In fl uence of Type 2 Diabetes on Brain Volumes and Changes in Brain Volumes Results from the Women ’ s Health Initiative Magnetic Resonance Imaging Studies

RESEARCH DESIGN AND METHODSdRegional brain volumes and ischemic lesion volumes in 1,366 women, aged 72–89 years, were measured with structural brain magnetic resonance imaging (MRI). Repeat scans were collected an average of 4.7 years later in 698 women. Cross-sectional differences and changes with time between women with and without diabetes were compared. Relationships that cognitive function test scores had with these measures and diabetes were examined.

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