Preclinical evaluation of lovastatin.

[1]  I. Chen,et al.  The physiological disposition of lovastatin. , 1989, Drug metabolism and disposition: the biological fate of chemicals.

[2]  J. Tobert.  Efficacy and long-term adverse effect pattern of lovastatin. , 1988, The American journal of cardiology.

[3]  A. Alberts,et al.  Discovery, biochemistry and biology of lovastatin. , 1988, The American journal of cardiology.

[4]  A. Alberts,et al.  Brain and optic system pathology in hypocholesterolemic dogs treated with a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. , 1988, The American journal of pathology.

[5]  I. Singer,et al.  Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[6]  D. Gordon,et al.  3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: a new class of cholesterol-lowering agents. , 1987, Annals of internal medicine.

[7]  H. Brewer,et al.  Testicular function in type II hyperlipoproteinemic patients treated with lovastatin (mevinolin) or neomycin. , 1987, Journal of Clinical Endocrinology and Metabolism.

[8]  S. Fukushima,et al.  Dose response in butylated hydroxyanisole induction of forestomach carcinogenesis in F344 rats. , 1986, Journal of the National Cancer Institute.

[9]  A. Alberts,et al.  Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[10]  F P Perera,et al.  The genotoxic/epigenetic distinction: relevance to cancer policy. , 1984, Environmental research.

[11]  R. Robertson,et al.  Mevalonate supplementation in pregnant rats suppresses the teratogenicity of mevinolinic acid, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase. , 1983, Teratology.

[12]  G. Williams.  Epignetic effects of liver tumor promoters and implications for health effects , 1983, Environmental health perspectives.

[13]  I. J. Pachter,et al.  An Analysis of the Carcinogenesis Testing Experience of the National Cancer Institute , 1982 .

[14]  M. Brown,et al.  Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. , 1980, Journal of lipid research.

[15]  J. Jancar.  ANTICONVULSANT DRUGS AND CANCER , 1980, The Lancet.

[16]  Endo Akira,et al.  Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals , 1979 .

[17]  M. Wiley,et al.  Essential role for mevalonate synthesis in DNA replication. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[18]  S. White,et al.  ANTICONVULSANT DRUGS AND CANCER A Cohort Study in Patients with Severe Epilepsy , 1979, The Lancet.

[19]  A. Adamany,et al.  Impairment of dolichyl saccharide synthesis and dolichol-mediated glycoprotein assembly in the aortic smooth muscle cell in culture by inhibitors of cholesterol biosynthesis. , 1978, The Journal of biological chemistry.

[20]  W. Bensch,et al.  Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylgutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B. , 1978, Biochemical and biophysical research communications.

[21]  B. Ed,et al.  Biochemistry of Polyisoprenoid Biosynthesis , 1976 .

[22]  J. Nordstrom,et al.  Regulation of HMG-CoA reductase. , 1976, Advances in lipid research.

[23]  J. Simpson.  Letter: Weather and myasthenic fatigue. , 1974, Lancet.

[24]  E. Staffeldt,et al.  Brief communication: Enhancement of spontaneous hepatic tumorigenesis in C3H mice by dietary phenobarbital. , 1973, Journal of the National Cancer Institute.

[25]  Kirby Tj.  Cataracts produced by triparanol. (MER-29). , 1967 .

[26]  R. Olson.  Biosynthesis of ubiquinones in animals. , 1966, Vitamins and hormones.