Vaccine and Mycostatin in treatment of cryptococcosis of the respiratory tract.

Three cases of respiratory crytococcosis are described, one diagnosed only after thoracotomy and two after cytology. All were confirmed by cultures, biological and biochemical tests. The patients are alive and well 14 years, 5 years, and 5 years after treatment with crytococcal vaccines and mycostatin. Vaccines proved very effective when given intradermally in small doses and no dangerous reactions were encountered. Cytology of the sputum appears to be a very useful tool in diagnosis of fungal infections of the respiratory tract, especially when supravital staining is used. Difficulties in diagnosis, treatment, and significance of positive sputum findings are discussed.

[1]  A. Beemer,et al.  [Some observations on the incidence, importance and treatment of tinea pedis]. , 1974, Harefuah.

[2]  J. Avigad,et al.  Immunotherapy of superficial dermatomycoses. , 1973, Dermatologica.

[3]  D. Merzbach,et al.  Cryptococcus neoformans Meningitis , 1973 .

[4]  A. Schwartz.  Norman F. Conant, David Tillerson Smith, Roger Denio Baker and Jasper Lamar Callaway, Manual of Clinical Mycology (3. Auflage, Taschenbuchformat). X u. 755 S., 300 Abb., 13 Tab. Philadelphia‐London‐Toronto 1971: W. B. Saunders Comp. £ 5.75 , 1973 .

[5]  [Treatment of a refractory case of pulmonary tuberculosis with PPD]. , 1972, Harefuah.

[6]  A. Beemer,et al.  Cytology for Early Diagnosis of Cryptococcal Tracheo‐bronchitis , 1972, Mykosen.

[7]  L. Friedman,et al.  Mechanisms of Native and Acquired Resistance to Infection with Cryptococcus Neoformans , 1972 .

[8]  A. Beemer,et al.  [Autogenous vaccine therapy in hemoptysis due to pulmonary aspergillosis]. , 1971, Harefuah.

[9]  N. F. Conant.  Manual of clinical mycology , 1971 .

[10]  J. Utz,et al.  MedicaI mycology. Second edition. , 1970 .

[11]  W. Schwartz.  Ferdinand Fegler. Medizinische Mykologie in Praxis und Klinik. XII und 125 S., 82 Abb., 3 Tab. Berlin, Heidelberg. New York 1967: Springer-Verlag. DM 48,– , 1969 .

[12]  A. Beemer,et al.  Vaccine and antimicrobial therapy in pulmonary nocardiosis. , 1969, Scandinavian journal of respiratory diseases.

[13]  J. Bennett,et al.  Variant forms of pulmonary cryptococcosis. , 1968, Annals of internal medicine.

[14]  J. Bates,et al.  The spectrum of pulmonary cryptococcosis. , 1968, Annals of internal medicine.

[15]  N. Mitchison,et al.  The mechanism of immunological paralysis. , 1968, Advances in immunology.

[16]  F. Fegeler.  Medizinische Mykologie in Praxis und Klinik , 1967 .

[17]  G. Campbell.  Primary pulmonary cryptococcosis. , 1966, The American review of respiratory disease.

[18]  I. Abrahams.  Further studies on acquired resistance to murine cryptococcosis: enhancing effect of Bordetella pertussis. , 1966, Journal of immunology.

[19]  P. Pratt,et al.  Pathology of the Lung, 3rd, H. Spencer. Pergamon Press, Oxford, U.K. (1977), 1100, illustrated. US$95.00. (2 volumes). , 1978 .

[20]  A. Beemer,et al.  CRESYL BLUE AND CRESYL BLUE PLUS SUDAN 3 AS STAINS FOR USE IN EXFOLIATIVE AND OTHER CYTOLOGY. , 1964, Bulletin of the World Health Organization.

[21]  D. Thomson,et al.  Oral vaccines and immunization by other unusual routes. , 1948 .