Acute Renal Failure due to IgM-λ Glomerular Thrombi and MPGN-Like Lesions in a Patient With Angioimmunoblastic T-Cell Lymphoma

A 70-year-old man with angioimmunoblastic T-cell lymphoma developed acute renal failure. Laboratory data showed decreased levels of serum C3, C4, and CH50, elevated immunoglobulin M (IgM) levels, and the presence of cryoglobulinemia (IgM-λ). Renal biopsy showed membranoproliferative glomerulonephritis–like lesions with azan-red–stained thrombi in the glomerular capillary lumen. Immunofluorescence showed that IgM-λ stained strongly in the glomerular capillary lumen, equal to the azan-red–stained thrombi, whereas C3 and C4 staining was negative. Electron microscopy showed electron-dense deposits in the subendothelial space and glomerular thrombi lacking fine fibrillar structure. These findings suggest that cryoglobulin, which consists of monoclonal IgM-λ, induced glomerular thrombi and acute renal failure in a patient with angioimmunoblastic T-cell lymphoma.

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