Cationic peptides: a new source of antibiotics.

Antimicrobial cationic peptides are an important component of the innate defenses of all species of life. Different peptides may have antibacterial, antiendotoxic, antibiotic-potentiating or antifungal properties, and so they are being developed for use as a novel class of antimicrobial agents and as the basis for making transgenic disease-resistant plants and animals.

[1]  R. B. Merrifield,et al.  Antibacterial peptides designed as analogs or hybrids of cecropins and melittin. , 2009, International journal of peptide and protein research.

[2]  M. Selsted,et al.  Paneth cell defensins: Endogenous peptide components of intestinal host defense , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  Solution structure of gamma 1-H and gamma 1-P thionins from barley and wheat endosperm determined by 1H-NMR: a structural motif common to toxic arthropod proteins. , 1993 .

[4]  D. Andreu,et al.  Effect of hybrid peptides of cecropin A and melittin in an experimental model of bacterial keratitis. , 1997, Cornea.

[5]  S J Ludtke,et al.  Membrane pores induced by magainin. , 1996, Biochemistry.

[6]  T. Scanlin,et al.  Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha , 1996, Infection and immunity.

[7]  Franky R. G. Terras,et al.  Expression of functional Raphanus sativus antifungal protein in yeast , 1994, FEBS letters.

[8]  Domenico Romeo,et al.  Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domain , 1995, FEBS letters.

[9]  R. Lehrer,et al.  cDNA cloning of three cecropin‐like antimicrobial peptides (Styelins) from the tunicate, Styela clava , 1997, FEBS letters.

[10]  V. Smith,et al.  Purification and characterization of a proline-rich antibacterial peptide, with sequence similarity to bactenecin-7, from the haemocytes of the shore crab, Carcinus maenas. , 1996, European journal of biochemistry.

[11]  E. Valore,et al.  Broad-spectrum antimicrobial activity of human intestinal defensin 5 , 1997, Infection and immunity.

[12]  E. Greenberg,et al.  Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid , 1996, Cell.

[13]  P. Fehlbaum,et al.  Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. , 1994, The Journal of biological chemistry.

[14]  J. Newton,et al.  Enhanced Disease Resistance to Enteric Speticemia in Channel Catfish, Ictalurus punctatus, Administered Lytic Peptide , 1994 .

[15]  R. Lehrer,et al.  Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells , 1996, FEBS letters.

[16]  P. Epple,et al.  Overexpression of an endogenous thionin enhances resistance of Arabidopsis against Fusarium oxysporum. , 1997, The Plant cell.

[17]  R. Hancock,et al.  Recombinant DNA procedures for producing small antimicrobial cationic peptides in bacteria. , 1993, Gene.

[18]  A. Waring,et al.  Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations. , 1996, European journal of biochemistry.

[19]  H. Erdjument-Bromage,et al.  Biodiversity of apidaecin-type peptide antibiotics. Prospects of manipulating the antibacterial spectrum and combating acquired resistance. , 1994, The Journal of biological chemistry.

[20]  C. Roumestand,et al.  Synthesis and solution structure of the antimicrobial peptide protegrin-1. , 1996, European journal of biochemistry.

[21]  J. Johansson,et al.  Secondary structure and membrane interaction of PR-39, a Pro+Arg-rich antibacterial peptide. , 1994, European journal of biochemistry.

[22]  H. Steiner,et al.  Expression of post-translational processing of preprocecropin A using a baculovirus vector. , 1991, European journal of biochemistry.

[23]  B. Bechinger,et al.  Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin , 1997, The Journal of Membrane Biology.

[24]  R. Hancock,et al.  Antiendotoxin activity of cationic peptide antimicrobial agents , 1996, Infection and immunity.

[25]  B. Lemaître,et al.  The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults , 1996, Cell.

[26]  Y. Shai.  Molecular recognition between membrane-spanning polypeptides. , 1995, Trends in biochemical sciences.

[27]  W. Stiekema,et al.  Toxicity of peptides to bacteria present in the vase water of cut roses , 1996 .

[28]  C. Seachord,et al.  Beta-lactam antibiotics potentiate magainin 2 antimicrobial activity in vitro and in vivo , 1991, Antimicrobial Agents and Chemotherapy.

[29]  J. Schröder,et al.  A peptide antibiotic from human skin , 1997, Nature.

[30]  D. Hultmark,et al.  Sequence and specificity of two antibacterial proteins involved in insect immunity , 1981, Nature.

[31]  D. Kohda,et al.  A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide, T22 ([Tyr5,12, Lys7]-polyphemusin II), determined by nuclear magnetic resonance. , 1993, Biochimica et biophysica acta.

[32]  E. Levashina,et al.  Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties. , 1995, European journal of biochemistry.

[33]  Franky R. G. Terras,et al.  Plant Defensins: Novel Antimicrobial Peptides as Components of the Host Defense System , 1995, Plant physiology.

[34]  S. Projan,et al.  Evaluation of a nisin-based germicidal formulation on teat skin of live cows. , 1992, Journal of dairy science.

[35]  T. Ganz,et al.  Endogenous Vertebrate Antibiotics , 1996 .

[36]  R. Leah,et al.  Enhanced quantitative resistance against fungal disease by combinatorial expression of different barley antifungal proteins in transgenic tobacco. , 1995, The Plant journal : for cell and molecular biology.

[37]  J. Fiddes,et al.  Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity , 1997, Antimicrobial agents and chemotherapy.

[38]  A. Molina,et al.  Expression of the alpha-thionin gene from barley in tobacco confers enhanced resistance to bacterial pathogens. , 1993, The Plant journal : for cell and molecular biology.

[39]  James M. Wilson,et al.  Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis , 1997, Cell.

[40]  J. Jaynes,et al.  Expression of a Cecropin B lytic peptide analog in transgenic tobacco confers enhanced resistance to bacterial wilt caused by Pseudomonas solanacearum , 1993 .

[41]  M. Raida,et al.  hBD‐1: a novel β‐defensin from human plasma , 1995 .