论文信息 - Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin

Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin

ABSTRACT Streptomyces roseochromogenes subsp. oscitans DS 12.976 is the producer of the gyrase-inhibiting aminocoumarin antibiotic clorobiocin. Here, we present a draft genome sequence of this strain, in which we identified the clorobiocin gene cluster as well as an unusually high number (43) of further putative secondary metabolite clusters.

J. Kalinowski | C. Rückert | L. Heide | A. Apel

[1] Kai Blin,et al. antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers , 2013, Nucleic Acids Res..

[2] A. Maxwell,et al. Exploiting bacterial DNA gyrase as a drug target: current state and perspectives , 2011, Applied Microbiology and Biotechnology.

[3] J. Stoye,et al. Sequencing of high G+C microbial genomes using the ultrafast pyrosequencing technology. , 2011, Journal of biotechnology.

[4] Samuel V. Angiuoli,et al. Toward an online repository of Standard Operating Procedures (SOPs) for (meta)genomic annotation. , 2008, Omics : a journal of integrative biology.

[5] L. Heide,et al. Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics. , 2002, Microbiology.