ASPIRATION PNEUMONITIS PROPHYLAXIS IN OBSTETRIC ANAESTHESIA: COMPARISON OF EFFERVESCENT CIMETIDINE-SODIUM CITRATE MIXTURE AND SODIUM CITRATE

SUMMARY One hundred and forty-seven patients undergoing elective or emergency Caesarean section under general anaesthesia were allocated randomly to three groups: group 1 (n = 28) received no premedication; group 2 (n = 58) received 0.3-molar sodium citrate 15 ml (sodium citrate 1.16 g); group 3 (n = 61) received effervescent cimetidine-sodium citrate combination (cimetidine 400 mg with sodium citrate 0.9 g) after entering the operating room. Gastric pH was measured at tracheal intubation (pH1) and extubation (pH2). Mean pH1 and mean pH2 values in group 1 were, respectively, 2.25 (SD 1.35) and 2.83 (1.64). Mean pH1 and pH2 values in group 2 were, respectively, 4.38 (1.44) and 4.57 (1.51). In group 3 mean pH1 and pH2 values were, respectively, 5.07 (1.13) and 5.37 (1.30). Percentages of patients with pH1

[1]  M. Ganansia,et al.  ASPIRATION PNEUMONIA PROPHYLAXIS - USE OF ORAL EFFERVESCENT CIMETIDINE IN OBSTETRIC ANESTHESIA , 1988 .

[2]  R. Bullingham,et al.  Noninvasive Assessment by Radiotelemetry of Antacid Effect during Labor , 1985, Anesthesia and analgesia.

[3]  T. Bogard,et al.  Sodium Citrate Pretreatment in Elective Cesarean Section Patients , 1985, Anesthesia and analgesia.

[4]  O'Sullivan Gm,et al.  Does twice the volume of antacid have twice the effect in pregnant women at term , 1984 .

[5]  J. Modell,et al.  Pulmonary aspiration--effects of volume and pH in the rat. , 1984 .

[6]  W. Nimmo.  Effect of anaesthesia on gastric motility and emptying. , 1984, British journal of anaesthesia.

[7]  L. Manchikanti,et al.  Cimetidine and Related Drugs in Anesthesia , 1982, Anesthesia and analgesia.

[8]  C. Gibbs,et al.  The effectiveness of sodium citrate as an antacid. , 1982, Anesthesiology.

[9]  J. Saunders,et al.  Sodium Citrate: An Alternative Antacid for Prophylaxis against Aspiration Pneumonitis , 1982, Anaesthesia and intensive care.

[10]  L. Jenkins,et al.  A comparative evaluation of cimetidine and sodium citrate to decrease gastric acidity: Effectiveness at the time of induction of anaesthesia , 1981, Canadian Anaesthetists' Society journal.

[11]  R. Ravindran,et al.  Gastric Fluid pH in Patients Receiving Sodium Citrate , 1981, Anesthesia and analgesia.

[12]  W. J. Westlake,et al.  Bioavailability of cimetidine in man , 1978 .

[13]  M. Shirley,et al.  Reducing the Risk of Acid Aspiration During Cesarean Section , 1974, Anesthesia and analgesia.

[14]  S. Lahiri,et al.  Single-dose antacid therapy for the prevention of Mendelson's syndrome. , 1973, British journal of anaesthesia.

[15]  A. Adelstein,et al.  Report on confidential enquiries into maternal deaths in England and Wales 1967-1969. , 1972, Reports on health and social subjects.

[16]  C. L. Mendelson.  The aspiration of stomach contents into the lungs during obstetric anesthesia. , 1946, American journal of obstetrics and gynecology.