Low-dose tissue plasminogen activator for calciphylaxis.

A).Theulcerationprogressedinspiteofmul-tipletreatmentselsewherethatincludedintensivewoundcarewithwet-to-drydressings,topicalbecaplermin,sur-gical debridement, and Unna boot dressings. A skin bi-opsyspecimendemonstratedintravascularandextravas-cular calcification with pannicular necrosis and fibrinthrombi in dermal blood vessels consistent with calci-phylaxis (

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