Why Pleiotropic Interventions are Needed for Alzheimer's Disease
暂无分享,去创建一个
[1] J. Trojanowski,et al. Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors , 2010, Experimental Neurology.
[2] G. Cole,et al. DHA may prevent age-related dementia. , 2010, The Journal of nutrition.
[3] Winnie S. Liang,et al. Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology , 2010, Neurobiology of Aging.
[4] C. Jack,et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade , 2010, The Lancet Neurology.
[5] G. Maru,et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. , 2010, Journal of agricultural and food chemistry.
[6] P. Scheltens,et al. Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial , 2010, Alzheimer's & Dementia.
[7] M. O’Banion,et al. Sustained expression of interleukin-1β in mouse hippocampus impairs spatial memory , 2009, Neuroscience.
[8] Robert C Green,et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. , 2009, JAMA.
[9] Bedda L. Rosario,et al. Basal Cerebral Metabolism May Modulate the Cognitive Effects of Aβ in Mild Cognitive Impairment: An Example of Brain Reserve , 2009, The Journal of Neuroscience.
[10] Seiji Nishino,et al. Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle , 2009, Science.
[11] G. Johnson,et al. Involvement of oxidative pathways in cytokine-induced secretory phospholipase A2-IIA in astrocytes , 2009, Neurochemistry International.
[12] L. Mosconi,et al. Differences in hippocampal metabolism between amnestic and non-amnestic MCI subjects: automated FDG-PET image analysis. , 2009, The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of....
[13] C. Laiño. In Follow‐up Analysis of Clinical Trial, NSAIDs Seem to Preserve Cognitive Function in Patients with Healthy Brains , 2009 .
[14] P. Davies,et al. Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology , 2009, The Journal of Neuroscience.
[15] R. Hamilton,et al. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease , 2009, Proceedings of the National Academy of Sciences.
[16] G. Cole,et al. Omega-3 fatty acids and dementia. , 2009, Prostaglandins, leukotrienes, and essential fatty acids.
[17] H. Vinters,et al. β-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin , 2009, The Journal of Neuroscience.
[18] G. Casadesus,et al. Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease , 2009, Free radical research.
[19] Libin Cui,et al. Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid , 2009, Proceedings of the National Academy of Sciences.
[20] E. Teng,et al. Donepezil delays progression to AD in MCI subjects with depressive symptoms , 2009, Neurology.
[21] S. Pimplikar,et al. Reassessing the amyloid cascade hypothesis of Alzheimer's disease. , 2009, The international journal of biochemistry & cell biology.
[22] O. Shido,et al. Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix–loop–helix transcription factors and cell cycle in neural stem cells , 2009, Neuroscience.
[23] P. Pasqualetti,et al. A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer’s disease , 2009, Aging clinical and experimental research.
[24] T. Kokjohn,et al. Antibody responses, amyloid-beta peptide remnants and clinical effects of AN-1792 immunization in patients with AD in an interrupted trial. , 2009, CNS & neurological disorders drug targets.
[25] Xue-jun Li,et al. Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: possible involvement of the ERK1/2 pathway. , 2009, Basic & clinical pharmacology & toxicology.
[26] Suzanne Craft,et al. The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged. , 2009, Archives of neurology.
[27] P. Dederen,et al. DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice , 2009, Neurobiology of Disease.
[28] E. Mandelkow,et al. Development of tau aggregation inhibitors for Alzheimer's disease. , 2009, Angewandte Chemie.
[29] G. Cole,et al. GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals , 2009, Neurobiology of Disease.
[30] J. W. Rudy,et al. Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection , 2009, Brain, Behavior, and Immunity.
[31] I. Grundke‐Iqbal,et al. Mechanisms of tau-induced neurodegeneration , 2009, Acta Neuropathologica.
[32] A. Palmeri,et al. Picomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus , 2008, The Journal of Neuroscience.
[33] S. DeKosky,et al. Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease , 2008, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[34] B. Hemmer,et al. Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab. , 2008, Archives of neurology.
[35] L. Mucke,et al. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease , 2008, Nature Neuroscience.
[36] Edward E Knaus,et al. Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. , 2008, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
[37] T. Wisniewski,et al. Amyloid-β immunisation for Alzheimer's disease , 2008, The Lancet Neurology.
[38] Osman A. B. S. M. Gani,et al. Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha. , 2008, Journal of molecular graphics & modelling.
[39] F. Gomez-Pinilla,et al. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition , 2008, Neuroscience.
[40] Shih-Yi Huang,et al. The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study , 2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[41] J. Morris,et al. Will anti-amyloid therapies work for Alzheimer's disease? , 2008, The Lancet.
[42] Seth Love,et al. Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial , 2008, The Lancet.
[43] Takashi Morihara,et al. Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease , 2008, Journal of Pharmacology and Experimental Therapeutics.
[44] R. Green,et al. Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. , 2008, Archives of neurology.
[45] Á. Simonyi,et al. Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons , 2008, Journal of neurochemistry.
[46] E. Faustman,et al. Fish intake guidelines: incorporating n-3 fatty acid intake and contaminant exposure in the Korean and Japanese communities. , 2008, The American journal of clinical nutrition.
[47] S. Hendrix,et al. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial , 2008, The Lancet Neurology.
[48] M. Mattson,et al. Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus* , 2008, Journal of Biological Chemistry.
[49] Donald R. Miller,et al. Protective effects of NSAIDs on the development of Alzheimer disease , 2008, Neurology.
[50] S. Wassall,et al. Docosahexaenoic acid domains: the ultimate non-raft membrane domain. , 2008, Chemistry and physics of lipids.
[51] S. Ogston,et al. Cod liver oil (n-3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis. , 2008, Rheumatology.
[52] R. Veerhuis,et al. Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology. , 2008, Current pharmaceutical design.
[53] B. Jenkins,et al. Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice , 2008, Brain Research.
[54] M. Hill,et al. A Two-Year Study with Fibrillar β-Amyloid (Aβ) Immunization in Aged Canines: Effects on Cognitive Function and Brain Aβ , 2008, The Journal of Neuroscience.
[55] T. Wisniewski,et al. 5‐Lipoxygenase gene disruption reduces amyloid‐β pathology in a mouse model of Alzheimer's disease , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[56] V. Mok,et al. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. , 2008, Journal of clinical psychopharmacology.
[57] E. Mandelkow,et al. Curcumin‐Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease? , 2008, ChemMedChem.
[58] B. Teter,et al. Omega-3 Fatty Acid Docosahexaenoic Acid Increases SorLA/LR11, a Sorting Protein with Reduced Expression in Sporadic Alzheimer's Disease (AD): Relevance to AD Prevention , 2007, The Journal of Neuroscience.
[59] A. Takashima,et al. Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild‐type human tau , 2007, The EMBO journal.
[60] A. Delgado-Escueta,et al. Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo , 2007, Proceedings of the National Academy of Sciences.
[61] Fei Liu,et al. Down‐regulation of cAMP‐dependent protein kinase by over‐activated calpain in Alzheimer disease brain , 2007, Journal of neurochemistry.
[62] F. Calderon,et al. Role of RXR in neurite outgrowth induced by docosahexaenoic acid. , 2007, Prostaglandins, leukotrienes, and essential fatty acids.
[63] F. Pifferi,et al. n-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrier. , 2007, Prostaglandins, leukotrienes, and essential fatty acids.
[64] H. Tanila,et al. Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD) , 2007, Neurobiology of Disease.
[65] M. Lynch,et al. Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: a lipidomic analysis. , 2007, Prostaglandins, leukotrienes, and essential fatty acids.
[66] J. Trojanowski,et al. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders , 2007, Nature Reviews Neuroscience.
[67] B. Hyman,et al. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model , 2007, Journal of neurochemistry.
[68] J. Lucas,et al. Neuronal apoptosis and reversible motor deficit in dominant‐negative GSK‐3 conditional transgenic mice , 2007, The EMBO journal.
[69] M. O’Banion,et al. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. , 2007, The Journal of clinical investigation.
[70] W. M. van der Flier,et al. ASSOCIATION BETWEEN VITAMIN B6 AND WHITE MATTER HYPERINTENSITIES IN PATIENTS WITH ALZHEIMER'S DISEASE NOT MEDIATED BY HOMOCYSTEINE METABOLISM , 2007, Journal of the American Geriatrics Society.
[71] Patrick L. McGeer,et al. NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies , 2007, Neurobiology of Aging.
[72] Frank M LaFerla,et al. Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels , 2007, The Journal of Neuroscience.
[73] S. Innis,et al. Dietary (n-3) fatty acids and brain development. , 2007, The Journal of nutrition.
[74] G. Collingridge,et al. LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β , 2007, Neuron.
[75] B. Rodrigues,et al. Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism. , 2007, American journal of physiology. Endocrinology and metabolism.
[76] Rhoda Au,et al. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. , 2006, Archives of neurology.
[77] Michio Hashimoto,et al. DOCOSAHEXAENOIC ACID‐INDUCED PROTECTIVE EFFECT AGAINST IMPAIRED LEARNING IN AMYLOID β‐INFUSED RATS IS ASSOCIATED WITH INCREASED SYNAPTOSOMAL MEMBRANE FLUIDITY , 2006, Clinical and experimental pharmacology & physiology.
[78] G. Cole,et al. Commentary on “Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery.” Pleiotropic approaches to Alzheimer’s and other diseases of aging , 2006, Alzheimer's & Dementia.
[79] G. Caughey,et al. Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritis. , 2006, The Journal of rheumatology.
[80] Lars-Olof Wahlund,et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. , 2006, Archives of neurology.
[81] J. Trojanowski,et al. Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery , 2006, Alzheimer's & Dementia.
[82] J. Hey-Hadavi. Commentary on “Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery.” Atorvastatin’s effect in Alzheimer’s dementia (LEADe) study , 2006, Alzheimer's & Dementia.
[83] Eun Kyoung Ryu,et al. Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. , 2006, Journal of medicinal chemistry.
[84] H. Tanila,et al. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice , 2006, Neurobiology of Disease.
[85] G. Cole,et al. Docosahexaenoic Acid Protects from Amyloid and Dendritic Pathology in an Alzheimer's Disease Mouse Model , 2006, Nutrition and health.
[86] K. Ashe. S5-03-03 A specific amyloid-β assembly in the brain impairs memory , 2006, Alzheimer's & Dementia.
[87] S. Kang,et al. Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells. , 2006, Stem cells and development.
[88] R. Koch,et al. Omega-3 fatty acids improve the diagnosis-related clinical outcome* , 2006, Critical care medicine.
[89] M. Gallagher,et al. A specific amyloid-β protein assembly in the brain impairs memory , 2006, Nature.
[90] R. Mrak,et al. Potential inflammatory biomarkers in Alzheimer's disease. , 2006, Journal of Alzheimer's disease : JAD.
[91] E. Mandelkow,et al. Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy , 2006, Journal of Biological Chemistry.
[92] T. Klockgether,et al. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[93] K. Ashe,et al. Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L) , 2005, The Journal of Neuroscience.
[94] T. Montine,et al. Deletion of the Prostaglandin E2 EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease , 2005, The Journal of Neuroscience.
[95] Charles N Serhan,et al. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. , 2005, The Journal of clinical investigation.
[96] Zhiming Wen,et al. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[97] Takashi Morihara,et al. Dietary n‐3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease , 2005, The European journal of neuroscience.
[98] P. Scheltens,et al. LOW VITAMIN B6 LEVELS ARE ASSOCIATED WITH WHITE MATTER LESIONS IN ALZHEIMER'S DISEASE , 2005, Journal of the American Geriatrics Society.
[99] P. Hof,et al. Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms , 2005, The Journal of Neuroscience.
[100] B. Teter,et al. Ibuprofen Suppresses Interleukin-1β Induction of Pro-Amyloidogenic α1-Antichymotrypsin to Ameliorate β-Amyloid (Aβ) Pathology in Alzheimer's Models , 2005, Neuropsychopharmacology.
[101] Thomas Klockgether,et al. Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice , 2005 .
[102] R. Ravid,et al. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology , 2005, Journal of neurochemistry.
[103] Takashi Morihara,et al. A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model , 2005, The Journal of Neuroscience.
[104] R. Mrak,et al. Glia and their cytokines in progression of neurodegeneration , 2005, Neurobiology of Aging.
[105] Fusheng Yang,et al. Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo* , 2005, Journal of Biological Chemistry.
[106] Chi Li,et al. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[107] D. Perani,et al. MCI conversion to dementia and the APOE genotype , 2004, Neurology.
[108] B. Teter,et al. Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention , 2004, The Journal of Neuroscience.
[109] G. Cole,et al. NSAID and Antioxidant Prevention of Alzheimer's Disease: Lessons from In Vitro and Animal Models , 2004, Annals of the New York Academy of Sciences.
[110] J. Trojanowski,et al. Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis , 2004, Journal of Neuroinflammation.
[111] A. Stoll,et al. Omega-3 Fatty Acid Treatment and T2 Whole Brain Relaxation Times in Bipolar Disorder , 2004 .
[112] Takashi Morihara,et al. Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model , 2004, Neuron.
[113] S. Sang,et al. Modulation of arachidonic acid metabolism by curcumin and related β-diketone derivatives: effects on cytosolic phospholipase A2, cyclooxygenases and 5-lipoxygenase , 2004 .
[114] Chung Y. Hsu,et al. Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat brain , 2004, Journal of neurochemistry.
[115] S. Goodman,et al. Nonsteroidal Anti-Inflammatory Drugs for the Prevention of Alzheimer’s Disease: A Systematic Review , 2004, Neuroepidemiology.
[116] Patrick L. McGeer,et al. Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease , 2004, Experimental Neurology.
[117] Hyoung-Gon Lee,et al. Challenging the Amyloid Cascade Hypothesis: Senile Plaques and Amyloid‐β as Protective Adaptations to Alzheimer Disease , 2004, Annals of the New York Academy of Sciences.
[118] B. Zipser,et al. Accumulation of high-molecular-weight amylose in Alzheimer's disease brains. , 2004, Glycobiology.
[119] A. Dennison,et al. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration , 2004, British Journal of Cancer.
[120] T. Montine,et al. Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. , 2004, Chemistry and physics of lipids.
[121] R. Jope,et al. The glamour and gloom of glycogen synthase kinase-3. , 2004, Trends in biochemical sciences.
[122] J. Trojanowski,et al. Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[123] Melina R. Uncapher,et al. Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia , 2003, Neurology.
[124] Thomas Klockgether,et al. Nonsteroidal Anti-Inflammatory Drugs and Peroxisome Proliferator-Activated Receptor-γ Agonists Modulate Immunostimulated Processing of Amyloid Precursor Protein through Regulation of β-Secretase , 2003, The Journal of Neuroscience.
[125] M. Citron,et al. Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease , 2003, The Journal of Neuroscience.
[126] G. J. Raymond,et al. Inhibition of Protease-Resistant Prion Protein Accumulation In Vitro by Curcumin , 2003, Journal of Virology.
[127] S. Barger,et al. Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway , 2003, The Journal of Neuroscience.
[128] J. Cummings,et al. A Rationale for Curcuminoids for the Prevention or Treatment of Alzheimers Disease , 2003 .
[129] G. Barceló-Coblijn,et al. Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[130] Takashi Morihara,et al. Selective inhibition of Aβ42 production by NSAID R‐enantiomers , 2002 .
[131] N. Nakamichi,et al. Blockade by ferrous iron of Ca2+ influx through N‐methyl‐d‐aspartate receptor channels in immature cultured rat cortical neurons , 2002, Journal of neurochemistry.
[132] John D Lambris,et al. Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[133] D. Bennett,et al. Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study , 2022 .
[134] W. K. Cullen,et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.
[135] T. Klockgether,et al. Noradrenergic Depletion Potentiates β-Amyloid-Induced Cortical Inflammation: Implications for Alzheimer's Disease , 2002, The Journal of Neuroscience.
[136] G. Morris. Wolff's Headache and Other Head Pain , 2002 .
[137] A. Brand,et al. Docosahexaenoic Acid Abundance in the Brain: A biodevice to Combat Oxidative Stress , 2002, Nutritional neuroscience.
[138] Xiongwei Zhu,et al. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis , 2001, Mechanisms of Ageing and Development.
[139] J. Overmier,et al. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice , 2001, Neurobiology of Aging.
[140] G. M. Cole,et al. Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology , 2001, Neurobiology of Aging.
[141] G. Cole,et al. The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse , 2001, The Journal of Neuroscience.
[142] D. Dickson,et al. Analysis of tauopathies with transgenic mice. , 2001, Trends in molecular medicine.
[143] Hee-Yong Kim,et al. Mechanisms of action of docosahexaenoic acid in the nervous system , 2001, Lipids.
[144] D. C. Mitchell,et al. The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways , 2001, Journal of Molecular Neuroscience.
[145] G. Cole,et al. Church baptizes Joseph and Perry. Eccentric views absolved , 2001, Neurobiology of Aging.
[146] T. Perlmann,et al. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. , 2000, Science.
[147] K. Ashe,et al. Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease , 2000, The Journal of Neuroscience.
[148] C. Plata-salamán,et al. Inflammation and Alzheimer’s disease , 2000, Neurobiology of Aging.
[149] S. Nishiyama,et al. Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeys , 2000, Brain Research.
[150] G. Wenk,et al. Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats , 2000, Brain Research.
[151] L. Parnetti,et al. Cerebrospinal fluid pyruvate levels in Alzheimer’s disease and vascular dementia , 2000, Neurology.
[152] A. Yang,et al. Complement Component C1q Modulates the Phagocytosis of Aβ by Microglia , 2000, Experimental Neurology.
[153] J L Andersson,et al. Brain regions associated with episodic retrieval in normal aging and Alzheimer’s disease , 1999, Neurology.
[154] J. Morris,et al. Tangles and plaques in nondemented aging and “preclinical” Alzheimer's disease , 1999, Annals of neurology.
[155] M. Hossain,et al. Antioxidative Effects of Docosahexaenoic Acid in the Cerebrum Versus Cerebellum and Brainstem of Aged Hypercholesterolemic Rats , 1999, Journal of neurochemistry.
[156] B. Halliwell,et al. F4 ‐ Isoprostanes as Specific Marker of Docosahexaenoic Acid Peroxidation in Alzheimer's Disease , 1999, Journal of neurochemistry.
[157] T. Tan,et al. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin , 1998, Oncogene.
[158] M. Lynch,et al. Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation , 1998, The Journal of Neuroscience.
[159] T. Montine,et al. 4‐Hydroxy‐2‐Nonenal Pyrrole Adducts in Human Neurodegenerative Disease , 1997, Journal of neuropathology and experimental neurology.
[160] M. Mattson,et al. Secreted form of β‐amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices , 1997, Neuroreport.
[161] J. Rogers,et al. Aggregation State‐Dependent Activation of the Classical Complement Pathway by the Amyloid β Peptide , 1997, Journal of neurochemistry.
[162] L. Lue,et al. Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease , 1997, Neurobiology of Aging.
[163] P Woodbury,et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. , 1997, The New England journal of medicine.
[164] E. Masliah,et al. Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation. , 1996, Molecular and chemical neuropathology.
[165] M. Beal,et al. Oxidative damage in Alzheimer's , 1996, Nature.
[166] Thomas E. Nichols,et al. Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer's disease , 1996, Neurology.
[167] J. Price,et al. Cerebral amyloid deposition and diffuse plaques in ``normal'' aging , 1996, Neurology.
[168] Thomas E. Nichols,et al. Alterations in Functional Neuroanatomical Connectivity in Alzheimer's Disease , 1996, Annals of the New York Academy of Sciences.
[169] L. Parnetti,et al. INCREASED CSF PYRUVATE LEVELS AS A MARKER OF IMPAIRED ENERGY METABOLISM IN ALZHEIMER'S DISEASE , 1995, Journal of the American Geriatrics Society.
[170] C. Rao,et al. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. , 1995, Cancer research.
[171] C. Behl,et al. Hydrogen peroxide mediates amyloid β protein toxicity , 1994, Cell.
[172] G. Reynolds,et al. Monoamine neurotransmitters and their metabolites in brain regions in alzheimer's disease: A postmortem study , 1992, Cellular and Molecular Neurobiology.
[173] G. Cole,et al. Vitamin E protects nerve cells from amyloid βprotein toxicity , 1992 .
[174] G. Cole,et al. Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid. , 1992, The American journal of pathology.
[175] J. Hardy,et al. Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.
[176] D. Salmon,et al. Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment , 1991, Annals of neurology.
[177] A. Conney,et al. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. , 1991, Cancer research.
[178] J. Moossy,et al. Brain Regional Analysis of NADH‐Cytochrome C Reductase Activity in Alzheimer's Disease , 1990, Journal of neuropathology and experimental neurology.
[179] R. Katzman.,et al. Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques , 1988, Annals of neurology.
[180] H. Kimura,et al. [Reduced nicotinamide adenine dinucleotide phosphate diaphorase histochemistry in neocortex and hippocampus in patients with Alzheimer type dementia and aged controls]. , 1987, Rinshō shinkeigaku Clinical neurology.
[181] R. Sapolsky. Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[182] T. Crow,et al. Loss of endoplasmic reticulum-associated enzymes in affected brain regions in Huntington's disease and Alzheimer-type dementia , 1985, Journal of the Neurological Sciences.
[183] L. Butcher,et al. Alzheimer dementia and reduced nicotinamide adenine dinucleotide (NADH)-diaphorase activity in senile plaques and the basal forebrain , 1985, Neuroscience Letters.
[184] S. Angaji,et al. Neuroprotective Effects Of Curcumin , 2011 .
[185] P. Mcgeer,et al. Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy. , 2010, Journal of Alzheimer's disease : JAD.
[186] R. Castellani,et al. Alzheimer disease. , 2010, Disease-a-month : DM.
[187] J. Hardy,et al. The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .
[188] P. Aisen. The inflammatory hypothesis of Alzheimer disease: dead or alive? , 2008, Alzheimer disease and associated disorders.
[189] B. Aggarwal,et al. Curcumin: the Indian solid gold. , 2007, Advances in experimental medicine and biology.
[190] G. Wolf. Estimation of the human daily requirement of vitamin E by turnover kinetics of labeled RRR-alpha-tocopherol. , 2007, Nutrition reviews.
[191] G. Cole,et al. Phagocytosis and Deposition of Vascular -amyloid in Rat Brains Injected with Alzheimer -amyloid , 2007 .
[192] S. Rapoport,et al. n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism , 2007, Molecular Psychiatry.
[193] Akihiko Takashima,et al. GSK-3 is essential in the pathogenesis of Alzheimer's disease. , 2006, Journal of Alzheimer's disease : JAD.
[194] M. A. Levine,et al. Determination of Mercury in an Assortment of Dietary Supplements Using an Inexpensive Combustion Atomic Absorption Spectrometry Technique , 2005, Journal of automated methods & management in chemistry.
[195] Michael T Heneka,et al. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. , 2005, Brain : a journal of neurology.
[196] T. Klockgether,et al. Nonsteroidal anti-inflammatory drugs repress (cid:1) -secretase gene promoter activity by the activation of PPAR (cid:2) , 2005 .
[197] L. Baum,et al. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. , 2004, Journal of Alzheimer's disease : JAD.
[198] T. Montine,et al. Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease. , 2004, Journal of Alzheimer's disease : JAD.
[199] H. Braak,et al. Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.
[200] Deborah Gustafson,et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. , 2004, Archives of neurology.
[201] A. Stoll,et al. Omega-3 fatty acid treatment and T(2) whole brain relaxation times in bipolar disorder. , 2004, The American journal of psychiatry.
[202] D. Mann,et al. Glycogen accumulations in the cerebral cortex in Alzheimer's disease , 2004, Acta Neuropathologica.
[203] T. Montine,et al. Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. , 2001, The American journal of pathology.
[204] T. Arendt,et al. Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease , 1999, Journal of Neural Transmission.
[205] B. Hyman,et al. Microglial response to amyloid plaques in APPsw transgenic mice. , 1998, The American journal of pathology.
[206] G. Omenn,et al. Strategy and planning for chemopreventive drug development: Clinical development plans II , 1996, Journal of cellular biochemistry. Supplement.
[207] Y. Enokido,et al. [Neuronal apoptosis]. , 1995, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.