Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive.

[1]  P. Jeggo,et al.  Identification of a DNA Nonhomologous End-Joining Complex in Bacteria , 2002, Science.

[2]  D. Ramsden,et al.  Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair , 2002, Molecular and Cellular Biology.

[3]  S. West,et al.  Involvement of human polynucleotide kinase in double‐strand break repair by non‐homologous end joining , 2002, The EMBO journal.

[4]  M. Gellert V(D)J recombination: RAG proteins, repair factors, and regulation. , 2002, Annual review of biochemistry.

[5]  L. Chin,et al.  Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. , 2001, Molecular cell.

[6]  B. L. Sibanda,et al.  Crystal structure of an Xrcc4–DNA ligase IV complex , 2001, Nature Structural Biology.

[7]  M. Gellert,et al.  Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[8]  A. Fischer,et al.  Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency , 2001, Cell.

[9]  J. Hoeijmakers,et al.  Chromosomal stability and the DNA double-stranded break connection , 2001, Nature Reviews Genetics.

[10]  R. Ghirlando,et al.  Crystal structure of the Xrcc4 DNA repair protein and implications for end joining , 2000, The EMBO journal.

[11]  Kyung-Jong Lee,et al.  DNA Ligase IV and XRCC4 Form a Stable Mixed Tetramer That Functions Synergistically with Other Repair Factors in a Cell-free End-joining System* , 2000, The Journal of Biological Chemistry.

[12]  F. Alt,et al.  Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development , 2000, Nature.

[13]  S. Jackson,et al.  Ku, a DNA repair protein with multiple cellular functions? , 1999, Mutation research.

[14]  M. Gellert,et al.  DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity , 1999, The EMBO journal.

[15]  M. Lieber The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes , 1999, Genes to cells : devoted to molecular & cellular mechanisms.

[16]  T. Stamato,et al.  Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. , 1999, Mutation research.

[17]  D. Barnes,et al.  Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice , 1998, Current Biology.

[18]  F. Alt,et al.  A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis , 1998, Cell.

[19]  F. Alt,et al.  Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV , 1998, Nature.

[20]  M. Sternberg,et al.  Structure of an XRCC1 BRCT domain: a new protein–protein interaction module , 1998, The EMBO journal.

[21]  K. Schwarz,et al.  DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. , 1998, Molecular cell.

[22]  S. Jackson,et al.  DNA end-joining: from yeast to man. , 1998, Trends in biochemical sciences.

[23]  M. Lieber,et al.  Requirement for an Interaction of XRCC4 with DNA Ligase IV for Wild-type V(D)J Recombination and DNA Double-strand Break Repairin Vivo * , 1998, The Journal of Biological Chemistry.

[24]  Y. Yamaguchi-Iwai,et al.  Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells , 1998, The EMBO journal.

[25]  B. Wickstead,et al.  Role of a BRCT domain in the interaction of DNA ligase III-α with the DNA repair protein XRCC1 , 1998, Current Biology.

[26]  F. Alt,et al.  Molecular genetic characterization of XRCC4 function. , 1997, International immunology.

[27]  S. Jackson,et al.  Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV , 1997, Current Biology.

[28]  M. Lieber,et al.  Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells , 1997, Nature.

[29]  J. Hoeijmakers,et al.  Disruption of Mouse RAD54 Reduces Ionizing Radiation Resistance and Homologous Recombination , 1997, Cell.

[30]  D. Schatz,et al.  RAG1 and RAG2 Form a Stable Postcleavage Synaptic Complex with DNA Containing Signal Ends in V(D)J Recombination , 1997, Cell.

[31]  J. Mornon,et al.  From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair , 1997, FEBS letters.

[32]  T. Lindahl,et al.  DNA Ligase IV from HeLa Cell Nuclei* , 1996, The Journal of Biological Chemistry.

[33]  F. Alt,et al.  The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination , 1995, Cell.

[34]  D. Barnes,et al.  Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination , 1995, Molecular and cellular biology.

[35]  J E Hesse,et al.  Expression and V(D)J recombination activity of mutated RAG-1 proteins. , 1994, Nucleic acids research.

[36]  F. Alt,et al.  Impairment of V(D)J recombination in double-strand break repair mutants. , 1993, Science.

[37]  J. Dixon,et al.  Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. , 1991, Analytical biochemistry.

[38]  Stephen J. Perkins,et al.  Protein volumes and hydration effects , 1986 .

[39]  A. Giaccia,et al.  Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell , 1983, Somatic cell genetics.