J Ournal of Orthopaedic Surgery and Research Open Access Fibrin and Poly(lactic-co-glycolic Acid) Hybrid Scaffold Promotes Early Chondrogenesis of Articular Chondrocytes: an in Vitro Study

Background: Synthetic-and naturally derived-biodegradable polymers have been widely used to construct scaffolds for cartilage tissue engineering. Poly(lactic-co-glycolic acid) (PLGA) are bioresorbable and biocompatible, rendering them as a promising tool for clinical application. To minimize cells lost during the seeding procedure, we used the natural polymer fibrin to immobilize cells and to provide homogenous cells distribution in PLGA scaffolds. We evaluated in vitro chondrogenesis of rabbit articular chondrocytes in PLGA scaffolds using fibrin as cell transplantation matrix.

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