing effects. , 1995, The Journal of pharmacology and experimental therapeutics.

[25]  J. Rose,et al.  Effects of daily caffeine intake on smoking behavior in the natural environment. , 1995 .

[26]  S. Schenk,et al.  Reinstatement of extinguished cocaine-taking behavior by cocaine and caffeine , 1994, Pharmacology Biochemistry and Behavior.

[27]  J. A. Swanson,et al.  Caffeine and nicotine: a review of their joint use and possible interactive effects in tobacco withdrawal. , 1994, Addictive behaviors.

[28]  RR. Griffiths,et al.  Multiple‐choice procedure: an efficient approach for investigating drug reinforcement in humans , 1993, Behavioural pharmacology.

[29]  W. Bickel,et al.  Behavioral economics of drug self-administration , 1992, Psychopharmacology.

[30]  L. Kozlowski,et al.  The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. , 1991, British journal of addiction.

[31]  K. Bättig,et al.  Effects of nicotine, caffeine, and their combination on locomotor activity in rats , 1991, Pharmacology Biochemistry and Behavior.

[32]  J. Rose,et al.  Psychophysiological interactions between caffeine and nicotine , 1991, Pharmacology Biochemistry and Behavior.

[33]  Roland R. Griffiths,et al.  Reinforcing effects of caffeine in humans , 1988, Pharmacology Biochemistry and Behavior.

[34]  Y. Tang,et al.  Differential biochemical mechanisms mediate locomotor stimulation effects by caffeine and nicotine in rats , 1987, Pharmacology Biochemistry and Behavior.

[35]  J. Matarazzo,et al.  Tobacco, alcohol, and caffeine use: a review of their interrelationships. , 1984, Psychological bulletin.

[36]  S. Goldberg,et al.  Control of behavior by intravenous nicotine injections in human subjects , 1983, Pharmacology Biochemistry and Behavior.

[37]  R. Griffiths,et al.  Effects of caffeine on cigarette smoking and subjective response , 1983, Clinical pharmacology and therapeutics.

[38]  L. Kozlowski.  Effects of caffeine consumption on nicotine consumption , 1976, Psychopharmacology.

[39]  F. Ciruela,et al.  Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain. , 2008, Frontiers in bioscience : a journal and virtual library.

[40]  K. Perkins,et al.  Subjective and cardiovascular responses to nicotine combined with caffeine during rest and casual activity , 2005, Psychopharmacology.

[41]  H. Jones,et al.  Oral caffeine maintenance potentiates the reinforcing and stimulant subjective effects of intravenous nicotine in cigarette smokers , 2002, Psychopharmacology.

[42]  H. Jones,et al.  Subjective and physiological effects of intravenous nicotine and cocaine in cigarette smoking cocaine abusers. , 1999, The Journal of pharmacology and experimental therapeutics.

[43]  R. Griffiths,et al.  Caffeine reinforcement: the role of withdrawal , 1997, Psychopharmacology.

[44]  B. T. Davies,et al.  Caffeine exposure sensitizes rats to the reinforcing effects of cocaine. , 1991, Neuroreport.

[45]  C. Cohen,et al.  Behavioral Interaction Between Nicotine and Caffeine , 1991 .

[46]  J. Rose.  Cigarette smoking blocks caffeine-induced arousal. , 1987, Alcohol and drug research.

[47]  H. Emurian,et al.  Event time-series relationship between cigarette smoking and coffee drinking. , 1982, Addictive behaviors.

[48]  L. Epstein,et al.  Relative effects of nicotine and coffee on cigarette smoking. , 1981, Addictive behaviors.

[49]  L. Epstein,et al.  Coffee drinking and cigarette smoking: I. Coffee, caffeine and cigarette smoking behavior. , 1980, Addictive behaviors.